Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 2001 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ANP A 1001 |
| Chain | Residue |
| A | TYR285 |
| A | VAL286 |
| A | ASP287 |
| A | MG2001 |
| A | HOH2009 |
| A | HOH2012 |
| A | HOH2052 |
| A | ASP226 |
| A | SER227 |
| A | ILE228 |
| A | ILE231 |
| A | LYS243 |
| A | ARG256 |
| A | ILE262 |
| A | ALA263 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CDP A 1002 |
| Chain | Residue |
| A | ALA201 |
| A | SER202 |
| A | SER217 |
| A | CYS218 |
| A | GLY247 |
| A | ASN426 |
| A | LEU427 |
| A | CYS428 |
| A | GLU430 |
| A | MET606 |
| A | PRO607 |
| A | THR608 |
| A | ALA609 |
| A | THR611 |
| A | HOH2006 |
Functional Information from PROSITE/UniProt
| site_id | PS00089 |
| Number of Residues | 23 |
| Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WdtLrkdimkhGVRNsltMApmP |
| Chain | Residue | Details |
| A | TRP585-PRO607 | |
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ISQkTIINMAADRSVyI |
| Chain | Residue | Details |
| A | ILE690-ILE706 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | ASN426 | |
| A | GLU430 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Cysteine radical intermediate |
| Chain | Residue | Details |
| A | CYS428 | |
| Chain | Residue | Details |
| A | LYS5 | |
| A | ALA263 | |
| A | ASN426 | |
| A | GLU430 | |
| A | THR608 | |
| A | GLU11 | |
| A | THR53 | |
| A | ASP57 | |
| A | SER202 | |
| A | SER217 | |
| A | ASP226 | |
| A | LYS243 | |
| A | ARG256 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for hydrogen atom transfer => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS218 | |
| A | CYS443 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Important for electron transfer => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR741 | |
| A | TYR742 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Interacts with thioredoxin/glutaredoxin => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS883 | |
| A | CYS886 | |
| Chain | Residue | Details |
| A | SER227 | |
| A | SER837 | |
| Chain | Residue | Details |
| A | SER816 | |
| Chain | Residue | Details |
| A | SER887 | |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS387 | |
| A | LYS853 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 3r1r |
| Chain | Residue | Details |
| A | CYS428 | |
| A | ASN426 | |
| A | CYS218 | |
| A | GLU430 | |
| A | CYS443 | |
