Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016311 | biological_process | dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CA A1282 |
| Chain | Residue |
| A | HIS54 |
| A | HOH2070 |
| A | HOH2071 |
| A | HOH2072 |
| B | LYS128 |
| B | HOH2149 |
| B | HOH2152 |
| B | HOH2154 |
| B | HOH2155 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B1282 |
| Chain | Residue |
| A | HOH2148 |
| A | HOH2152 |
| B | HIS54 |
| B | HOH2077 |
| B | HOH2079 |
| B | HOH2080 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRSG |
| Chain | Residue | Details |
| A | VAL213-GLY223 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Phosphocysteine intermediate |
| Chain | Residue | Details |
| A | CYS215 | |
| B | CYS215 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP181 | |
| B | ASP181 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS215 | |
| A | GLN262 | |
| B | CYS215 | |
| B | GLN262 | |
| Chain | Residue | Details |
| A | MET-5 | |
| B | MET-5 | |
| Chain | Residue | Details |
| A | TYR20 | |
| B | TYR20 | |
| Chain | Residue | Details |
| A | SER50 | |
| B | SER50 | |
| Chain | Residue | Details |
| A | TYR66 | |
| B | TYR66 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine; in reversibly inhibited form => ECO:0000269|PubMed:22169477 |
| Chain | Residue | Details |
| A | CYS215 | |
| B | CYS215 | |
| Chain | Residue | Details |
| A | SER242 | |
| A | SER243 | |
| B | SER242 | |
| B | SER243 | |
| Chain | Residue | Details |
| A | CYS215 | |
| A | SER216 | |
| B | CYS215 | |
| B | SER216 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| A | ARG221 | |
| A | ASP181 | |
| A | CYS215 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| B | ARG221 | |
| B | ASP181 | |
| B | CYS215 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| A | ARG221 | |
| A | ASP181 | |
| A | CYS215 | |
| A | SER222 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1d5r |
| Chain | Residue | Details |
| B | ARG221 | |
| B | ASP181 | |
| B | CYS215 | |
| B | SER222 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 469 |
| Chain | Residue | Details |
| A | ASP181 | proton shuttle (general acid/base) |
| A | CYS215 | covalent catalysis |
| A | ARG221 | activator, electrostatic stabiliser |
| A | SER222 | activator, electrostatic stabiliser |
| A | GLN262 | steric role |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 469 |
| Chain | Residue | Details |
| B | ASP181 | proton shuttle (general acid/base) |
| B | CYS215 | covalent catalysis |
| B | ARG221 | activator, electrostatic stabiliser |
| B | SER222 | activator, electrostatic stabiliser |
| B | GLN262 | steric role |
