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2CLW

Crystal structure of human ubiquitin-conjugating enzyme UbcH5B

Replaces:  2C4O
Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0019787molecular_functionubiquitin-like protein transferase activity
A0032991cellular_componentprotein-containing complex
A0036211biological_processprotein modification process
A0051865biological_processprotein autoubiquitination
A0061630molecular_functionubiquitin protein ligase activity
A0061631molecular_functionubiquitin conjugating enzyme activity
A0070062cellular_componentextracellular exosome
A0070936biological_processprotein K48-linked ubiquitination
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019787molecular_functionubiquitin-like protein transferase activity
B0032991cellular_componentprotein-containing complex
B0036211biological_processprotein modification process
B0051865biological_processprotein autoubiquitination
B0061630molecular_functionubiquitin protein ligase activity
B0061631molecular_functionubiquitin conjugating enzyme activity
B0070062cellular_componentextracellular exosome
B0070936biological_processprotein K48-linked ubiquitination
C0000209biological_processprotein polyubiquitination
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005829cellular_componentcytosol
C0006511biological_processubiquitin-dependent protein catabolic process
C0016567biological_processprotein ubiquitination
C0016740molecular_functiontransferase activity
C0019787molecular_functionubiquitin-like protein transferase activity
C0032991cellular_componentprotein-containing complex
C0036211biological_processprotein modification process
C0051865biological_processprotein autoubiquitination
C0061630molecular_functionubiquitin protein ligase activity
C0061631molecular_functionubiquitin conjugating enzyme activity
C0070062cellular_componentextracellular exosome
C0070936biological_processprotein K48-linked ubiquitination
D0000209biological_processprotein polyubiquitination
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005829cellular_componentcytosol
D0006511biological_processubiquitin-dependent protein catabolic process
D0016567biological_processprotein ubiquitination
D0016740molecular_functiontransferase activity
D0019787molecular_functionubiquitin-like protein transferase activity
D0032991cellular_componentprotein-containing complex
D0036211biological_processprotein modification process
D0051865biological_processprotein autoubiquitination
D0061630molecular_functionubiquitin protein ligase activity
D0061631molecular_functionubiquitin conjugating enzyme activity
D0070062cellular_componentextracellular exosome
D0070936biological_processprotein K48-linked ubiquitination
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1148
ChainResidue
ALYS133
AARG136
AHOH2083
AHOH2084

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 1149
ChainResidue
DALA96
DTHR98
DHOH2044
ACYS111
ATYR127
AARG131
AHOH2071
DARG5

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE GOL A 1150
ChainResidue
AHOH2056

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL D 1148
ChainResidue
BLYS133
BARG136
DASN11
DARG15

Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL
ChainResidueDetails
BTYR74-LEU89
ATYR74-LEU89

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133
ChainResidueDetails
BCYS85
CCYS85
DCYS85

227111

PDB entries from 2024-11-06

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