2D0E
Substrate assited in Oxygen Activation in Cytochrome P450 158A2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0020037 | molecular_function | heme binding |
| A | 0042440 | biological_process | pigment metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE HEM A 408 |
| Chain | Residue |
| A | ARG71 |
| A | HIS287 |
| A | ARG295 |
| A | TYR318 |
| A | SER345 |
| A | PHE346 |
| A | HIS351 |
| A | CYS353 |
| A | PRO354 |
| A | ALA359 |
| A | NQ409 |
| A | VAL93 |
| A | HOH526 |
| A | HOH532 |
| A | GLY94 |
| A | HIS101 |
| A | ARG105 |
| A | PHE112 |
| A | LEU239 |
| A | GLY242 |
| A | GLY243 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NQ A 409 |
| Chain | Residue |
| A | HIS287 |
| A | ARG288 |
| A | ILE394 |
| A | HEM408 |
| A | NQ410 |
| A | HOH604 |
| A | HOH611 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NQ A 410 |
| Chain | Residue |
| A | ILE87 |
| A | PRO88 |
| A | ARG288 |
| A | ILE394 |
| A | NQ409 |
| A | HOH637 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGPHYCPG |
| Chain | Residue | Details |
| A | PHE346-GLY355 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15659395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16239228","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D09","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"15659395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16239228","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22203090","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S1F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in determining product regiospecificity","evidences":[{"source":"PubMed","id":"22203090","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
