Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0006584 | biological_process | catecholamine metabolic process |
A | 0008171 | molecular_function | O-methyltransferase activity |
A | 0016206 | molecular_function | catechol O-methyltransferase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0006584 | biological_process | catecholamine metabolic process |
B | 0008171 | molecular_function | O-methyltransferase activity |
B | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A1216 |
Chain | Residue |
A | ASP141 |
A | ASP169 |
A | ASN170 |
A | BIE1218 |
A | HOH2205 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B1216 |
Chain | Residue |
B | HOH2186 |
B | ASP141 |
B | ASP169 |
B | ASN170 |
B | BIE1218 |
site_id | AC3 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE SAM A1217 |
Chain | Residue |
A | MET40 |
A | VAL42 |
A | GLY66 |
A | ALA67 |
A | TYR68 |
A | TYR71 |
A | SER72 |
A | GLU90 |
A | MET91 |
A | TYR95 |
A | GLY117 |
A | ALA118 |
A | SER119 |
A | GLN120 |
A | ASP141 |
A | HIS142 |
A | TRP143 |
A | BIE1218 |
A | HOH2285 |
A | HOH2286 |
A | HOH2287 |
site_id | AC4 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE SAM B1217 |
Chain | Residue |
B | MET40 |
B | ASN41 |
B | VAL42 |
B | GLY66 |
B | ALA67 |
B | TYR68 |
B | TYR71 |
B | SER72 |
B | MET89 |
B | GLU90 |
B | MET91 |
B | TYR95 |
B | GLY117 |
B | ALA118 |
B | SER119 |
B | GLN120 |
B | ASP141 |
B | HIS142 |
B | TRP143 |
B | ARG146 |
B | BIE1218 |
B | HOH2259 |
B | HOH2260 |
B | HOH2261 |
site_id | AC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE BIE A1218 |
Chain | Residue |
A | MET40 |
A | ASP141 |
A | HIS142 |
A | TRP143 |
A | LYS144 |
A | ASP169 |
A | ASN170 |
A | PRO174 |
A | GLU199 |
A | MG1216 |
A | SAM1217 |
A | BU31219 |
A | HOH2205 |
B | TRP38 |
B | BIE1218 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE BU3 A1219 |
Chain | Residue |
A | TRP143 |
A | LYS144 |
A | BIE1218 |
A | HOH2289 |
A | HOH2290 |
B | TRP38 |
B | BIE1218 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE BU3 A1220 |
Chain | Residue |
A | LYS144 |
A | ASP145 |
A | PRO177 |
A | ASP178 |
A | HOH2240 |
B | LYS36 |
B | GLU37 |
B | BU31219 |
B | HOH2070 |
B | HOH2072 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MES B1215 |
Chain | Residue |
A | TRP143 |
A | HOH2009 |
B | TRP143 |
B | LYS144 |
B | BIE1218 |
B | HOH2255 |
B | HOH2257 |
B | HOH2258 |
site_id | AC9 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE BIE B1218 |
Chain | Residue |
B | TRP143 |
B | LYS144 |
B | ASP169 |
B | ASN170 |
B | GLU199 |
B | MES1215 |
B | MG1216 |
B | SAM1217 |
B | HOH2186 |
A | BIE1218 |
A | BU31219 |
B | ASP141 |
B | HIS142 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE BU3 B1219 |
Chain | Residue |
A | PRO174 |
A | BU31220 |
A | HOH2232 |
B | LYS36 |
B | GLU37 |
B | HOH2262 |
B | HOH2263 |
B | HOH2264 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | VAL42 | |
A | SER72 | |
A | GLU90 | |
A | ASP141 | |
B | VAL42 | |
B | SER72 | |
B | GLU90 | |
B | ASP141 | |
Chain | Residue | Details |
A | GLU64 | |
A | MET91 | |
A | SER119 | |
B | GLU64 | |
B | MET91 | |
B | SER119 | |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY117 | |
B | GLU199 | |
A | LYS144 | |
A | ASP169 | |
A | ASN170 | |
A | GLU199 | |
B | GLY117 | |
B | LYS144 | |
B | ASP169 | |
B | ASN170 | |
Chain | Residue | Details |
A | SER216 | |
A | SER217 | |
A | SER221 | |
B | SER216 | |
B | SER217 | |
B | SER221 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1vid |
Chain | Residue | Details |
A | GLU199 | |
A | LYS144 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1vid |
Chain | Residue | Details |
B | GLU199 | |
B | LYS144 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 915 |
Chain | Residue | Details |
A | ASP141 | metal ligand |
A | LYS144 | proton shuttle (general acid/base) |
A | ASP169 | metal ligand |
A | ASN170 | metal ligand |
A | GLU199 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 915 |
Chain | Residue | Details |
B | ASP141 | metal ligand |
B | LYS144 | proton shuttle (general acid/base) |
B | ASP169 | metal ligand |
B | ASN170 | metal ligand |
B | GLU199 | electrostatic stabiliser |