2CSE

Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000166	molecular_function	nucleotide binding
1	0001172	biological_process	RNA-templated transcription
1	0003723	molecular_function	RNA binding
1	0003968	molecular_function	RNA-directed RNA polymerase activity
1	0016740	molecular_function	transferase activity
1	0016779	molecular_function	nucleotidyltransferase activity
1	0019013	cellular_component	viral nucleocapsid
1	0019028	cellular_component	viral capsid
1	0019079	biological_process	viral genome replication
1	0032774	biological_process	RNA biosynthetic process
1	0034062	molecular_function	5'-3' RNA polymerase activity
1	0044423	cellular_component	virion component
1	0046872	molecular_function	metal ion binding
A	0019028	cellular_component	viral capsid
A	0020002	cellular_component	host cell plasma membrane
A	0033650	cellular_component	host cell mitochondrion
A	0039624	cellular_component	viral outer capsid
A	0044165	cellular_component	host cell endoplasmic reticulum
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046812	molecular_function	host cell surface binding
A	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
B	0019028	cellular_component	viral capsid
B	0020002	cellular_component	host cell plasma membrane
B	0033650	cellular_component	host cell mitochondrion
B	0039624	cellular_component	viral outer capsid
B	0044165	cellular_component	host cell endoplasmic reticulum
B	0044423	cellular_component	virion component
B	0046718	biological_process	symbiont entry into host cell
B	0046812	molecular_function	host cell surface binding
B	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
C	0019028	cellular_component	viral capsid
C	0020002	cellular_component	host cell plasma membrane
C	0033650	cellular_component	host cell mitochondrion
C	0039624	cellular_component	viral outer capsid
C	0044165	cellular_component	host cell endoplasmic reticulum
C	0044423	cellular_component	virion component
C	0046718	biological_process	symbiont entry into host cell
C	0046812	molecular_function	host cell surface binding
C	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
D	0003723	molecular_function	RNA binding
D	0005198	molecular_function	structural molecule activity
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0019028	cellular_component	viral capsid
D	0019058	biological_process	viral life cycle
D	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
D	0030430	cellular_component	host cell cytoplasm
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
D	0039624	cellular_component	viral outer capsid
D	0042025	cellular_component	host cell nucleus
D	0044423	cellular_component	virion component
D	0046872	molecular_function	metal ion binding
D	0052031	biological_process	symbiont-mediated perturbation of host defense response
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0003723	molecular_function	RNA binding
E	0005198	molecular_function	structural molecule activity
E	0006351	biological_process	DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0019028	cellular_component	viral capsid
E	0019058	biological_process	viral life cycle
E	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
E	0030430	cellular_component	host cell cytoplasm
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
E	0039624	cellular_component	viral outer capsid
E	0042025	cellular_component	host cell nucleus
E	0044423	cellular_component	virion component
E	0046872	molecular_function	metal ion binding
E	0052031	biological_process	symbiont-mediated perturbation of host defense response
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0003723	molecular_function	RNA binding
F	0005198	molecular_function	structural molecule activity
F	0006351	biological_process	DNA-templated transcription
F	0008270	molecular_function	zinc ion binding
F	0019028	cellular_component	viral capsid
F	0019058	biological_process	viral life cycle
F	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
F	0030430	cellular_component	host cell cytoplasm
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
F	0039624	cellular_component	viral outer capsid
F	0042025	cellular_component	host cell nucleus
F	0044423	cellular_component	virion component
F	0046872	molecular_function	metal ion binding
F	0052031	biological_process	symbiont-mediated perturbation of host defense response
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
G	0003723	molecular_function	RNA binding
G	0005198	molecular_function	structural molecule activity
G	0006351	biological_process	DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
G	0019028	cellular_component	viral capsid
G	0019058	biological_process	viral life cycle
G	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
G	0030430	cellular_component	host cell cytoplasm
G	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
G	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
G	0039624	cellular_component	viral outer capsid
G	0042025	cellular_component	host cell nucleus
G	0044423	cellular_component	virion component
G	0046872	molecular_function	metal ion binding
G	0052031	biological_process	symbiont-mediated perturbation of host defense response
G	0052170	biological_process	symbiont-mediated suppression of host innate immune response
H	0003723	molecular_function	RNA binding
H	0005198	molecular_function	structural molecule activity
H	0006351	biological_process	DNA-templated transcription
H	0008270	molecular_function	zinc ion binding
H	0019028	cellular_component	viral capsid
H	0019058	biological_process	viral life cycle
H	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
H	0030430	cellular_component	host cell cytoplasm
H	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
H	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
