2D1F
Structure of Mycobacterium tuberculosis threonine synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004795 | molecular_function | threonine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
| B | 0004795 | molecular_function | threonine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 500 |
| Chain | Residue |
| A | SER67 |
| A | ASN200 |
| A | GLU296 |
| A | THR326 |
| A | HOH503 |
| A | HOH507 |
| A | HOH524 |
| A | PHE68 |
| A | LYS69 |
| A | ASN95 |
| A | VAL195 |
| A | GLY196 |
| A | ASN197 |
| A | ALA198 |
| A | GLY199 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP B 500 |
| Chain | Residue |
| B | SER67 |
| B | PHE68 |
| B | LYS69 |
| B | ASN95 |
| B | VAL195 |
| B | GLY196 |
| B | ASN197 |
| B | ALA198 |
| B | GLY199 |
| B | ASN200 |
| B | GLU296 |
| B | ALA298 |
| B | THR326 |
| B | GLY327 |
| B | HOH502 |
| B | HOH503 |
| B | HOH507 |
Functional Information from PROSITE/UniProt
| site_id | PS00165 |
| Number of Residues | 14 |
| Details | DEHYDRATASE_SER_THR Serine/threonine dehydratases pyridoxal-phosphate attachment site. Eglnp.TGSFKDRGM |
| Chain | Residue | Details |
| A | GLU60-MET73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18621388 |
| Chain | Residue | Details |
| A | ASN95 | |
| B | GLY196 | |
| B | THR326 | |
| A | GLY196 | |
| A | THR326 | |
| B | ASN95 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609 |
| Chain | Residue | Details |
| A | THR2 | |
| B | THR2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:18621388 |
| Chain | Residue | Details |
| A | LYS69 | |
| B | LYS69 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20066036 |
| Chain | Residue | Details |
| A | LYS151 | |
| B | LYS151 |
