2CHN
Bacteroides thetaiotaomicron hexosaminidase with O-GlcNAcase activity- NAG-thiazoline complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006517 | biological_process | protein deglycosylation |
| A | 0015929 | molecular_function | hexosaminidase activity |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0102571 | molecular_function | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006517 | biological_process | protein deglycosylation |
| B | 0015929 | molecular_function | hexosaminidase activity |
| B | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0102571 | molecular_function | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A1717 |
| Chain | Residue |
| A | GLU32 |
| A | GLU61 |
| A | ASP64 |
| A | HOH2031 |
| A | HOH2047 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B1716 |
| Chain | Residue |
| B | HOH2046 |
| B | HOH2047 |
| B | GLU32 |
| B | GLU61 |
| B | ASP64 |
| B | HOH2027 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NGT A1718 |
| Chain | Residue |
| A | GLY135 |
| A | PHE136 |
| A | LYS166 |
| A | ASP242 |
| A | ASP243 |
| A | CYS278 |
| A | TYR282 |
| A | VAL314 |
| A | ASN339 |
| A | ASP344 |
| A | ASN372 |
| A | HOH2535 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NGT B1717 |
| Chain | Residue |
| B | GLY135 |
| B | PHE136 |
| B | LYS166 |
| B | ASP242 |
| B | ASP243 |
| B | CYS278 |
| B | TYR282 |
| B | VAL314 |
| B | ASN339 |
| B | ASP344 |
| B | ASN372 |
| B | HOH2556 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1719 |
| Chain | Residue |
| A | TYR137 |
| A | ASP344 |
| A | TYR345 |
| A | ARG347 |
| A | TYR550 |
| A | GLN551 |
| A | HOH2536 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B1718 |
| Chain | Residue |
| B | TYR137 |
| B | ASP344 |
| B | TYR345 |
| B | ARG347 |
| B | TYR550 |
| B | GLN551 |
| B | HOH2557 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C1720 |
| Chain | Residue |
| A | TYR356 |
| A | TRP400 |
| A | GLU438 |
| A | HOH2420 |
| A | HOH2421 |
| C | HOH2005 |
| C | HOH2006 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D1720 |
| Chain | Residue |
| B | LEU178 |
| B | PRO354 |
| B | TYR356 |
| B | TRP400 |
| B | GLU438 |
| D | HOH2003 |
| D | HOH2004 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01353, ECO:0000269|PubMed:16565725 |
| Chain | Residue | Details |
| A | ASP243 | |
| B | ASP243 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16565725 |
| Chain | Residue | Details |
| A | GLY135 | |
| B | ASP242 | |
| B | TYR282 | |
| B | TRP337 | |
| B | ASP344 | |
| B | ASN372 | |
| A | LYS166 | |
| A | ASP242 | |
| A | TYR282 | |
| A | TRP337 | |
| A | ASP344 | |
| A | ASN372 | |
| B | GLY135 | |
| B | LYS166 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qba |
| Chain | Residue | Details |
| A | ARG313 | |
| A | ASP312 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qba |
| Chain | Residue | Details |
| B | ARG313 | |
| B | ASP312 |
