2CYX

Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0032446	biological_process	protein modification by small protein conjugation
A	0035458	biological_process	cellular response to interferon-beta
A	0036503	biological_process	ERAD pathway
A	0042802	molecular_function	identical protein binding
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	1904153	biological_process	negative regulation of retrograde protein transport, ER to cytosol
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0032446	biological_process	protein modification by small protein conjugation
B	0035458	biological_process	cellular response to interferon-beta
B	0036503	biological_process	ERAD pathway
B	0042802	molecular_function	identical protein binding
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	1904153	biological_process	negative regulation of retrograde protein transport, ER to cytosol
C	0000166	molecular_function	nucleotide binding
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0032446	biological_process	protein modification by small protein conjugation
C	0035458	biological_process	cellular response to interferon-beta
C	0036503	biological_process	ERAD pathway
C	0042802	molecular_function	identical protein binding
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070936	biological_process	protein K48-linked ubiquitination
C	1904153	biological_process	negative regulation of retrograde protein transport, ER to cytosol

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNIypd.GrVCIsiL

Chain	Residue	Details
A	PHE78-LEU93

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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