H	0039624	cellular_component	viral outer capsid
H	0042025	cellular_component	host cell nucleus
H	0044423	cellular_component	virion component
H	0046872	molecular_function	metal ion binding
H	0052031	biological_process	symbiont-mediated perturbation of host defense response
H	0052170	biological_process	symbiont-mediated suppression of host innate immune response
I	0003723	molecular_function	RNA binding
I	0005198	molecular_function	structural molecule activity
I	0006351	biological_process	DNA-templated transcription
I	0008270	molecular_function	zinc ion binding
I	0019028	cellular_component	viral capsid
I	0019058	biological_process	viral life cycle
I	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
I	0030430	cellular_component	host cell cytoplasm
I	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
I	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
I	0039624	cellular_component	viral outer capsid
I	0042025	cellular_component	host cell nucleus
I	0044423	cellular_component	virion component
I	0046872	molecular_function	metal ion binding
I	0052031	biological_process	symbiont-mediated perturbation of host defense response
I	0052170	biological_process	symbiont-mediated suppression of host innate immune response
J	0019028	cellular_component	viral capsid
J	0020002	cellular_component	host cell plasma membrane
J	0033650	cellular_component	host cell mitochondrion
J	0039624	cellular_component	viral outer capsid
J	0044165	cellular_component	host cell endoplasmic reticulum
J	0044423	cellular_component	virion component
J	0046718	biological_process	symbiont entry into host cell
J	0046812	molecular_function	host cell surface binding
J	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
K	0019028	cellular_component	viral capsid
K	0020002	cellular_component	host cell plasma membrane
K	0033650	cellular_component	host cell mitochondrion
K	0039624	cellular_component	viral outer capsid
K	0044165	cellular_component	host cell endoplasmic reticulum
K	0044423	cellular_component	virion component
K	0046718	biological_process	symbiont entry into host cell
K	0046812	molecular_function	host cell surface binding
K	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
L	0019028	cellular_component	viral capsid
L	0020002	cellular_component	host cell plasma membrane
L	0033650	cellular_component	host cell mitochondrion
L	0039624	cellular_component	viral outer capsid
L	0044165	cellular_component	host cell endoplasmic reticulum
L	0044423	cellular_component	virion component
L	0046718	biological_process	symbiont entry into host cell
L	0046812	molecular_function	host cell surface binding
L	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
M	0003723	molecular_function	RNA binding
M	0005198	molecular_function	structural molecule activity
M	0006351	biological_process	DNA-templated transcription
M	0008270	molecular_function	zinc ion binding
M	0019028	cellular_component	viral capsid
M	0019058	biological_process	viral life cycle
M	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
M	0030430	cellular_component	host cell cytoplasm
M	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
M	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
M	0039624	cellular_component	viral outer capsid
M	0042025	cellular_component	host cell nucleus
M	0044423	cellular_component	virion component
M	0046872	molecular_function	metal ion binding
M	0052031	biological_process	symbiont-mediated perturbation of host defense response
M	0052170	biological_process	symbiont-mediated suppression of host innate immune response
N	0003723	molecular_function	RNA binding
N	0005198	molecular_function	structural molecule activity
N	0006351	biological_process	DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0019028	cellular_component	viral capsid
N	0019058	biological_process	viral life cycle
N	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
N	0030430	cellular_component	host cell cytoplasm
N	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
N	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
N	0039624	cellular_component	viral outer capsid
N	0042025	cellular_component	host cell nucleus
N	0044423	cellular_component	virion component
N	0046872	molecular_function	metal ion binding
N	0052031	biological_process	symbiont-mediated perturbation of host defense response
N	0052170	biological_process	symbiont-mediated suppression of host innate immune response
O	0003723	molecular_function	RNA binding
O	0005198	molecular_function	structural molecule activity
O	0006351	biological_process	DNA-templated transcription
O	0008270	molecular_function	zinc ion binding
O	0019028	cellular_component	viral capsid
O	0019058	biological_process	viral life cycle
O	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
O	0030430	cellular_component	host cell cytoplasm
O	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
O	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
O	0039624	cellular_component	viral outer capsid
O	0042025	cellular_component	host cell nucleus
O	0044423	cellular_component	virion component
O	0046872	molecular_function	metal ion binding
O	0052031	biological_process	symbiont-mediated perturbation of host defense response
O	0052170	biological_process	symbiont-mediated suppression of host innate immune response
P	0019028	cellular_component	viral capsid
P	0020002	cellular_component	host cell plasma membrane
P	0033650	cellular_component	host cell mitochondrion
P	0039624	cellular_component	viral outer capsid
P	0044165	cellular_component	host cell endoplasmic reticulum
P	0044423	cellular_component	virion component
P	0046718	biological_process	symbiont entry into host cell
P	0046812	molecular_function	host cell surface binding
P	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
Q	0019028	cellular_component	viral capsid
