2CB8
High resolution crystal structure of liganded human L-ACBP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000062 | molecular_function | fatty-acyl-CoA binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0030156 | molecular_function | benzodiazepine receptor binding |
| A | 0032994 | cellular_component | protein-lipid complex |
| A | 0036042 | molecular_function | long-chain fatty acyl-CoA binding |
| A | 0036151 | biological_process | phosphatidylcholine acyl-chain remodeling |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1903060 | biological_process | negative regulation of protein lipidation |
| A | 1905920 | biological_process | positive regulation of CoA-transferase activity |
| A | 2001140 | biological_process | positive regulation of phospholipid transport |
| B | 0000062 | molecular_function | fatty-acyl-CoA binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0030156 | molecular_function | benzodiazepine receptor binding |
| B | 0032994 | cellular_component | protein-lipid complex |
| B | 0036042 | molecular_function | long-chain fatty acyl-CoA binding |
| B | 0036151 | biological_process | phosphatidylcholine acyl-chain remodeling |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1903060 | biological_process | negative regulation of protein lipidation |
| B | 1905920 | biological_process | positive regulation of CoA-transferase activity |
| B | 2001140 | biological_process | positive regulation of phospholipid transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1089 |
| Chain | Residue |
| A | HIS31 |
| A | HOH2150 |
| A | HOH2151 |
| B | GLU7 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1090 |
| Chain | Residue |
| A | MYA1088 |
| A | ZN1093 |
| A | MYA1094 |
| A | SO41095 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1091 |
| Chain | Residue |
| A | HIS15 |
| A | ASP22 |
| A | MYA1094 |
| A | GLU11 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1092 |
| Chain | Residue |
| A | SER2 |
| A | GLU68 |
| A | HOH2152 |
| B | ASP69 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1093 |
| Chain | Residue |
| A | MYA1088 |
| A | ZN1090 |
| A | MYA1094 |
| A | SO41095 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1095 |
| Chain | Residue |
| A | MYA1088 |
| A | ZN1090 |
| A | ZN1093 |
| A | MYA1094 |
| A | ZN1096 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN A1096 |
| Chain | Residue |
| A | MYA1094 |
| A | SO41095 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B1090 |
| Chain | Residue |
| A | GLU23 |
| B | GLU11 |
| B | HIS15 |
| B | HOH2131 |
| B | HOH2132 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B1091 |
| Chain | Residue |
| A | GLU7 |
| B | MYA1088 |
| B | HOH2133 |
| B | HOH2134 |
| site_id | BC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE MYA A1088 |
| Chain | Residue |
| A | ALA10 |
| A | ARG14 |
| A | ILE28 |
| A | TYR29 |
| A | TYR32 |
| A | LYS33 |
| A | LYS55 |
| A | TYR74 |
| A | ZN1090 |
| A | ZN1093 |
| A | MYA1094 |
| A | SO41095 |
| A | HOH2026 |
| A | HOH2100 |
| A | HOH2106 |
| A | HOH2143 |
| A | HOH2144 |
| A | HOH2145 |
| A | HOH2146 |
| A | HOH2147 |
| A | HOH2148 |
| A | HOH2149 |
| B | MYA1088 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MYA A1094 |
| Chain | Residue |
| A | GLU11 |
| A | ARG14 |
| A | HIS15 |
| A | LYS19 |
| A | ASP22 |
| A | THR51 |
| A | MYA1088 |
| A | ZN1090 |
| A | ZN1091 |
| A | ZN1093 |
| A | SO41095 |
| A | ZN1096 |
| A | HOH2025 |
| A | HOH2106 |
| A | HOH2153 |
| A | HOH2154 |
| A | HOH2155 |
| B | MYA1088 |
| site_id | BC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE MYA B1088 |
| Chain | Residue |
| B | MYA1089 |
| B | ZN1091 |
| B | HOH2088 |
| B | HOH2123 |
| B | HOH2124 |
| B | HOH2125 |
| B | HOH2126 |
| B | HOH2127 |
| B | HOH2128 |
| B | HOH2129 |
| B | HOH2130 |
| B | HOH2133 |
| B | HOH2134 |
| A | ALA4 |
| A | GLU7 |
| A | LYS8 |
| A | GLU11 |
| A | ARG14 |
| A | LYS19 |
| A | ASP22 |
| A | ARG44 |
| A | LYS53 |
| A | ALA54 |
| A | ASP57 |
| A | MYA1088 |
| A | MYA1094 |
| A | HOH2114 |
| B | ALA10 |
| B | ARG14 |
| B | ILE28 |
| B | TYR29 |
| B | TYR32 |
| B | LYS33 |
| B | LYS55 |
| B | TYR74 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MYA B1089 |
| Chain | Residue |
| B | VAL13 |
| B | ARG14 |
| B | LEU16 |
| B | LYS19 |
| B | PRO20 |
| B | MET25 |
| B | MYA1088 |
| B | MXE1092 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MXE B1092 |
| Chain | Residue |
| A | ASP39 |
| A | THR65 |
| A | HOH2077 |
| B | MYA1089 |
| B | HOH2045 |
Functional Information from PROSITE/UniProt
| site_id | PS00880 |
| Number of Residues | 19 |
| Details | ACB_1 Acyl-CoA-binding (ACB) domain signature. PSdEeMlfIYGhYKQATvG |
| Chain | Residue | Details |
| A | PRO20-GLY38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17044054, ECO:0007744|PDB:2CB8 |
| Chain | Residue | Details |
| A | HIS15 | |
| A | GLY30 | |
| A | TRP56 | |
| A | ILE75 | |
| B | HIS15 | |
| B | GLY30 | |
| B | TRP56 | |
| B | ILE75 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0000269|PubMed:3525533, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | GLN3 | |
| B | GLN3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P31786 |
| Chain | Residue | Details |
| A | ALA9 | |
| A | TRP56 | |
| A | VAL78 | |
| B | ALA9 | |
| B | TRP56 | |
| B | VAL78 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P31786 |
| Chain | Residue | Details |
| A | THR18 | |
| B | THR18 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | PRO20 | |
| B | PRO20 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | GLY30 | |
| B | GLY30 |
