2CXU
Crystal structure of mouse AMF / M6P complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001701 | biological_process | in utero embryonic development |
A | 0001707 | biological_process | mesoderm formation |
A | 0002639 | biological_process | positive regulation of immunoglobulin production |
A | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
A | 0005125 | molecular_function | cytokine activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
A | 0006094 | biological_process | gluconeogenesis |
A | 0006096 | biological_process | glycolytic process |
A | 0007165 | biological_process | signal transduction |
A | 0007611 | biological_process | learning or memory |
A | 0008083 | molecular_function | growth factor activity |
A | 0010595 | biological_process | positive regulation of endothelial cell migration |
A | 0016853 | molecular_function | isomerase activity |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0032355 | biological_process | response to estradiol |
A | 0032570 | biological_process | response to progesterone |
A | 0033574 | biological_process | response to testosterone |
A | 0034101 | biological_process | erythrocyte homeostasis |
A | 0035902 | biological_process | response to immobilization stress |
A | 0035994 | biological_process | response to muscle stretch |
A | 0042593 | biological_process | glucose homeostasis |
A | 0043209 | cellular_component | myelin sheath |
A | 0043524 | biological_process | negative regulation of neuron apoptotic process |
A | 0046686 | biological_process | response to cadmium ion |
A | 0048029 | molecular_function | monosaccharide binding |
A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
A | 0060170 | cellular_component | ciliary membrane |
A | 0061620 | biological_process | glycolytic process through glucose-6-phosphate |
A | 0061621 | biological_process | canonical glycolysis |
A | 0097367 | molecular_function | carbohydrate derivative binding |
A | 0141199 | biological_process | GDP-mannose biosynthetic process from glucose |
A | 1901135 | biological_process | carbohydrate derivative metabolic process |
B | 0001701 | biological_process | in utero embryonic development |
B | 0001707 | biological_process | mesoderm formation |
B | 0002639 | biological_process | positive regulation of immunoglobulin production |
B | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
B | 0005125 | molecular_function | cytokine activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006002 | biological_process | fructose 6-phosphate metabolic process |
B | 0006094 | biological_process | gluconeogenesis |
B | 0006096 | biological_process | glycolytic process |
B | 0007165 | biological_process | signal transduction |
B | 0007611 | biological_process | learning or memory |
B | 0008083 | molecular_function | growth factor activity |
B | 0010595 | biological_process | positive regulation of endothelial cell migration |
B | 0016853 | molecular_function | isomerase activity |
B | 0031625 | molecular_function | ubiquitin protein ligase binding |
B | 0032355 | biological_process | response to estradiol |
B | 0032570 | biological_process | response to progesterone |
B | 0033574 | biological_process | response to testosterone |
B | 0034101 | biological_process | erythrocyte homeostasis |
B | 0035902 | biological_process | response to immobilization stress |
B | 0035994 | biological_process | response to muscle stretch |
B | 0042593 | biological_process | glucose homeostasis |
B | 0043209 | cellular_component | myelin sheath |
B | 0043524 | biological_process | negative regulation of neuron apoptotic process |
B | 0046686 | biological_process | response to cadmium ion |
B | 0048029 | molecular_function | monosaccharide binding |
B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
B | 0060170 | cellular_component | ciliary membrane |
B | 0061620 | biological_process | glycolytic process through glucose-6-phosphate |
B | 0061621 | biological_process | canonical glycolysis |
B | 0097367 | molecular_function | carbohydrate derivative binding |
B | 0141199 | biological_process | GDP-mannose biosynthetic process from glucose |
B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 A 1601 |
Chain | Residue |
A | SER160 |
A | SER210 |
A | LYS211 |
A | THR212 |
A | THR215 |
A | HOH1763 |
A | HOH1869 |
A | HOH1915 |
A | HOH1937 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 1701 |
Chain | Residue |
A | ASP140 |
A | TRP141 |
A | LYS142 |
A | LYS241 |
A | HOH2203 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 1702 |
Chain | Residue |
A | ILE549 |
A | ARG553 |
B | GLY419 |
B | LYS423 |
B | LEU426 |
B | HOH1959 |
B | HOH1979 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 1703 |
Chain | Residue |
B | ARG135 |
B | TRP141 |
B | LYS142 |
B | HOH1948 |
B | HOH2227 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 1704 |
Chain | Residue |
A | GLY419 |
A | HIS422 |
A | LYS423 |
A | LEU426 |
A | HOH1847 |
A | HOH1941 |
B | ILE549 |
B | ARG553 |
Functional Information from PROSITE/UniProt
site_id | PS00174 |
Number of Residues | 18 |
Details | P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GiMWdinsFDQwGVElgK |
Chain | Residue | Details |
A | GLY502-LYS519 |
site_id | PS00765 |
Number of Residues | 14 |
Details | P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSLwSAIG |
Chain | Residue | Details |
A | ASP268-GLY281 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:15342241 |
Chain | Residue | Details |
A | SER359 | |
B | SER359 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:15342241 |
Chain | Residue | Details |
A | ALA390 | |
A | GLN520 | |
B | ALA390 | |
B | GLN520 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15342241, ECO:0000269|PubMed:16375918, ECO:0007744|PDB:1U0F, ECO:0007744|PDB:2CXS, ECO:0007744|PDB:2CXT |
Chain | Residue | Details |
A | SER160 | |
B | SER359 | |
B | ALA390 | |
B | GLN520 | |
A | LYS211 | |
A | GLY355 | |
A | SER359 | |
A | ALA390 | |
A | GLN520 | |
B | SER160 | |
B | LYS211 | |
B | GLY355 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P06744 |
Chain | Residue | Details |
A | ALA3 | |
B | ALA3 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06744 |
Chain | Residue | Details |
A | LEU13 | |
B | LEU13 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6P6V0 |
Chain | Residue | Details |
A | GLY87 | |
B | GLY87 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06744 |
Chain | Residue | Details |
A | ASN108 | |
B | ASN108 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P06744 |
Chain | Residue | Details |
A | PRO110 | |
B | PRO110 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337 |
Chain | Residue | Details |
A | GLY143 | |
B | GLY143 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000250|UniProtKB:P06744 |
Chain | Residue | Details |
A | ASN186 | |
B | ASN186 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q6P6V0 |
Chain | Residue | Details |
A | ALA251 | |
B | ALA251 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337 |
Chain | Residue | Details |
A | SER455 | |
B | SER455 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
Chain | Residue | Details |
A | PRO456 | |
B | PRO456 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1dqr |
Chain | Residue | Details |
A | HIS389 | |
B | GLY272 | |
B | ARG273 | |
B | LYS211 | |
B | GLU358 | |
B | LYS519 | |
B | GLU217 |
site_id | CSA2 |
Number of Residues | 7 |
Details | Annotated By Reference To The Literature 1dqr |
Chain | Residue | Details |
A | GLY272 | |
A | ARG273 | |
A | LYS211 | |
A | LYS519 | |
A | GLU358 | |
A | GLU217 | |
B | HIS389 |