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2D0U

Crystal structure of cyanide bound form of human indoleamine 2,3-dioxygenase

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002666biological_processpositive regulation of T cell tolerance induction
A0002678biological_processpositive regulation of chronic inflammatory response
A0002830biological_processpositive regulation of type 2 immune response
A0004833molecular_functionL-tryptophan 2,3-dioxygenase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006569biological_processL-tryptophan catabolic process
A0006954biological_processinflammatory response
A0007565biological_processfemale pregnancy
A0009055molecular_functionelectron transfer activity
A0016491molecular_functionoxidoreductase activity
A0019441biological_processL-tryptophan catabolic process to kynurenine
A0019805biological_processquinolinate biosynthetic process
A0020037molecular_functionheme binding
A0030485cellular_componentsmooth muscle contractile fiber
A0032421cellular_componentstereocilium bundle
A0032496biological_processresponse to lipopolysaccharide
A0032693biological_processnegative regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0033555biological_processmulticellular organismal response to stress
A0033754molecular_functionindoleamine 2,3-dioxygenase activity
A0034276biological_processkynurenic acid biosynthetic process
A0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
A0036269biological_processswimming behavior
A0042098biological_processT cell proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0043065biological_processpositive regulation of apoptotic process
A0046006biological_processregulation of activated T cell proliferation
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
B0002376biological_processimmune system process
B0002666biological_processpositive regulation of T cell tolerance induction
B0002678biological_processpositive regulation of chronic inflammatory response
B0002830biological_processpositive regulation of type 2 immune response
B0004833molecular_functionL-tryptophan 2,3-dioxygenase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006569biological_processL-tryptophan catabolic process
B0006954biological_processinflammatory response
B0007565biological_processfemale pregnancy
B0009055molecular_functionelectron transfer activity
B0016491molecular_functionoxidoreductase activity
B0019441biological_processL-tryptophan catabolic process to kynurenine
B0019805biological_processquinolinate biosynthetic process
B0020037molecular_functionheme binding
B0030485cellular_componentsmooth muscle contractile fiber
B0032421cellular_componentstereocilium bundle
B0032496biological_processresponse to lipopolysaccharide
B0032693biological_processnegative regulation of interleukin-10 production
B0032735biological_processpositive regulation of interleukin-12 production
B0033555biological_processmulticellular organismal response to stress
B0033754molecular_functionindoleamine 2,3-dioxygenase activity
B0034276biological_processkynurenic acid biosynthetic process
B0034354biological_process'de novo' NAD+ biosynthetic process from L-tryptophan
B0036269biological_processswimming behavior
B0042098biological_processT cell proliferation
B0042130biological_processnegative regulation of T cell proliferation
B0043065biological_processpositive regulation of apoptotic process
B0046006biological_processregulation of activated T cell proliferation
B0046872molecular_functionmetal ion binding
B0051213molecular_functiondioxygenase activity
B0070233biological_processnegative regulation of T cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CYN A 405
ChainResidue
ASER263
AALA264
AHEM404
ANHE406

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CYN B 1405
ChainResidue
BSER263
BALA264
BHEM404

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE HEM A 404
ChainResidue
AVAL170
APHE214
APHE226
ASER263
AALA264
AGLY265
AARG343
AHIS346
AILE349
ALEU384
AVAL391
ACYN405
ANHE406
ANHE407
APHE163
ASER167

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE NHE A 406
ChainResidue
AGLY236
AGLY261
AGLY262
ASER263
AHEM404
ACYN405
ANHE407

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NHE A 407
ChainResidue
AARG231
AHIS287
APHE291
ALEU384
AHEM404
ANHE406

site_idAC6
Number of Residues20
DetailsBINDING SITE FOR RESIDUE HEM B 404
ChainResidue
BPHE163
BSER167
BVAL170
BPHE214
BPHE226
BSER263
BALA264
BGLY265
BPHE270
BPHE291
BARG343
BHIS346
BILE349
BTYR353
BILE354
BLEU384
BVAL391
BCYN1405
BNHE1406
BNHE1407

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NHE B 1406
ChainResidue
BPHE226
BSER235
BGLY236
BGLY261
BGLY262
BSER263
BHEM404
BNHE1407

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NHE B 1407
ChainResidue
BARG231
BHIS287
BLEU384
BHEM404
BNHE1406

Functional Information from PROSITE/UniProt
site_idPS00876
Number of Residues11
DetailsIDO_1 Indoleamine 2,3-dioxygenase signature 1. GGSAGQSSvfQ
ChainResidueDetails
AGLY261-GLN271

site_idPS00877
Number of Residues14
DetailsIDO_2 Indoleamine 2,3-dioxygenase signature 2. FLQDMrrYMppaHR
ChainResidueDetails
APHE291-ARG304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBinding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"16477023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25313323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PK6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

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