2CWW

Crystal structure of Thermus thermophilus TTHA1280, a putative SAM-dependent RNA methyltransferase, in complex with S-adenosyl-L-homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005737	cellular_component	cytoplasm
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
B	0003723	molecular_function	RNA binding
B	0005737	cellular_component	cytoplasm
B	0008168	molecular_function	methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH A 500

Chain	Residue
A	TYR195
A	ALA266
A	ASP286
A	HOH501
A	ARG202
A	PHE217
A	SER218
A	TYR219
A	PHE223
A	ASP238
A	SER239
A	ASN265

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SAH B 501

Chain	Residue
B	TYR195
B	ARG202
B	PHE217
B	SER218
B	TYR219
B	PHE223
B	ASP238
B	SER239
B	ASN265
B	ALA266
B	ASP286
B	PRO288

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 400

Chain	Residue
A	PHE21
A	ARG88

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	ARG16
A	ARG42
A	PHE43
A	LEU44

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	114
Details	Domain: {"description":"PUA","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16511182","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16511182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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