2D07
Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000700 | molecular_function | mismatch base pair DNA N-glycosylase activity |
| A | 0006285 | biological_process | base-excision repair, AP site formation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0016605 | cellular_component | PML body |
| B | 0016925 | biological_process | protein sumoylation |
| B | 0019789 | molecular_function | SUMO transferase activity |
| B | 0031386 | molecular_function | protein tag activity |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| B | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| B | 0098793 | cellular_component | presynapse |
| B | 0098794 | cellular_component | postsynapse |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0098982 | cellular_component | GABA-ergic synapse |
| B | 0099523 | cellular_component | presynaptic cytosol |
| B | 0099524 | cellular_component | postsynaptic cytosol |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| B | LYS11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CROSSLNK: Peptide (Met-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23560854 |
| Chain | Residue | Details |
| B | MET1 | |
| A | LYS330 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| B | GLY93 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:18408734 |
| Chain | Residue | Details |
| B | LYS11 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS21 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1mug |
| Chain | Residue | Details |
| A | ASN140 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 834 |
| Chain | Residue | Details |
| A | ASN140 | electrostatic interaction |
| A | HIS151 | proton acceptor, proton donor |
