2CI5
Crystal structure of Dimethylarginine Dimethylaminohydrolase I in complex with L-homocysteine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000052 | biological_process | citrulline metabolic process |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009891 | biological_process | positive regulation of biosynthetic process |
| A | 0016403 | molecular_function | dimethylargininase activity |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017014 | biological_process | protein nitrosylation |
| A | 0030235 | molecular_function | nitric-oxide synthase regulator activity |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000052 | biological_process | citrulline metabolic process |
| B | 0006525 | biological_process | arginine metabolic process |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009891 | biological_process | positive regulation of biosynthetic process |
| B | 0016403 | molecular_function | dimethylargininase activity |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017014 | biological_process | protein nitrosylation |
| B | 0030235 | molecular_function | nitric-oxide synthase regulator activity |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HCS A1281 |
| Chain | Residue |
| A | LEU29 |
| A | HOH2316 |
| A | ASP72 |
| A | PHE75 |
| A | ASP78 |
| A | ARG97 |
| A | ARG144 |
| A | VAL267 |
| A | ASP268 |
| A | CYS273 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HCS B1281 |
| Chain | Residue |
| B | LEU29 |
| B | ASP72 |
| B | PHE75 |
| B | ASP78 |
| B | ARG97 |
| B | ARG144 |
| B | VAL267 |
| B | ASP268 |
| B | CYS273 |
| B | HOH2308 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT B1282 |
| Chain | Residue |
| A | LYS195 |
| A | ILE199 |
| A | HOH2217 |
| B | ARG41 |
| B | ARG44 |
| B | GLN45 |
| B | LEU48 |
| B | SER260 |
| B | HOH2279 |
| B | HOH2318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"12441345","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jdw |
| Chain | Residue | Details |
| A | CYS273 | |
| A | HIS172 | |
| A | ASP126 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1jdw |
| Chain | Residue | Details |
| B | CYS273 | |
| B | HIS172 | |
| B | ASP126 |
