2CLC

CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GTP (2)

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003924	molecular_function	GTPase activity
X	0005525	molecular_function	GTP binding
X	0007165	biological_process	signal transduction
X	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG X 168

Chain	Residue
X	SER17
X	THR35
X	GTP1167
X	HOH2170
X	HOH2176

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG X 169

Chain	Residue
X	HOH2171
X	HOH2174
X	ASP108
X	HIS166
X	HOH2026
X	HOH2119

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE XY2 X 332

Chain	Residue
X	CYS32
X	TYR64
X	ASP69
X	GLN99
X	ARG102
X	VAL103
X	GLN131
X	HOH2143

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site_id	AC4
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GTP X 1167

Chain	Residue
X	GLY12
X	GLY13
X	VAL14
X	GLY15
X	LYS16
X	SER17
X	ALA18
X	PHE28
X	VAL29
X	ASP30
X	THR35
X	GLY60
X	ASN116
X	LYS117
X	ASP119
X	LEU120
X	SER145
X	ALA146
X	MG168
X	HOH2047
X	HOH2062
X	HOH2103
X	HOH2138
X	HOH2140
X	HOH2170
X	HOH2172
X	HOH2176
X	HOH2179

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:16698776

Chain	Residue	Details
X	GLY13
X	VAL29
X	ALA59
X	ASN116
X	SER145

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12

Chain	Residue	Details
X	MET1

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12

Chain	Residue	Details
X	THR2

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151

Chain	Residue	Details
X	SER118

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667

Chain	Residue	Details
X	THR35

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
X	GLN61

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