2CXR
Crystal structure of mouse AMF / 6PG complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0001707 | biological_process | mesoderm formation |
| A | 0002639 | biological_process | positive regulation of immunoglobulin production |
| A | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0007611 | biological_process | learning or memory |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0010595 | biological_process | positive regulation of endothelial cell migration |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032355 | biological_process | response to estradiol |
| A | 0032570 | biological_process | response to progesterone |
| A | 0033574 | biological_process | response to testosterone |
| A | 0034101 | biological_process | erythrocyte homeostasis |
| A | 0035902 | biological_process | response to immobilization stress |
| A | 0035994 | biological_process | response to muscle stretch |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043209 | cellular_component | myelin sheath |
| A | 0046686 | biological_process | response to cadmium ion |
| A | 0048029 | molecular_function | monosaccharide binding |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0060170 | cellular_component | ciliary membrane |
| A | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
| A | 0061620 | biological_process | glycolytic process through glucose-6-phosphate |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| A | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
| A | 1904540 | biological_process | positive regulation of glycolytic process through fructose-6-phosphate |
| B | 0001701 | biological_process | in utero embryonic development |
| B | 0001707 | biological_process | mesoderm formation |
| B | 0002639 | biological_process | positive regulation of immunoglobulin production |
| B | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0007611 | biological_process | learning or memory |
| B | 0008083 | molecular_function | growth factor activity |
| B | 0010595 | biological_process | positive regulation of endothelial cell migration |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032355 | biological_process | response to estradiol |
| B | 0032570 | biological_process | response to progesterone |
| B | 0033574 | biological_process | response to testosterone |
| B | 0034101 | biological_process | erythrocyte homeostasis |
| B | 0035902 | biological_process | response to immobilization stress |
| B | 0035994 | biological_process | response to muscle stretch |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0043209 | cellular_component | myelin sheath |
| B | 0046686 | biological_process | response to cadmium ion |
| B | 0048029 | molecular_function | monosaccharide binding |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 0060170 | cellular_component | ciliary membrane |
| B | 0061615 | biological_process | glycolytic process through fructose-6-phosphate |
| B | 0061620 | biological_process | glycolytic process through glucose-6-phosphate |
| B | 0061621 | biological_process | canonical glycolysis |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 1904539 | biological_process | negative regulation of glycolytic process through fructose-6-phosphate |
| B | 1904540 | biological_process | positive regulation of glycolytic process through fructose-6-phosphate |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 6PG A 1601 |
| Chain | Residue |
| A | ILE157 |
| A | ARG273 |
| A | GLN354 |
| A | GLU358 |
| A | GLN512 |
| A | LYS519 |
| A | HOH1709 |
| A | HOH1757 |
| A | HOH1764 |
| A | HOH1774 |
| A | HOH1778 |
| A | GLY158 |
| A | HOH1853 |
| A | HOH1911 |
| B | HIS389 |
| A | GLY159 |
| A | SER160 |
| A | SER210 |
| A | LYS211 |
| A | THR212 |
| A | THR215 |
| A | GLY272 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 6PG B 2601 |
| Chain | Residue |
| A | HIS389 |
| B | ILE157 |
| B | GLY159 |
| B | SER160 |
| B | SER210 |
| B | LYS211 |
| B | THR212 |
| B | THR215 |
| B | GLY272 |
| B | ARG273 |
| B | GLN354 |
| B | GLU358 |
| B | GLN512 |
| B | HOH2643 |
| B | HOH2657 |
| B | HOH2684 |
| B | HOH2705 |
| B | HOH2748 |
| B | HOH2766 |
| B | HOH2775 |
| B | HOH2812 |
| B | HOH2920 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1701 |
| Chain | Residue |
| A | ASP140 |
| A | TRP141 |
| A | LYS142 |
| A | LYS241 |
| A | HOH1918 |
| A | HOH2064 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1702 |
| Chain | Residue |
| A | ILE549 |
| A | ARG553 |
| A | HOH1823 |
| A | HOH1887 |
| B | GLY419 |
| B | HIS422 |
| B | LYS423 |
| B | LEU426 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1703 |
| Chain | Residue |
| B | ARG135 |
| B | TRP141 |
| B | LYS142 |
| B | HOH2810 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1704 |
| Chain | Residue |
| A | GLY419 |
| A | HIS422 |
| A | LYS423 |
| A | LEU426 |
| A | HOH1873 |
| A | HOH1882 |
| B | ARG553 |
Functional Information from PROSITE/UniProt
| site_id | PS00174 |
| Number of Residues | 18 |
| Details | P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GiMWdinsFDQwGVElgK |
| Chain | Residue | Details |
| A | GLY502-LYS519 |
| site_id | PS00765 |
| Number of Residues | 14 |
| Details | P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSLwSAIG |
| Chain | Residue | Details |
| A | ASP268-GLY281 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15342241","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15342241","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15342241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16375918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1U0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P06744","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06744","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6P6V0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06744","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P06744","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"UniProtKB","id":"P06744","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P6V0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | HIS389 | |
| B | GLY272 | |
| B | ARG273 | |
| B | LYS211 | |
| B | GLU358 | |
| B | LYS519 | |
| B | GLU217 |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | GLY272 | |
| A | ARG273 | |
| A | LYS211 | |
| A | LYS519 | |
| A | GLU358 | |
| A | GLU217 | |
| B | HIS389 |