Q	0020002	cellular_component	host cell plasma membrane
Q	0033650	cellular_component	host cell mitochondrion
Q	0039624	cellular_component	viral outer capsid
Q	0044165	cellular_component	host cell endoplasmic reticulum
Q	0044423	cellular_component	virion component
Q	0046718	biological_process	symbiont entry into host cell
Q	0046812	molecular_function	host cell surface binding
Q	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
R	0019028	cellular_component	viral capsid
R	0020002	cellular_component	host cell plasma membrane
R	0033650	cellular_component	host cell mitochondrion
R	0039624	cellular_component	viral outer capsid
R	0044165	cellular_component	host cell endoplasmic reticulum
R	0044423	cellular_component	virion component
R	0046718	biological_process	symbiont entry into host cell
R	0046812	molecular_function	host cell surface binding
R	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
S	0003723	molecular_function	RNA binding
S	0005198	molecular_function	structural molecule activity
S	0006351	biological_process	DNA-templated transcription
S	0008270	molecular_function	zinc ion binding
S	0019028	cellular_component	viral capsid
S	0019058	biological_process	viral life cycle
S	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
S	0030430	cellular_component	host cell cytoplasm
S	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
S	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
S	0039624	cellular_component	viral outer capsid
S	0042025	cellular_component	host cell nucleus
S	0044423	cellular_component	virion component
S	0046872	molecular_function	metal ion binding
S	0052031	biological_process	symbiont-mediated perturbation of host defense response
S	0052170	biological_process	symbiont-mediated suppression of host innate immune response
T	0019028	cellular_component	viral capsid
T	0020002	cellular_component	host cell plasma membrane
T	0033650	cellular_component	host cell mitochondrion
T	0039624	cellular_component	viral outer capsid
T	0044165	cellular_component	host cell endoplasmic reticulum
T	0044423	cellular_component	virion component
T	0046718	biological_process	symbiont entry into host cell
T	0046812	molecular_function	host cell surface binding
T	0140267	biological_process	symbiont entry into host cell via permeabilization of host membrane
U	0000166	molecular_function	nucleotide binding
U	0003824	molecular_function	catalytic activity
U	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
U	0004484	molecular_function	mRNA guanylyltransferase activity
U	0005524	molecular_function	ATP binding
U	0005525	molecular_function	GTP binding
U	0006370	biological_process	7-methylguanosine mRNA capping
U	0006397	biological_process	mRNA processing
U	0008168	molecular_function	methyltransferase activity
U	0016740	molecular_function	transferase activity
U	0016779	molecular_function	nucleotidyltransferase activity
U	0019028	cellular_component	viral capsid
U	0019030	cellular_component	icosahedral viral capsid
U	0032259	biological_process	methylation
U	0039624	cellular_component	viral outer capsid
U	0044423	cellular_component	virion component
U	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
V	0000166	molecular_function	nucleotide binding
V	0003724	molecular_function	RNA helicase activity
V	0004386	molecular_function	helicase activity
V	0005524	molecular_function	ATP binding
V	0006370	biological_process	7-methylguanosine mRNA capping
V	0006397	biological_process	mRNA processing
V	0008270	molecular_function	zinc ion binding
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0019028	cellular_component	viral capsid
V	0039616	cellular_component	T=2 icosahedral viral capsid
V	0039625	cellular_component	viral inner capsid
V	0044423	cellular_component	virion component
V	0046872	molecular_function	metal ion binding
W	0000166	molecular_function	nucleotide binding
W	0003724	molecular_function	RNA helicase activity
W	0004386	molecular_function	helicase activity
W	0005524	molecular_function	ATP binding
W	0006370	biological_process	7-methylguanosine mRNA capping
W	0006397	biological_process	mRNA processing
W	0008270	molecular_function	zinc ion binding
W	0016787	molecular_function	hydrolase activity
W	0016887	molecular_function	ATP hydrolysis activity
W	0019028	cellular_component	viral capsid
W	0039616	cellular_component	T=2 icosahedral viral capsid
W	0039625	cellular_component	viral inner capsid
W	0044423	cellular_component	virion component
W	0046872	molecular_function	metal ion binding
X	0019028	cellular_component	viral capsid
X	0039625	cellular_component	viral inner capsid
X	0044423	cellular_component	virion component
Y	0019028	cellular_component	viral capsid
Y	0039625	cellular_component	viral inner capsid
Y	0044423	cellular_component	virion component
Z	0019028	cellular_component	viral capsid
Z	0039625	cellular_component	viral inner capsid
Z	0044423	cellular_component	virion component

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cmh..ClgvVgslqrklkHlph..H

Chain	Residue	Details
S	CYS51-HIS71
V	CYS183-HIS203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Site: {"description":"Cleavage","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	220
Details	Zinc finger: {"description":"CCHC-type","evidences":[{"source":"UniProtKB","id":"P03527","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Involved in formation of the phosphoamide bond"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Zinc finger: {"description":"C2H2-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	11
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	42
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	31
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	237
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---