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2CMW

Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PO4 A1343
ChainResidue
AARG216
AGLN252
AGLY253
AHOH2287
AHOH2288
AHOH2289
AHOH2291
AHOH2292

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT A1344
ChainResidue
AASN63
ATYR105
AOLP1341
AOLP1342
AHOH2293
ALYS48

site_idAC3
Number of Residues17
DetailsBINDING SITE FOR RESIDUE OLP A1340
ChainResidue
AILE50
AGLY51
ALEU58
ALEU64
ALEU118
AGLU119
ALEU121
AGLY122
ALEU171
AILE186
APRO334
APRO336
AHOH2113
AHOH2281
AHOH2282
AHOH2283
AHOH2284

site_idAC4
Number of Residues12
DetailsBINDING SITE FOR RESIDUE OLP A1341
ChainResidue
ALYS62
AASN63
ALEU64
ATYR65
AASP127
AASP130
AILE333
APRO334
ATHR335
AOLP1342
AACT1344
AHOH2285

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE OLP A1342
ChainResidue
AGLY47
AGLY61
ALYS62
AASN63
AILE72
ATYR106
ASCS110
AASP130
APRO332
AOLP1341
AACT1344
AHOH2095
AHOH2273
AHOH2286

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGCGNFGELRlGknlytney..........VAIK
ChainResidueDetails
AILE50-LYS73

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDVKpeNFLI
ChainResidueDetails
ALEU160-ILE172

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP164

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE50
ALYS73

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER344

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP164
AGLU168

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP164
ALYS166

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP164
ALYS166
ATHR214

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP164
ALYS166
AASN169

226707

PDB entries from 2024-10-30

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