2CB8

High resolution crystal structure of liganded human L-ACBP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0006631	biological_process	fatty acid metabolic process
A	0008289	molecular_function	lipid binding
A	0030156	molecular_function	benzodiazepine receptor binding
A	0032994	cellular_component	protein-lipid complex
A	0036042	molecular_function	long-chain fatty acyl-CoA binding
A	0036151	biological_process	phosphatidylcholine acyl-chain remodeling
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	2001140	biological_process	positive regulation of phospholipid transport
B	0000062	molecular_function	fatty-acyl-CoA binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0006631	biological_process	fatty acid metabolic process
B	0008289	molecular_function	lipid binding
B	0030156	molecular_function	benzodiazepine receptor binding
B	0032994	cellular_component	protein-lipid complex
B	0036042	molecular_function	long-chain fatty acyl-CoA binding
B	0036151	biological_process	phosphatidylcholine acyl-chain remodeling
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	2001140	biological_process	positive regulation of phospholipid transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1089

Chain	Residue
A	HIS31
A	HOH2150
A	HOH2151
B	GLU7

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1090

Chain	Residue
A	MYA1088
A	ZN1093
A	MYA1094
A	SO41095

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1091

Chain	Residue
A	HIS15
A	ASP22
A	MYA1094
A	GLU11

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1092

Chain	Residue
A	SER2
A	GLU68
A	HOH2152
B	ASP69

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1093

Chain	Residue
A	MYA1088
A	ZN1090
A	MYA1094
A	SO41095

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1095

Chain	Residue
A	MYA1088
A	ZN1090
A	ZN1093
A	MYA1094
A	ZN1096

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A1096

Chain	Residue
A	MYA1094
A	SO41095

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B1090

Chain	Residue
A	GLU23
B	GLU11
B	HIS15
B	HOH2131
B	HOH2132

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1091

Chain	Residue
A	GLU7
B	MYA1088
B	HOH2133
B	HOH2134

---

site_id	BC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE MYA A1088

Chain	Residue
A	ALA10
A	ARG14
A	ILE28
A	TYR29
A	TYR32
A	LYS33
A	LYS55
A	TYR74
A	ZN1090
A	ZN1093
A	MYA1094
A	SO41095
A	HOH2026
A	HOH2100
A	HOH2106
A	HOH2143
A	HOH2144
A	HOH2145
A	HOH2146
A	HOH2147
A	HOH2148
A	HOH2149
B	MYA1088

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE MYA A1094

Chain	Residue
A	GLU11
A	ARG14
A	HIS15
A	LYS19
A	ASP22
A	THR51
A	MYA1088
A	ZN1090
A	ZN1091
A	ZN1093
A	SO41095
A	ZN1096
A	HOH2025
A	HOH2106
A	HOH2153
A	HOH2154
A	HOH2155
B	MYA1088

---

site_id	BC3
Number of Residues	35
Details	BINDING SITE FOR RESIDUE MYA B1088

Chain	Residue
B	MYA1089
B	ZN1091
B	HOH2088
B	HOH2123
B	HOH2124
B	HOH2125
B	HOH2126
B	HOH2127
B	HOH2128
B	HOH2129
B	HOH2130
B	HOH2133
B	HOH2134
A	ALA4
A	GLU7
A	LYS8
A	GLU11
A	ARG14
A	LYS19
A	ASP22
A	ARG44
A	LYS53
A	ALA54
A	ASP57
A	MYA1088
A	MYA1094
A	HOH2114
B	ALA10
B	ARG14
B	ILE28
B	TYR29
B	TYR32
B	LYS33
B	LYS55
B	TYR74

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MYA B1089

Chain	Residue
B	VAL13
B	ARG14
B	LEU16
B	LYS19
B	PRO20
B	MET25
B	MYA1088
B	MXE1092

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MXE B1092

Chain	Residue
A	ASP39
A	THR65
A	HOH2077
B	MYA1089
B	HOH2045

---

Functional Information from PROSITE/UniProt

site_id	PS00880
Number of Residues	19
Details	ACB_1 Acyl-CoA-binding (ACB) domain signature. PSdEeMlfIYGhYKQATvG

Chain	Residue	Details
A	PRO20-GLY38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	85
Details	Domain: {"description":"ACB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00573","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17044054","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CB8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"3525533","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P31786","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P31786","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---