2CAJ
NikR from Helicobacter pylori in closed trans-conformation and nickel bound to 4 intermediary sites
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0010045 | biological_process | response to nickel cation |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0010045 | biological_process | response to nickel cation |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B1150 |
| Chain | Residue |
| A | HIS101 |
| B | GLN87 |
| B | HIS93 |
| B | NI1151 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI B1151 |
| Chain | Residue |
| A | HIS74 |
| B | HIS88 |
| B | CL1150 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI B1152 |
| Chain | Residue |
| B | HIS75 |
| B | HIS101 |
| A | HIS88 |
| B | HIS74 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1142 |
| Chain | Residue |
| A | GLU78 |
| A | GLN81 |
| A | ARG82 |
| A | HOH2016 |
| A | HOH2028 |
| B | ARG77 |
| B | GLU78 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A1143 |
| Chain | Residue |
| A | LEU130 |
| A | ARG131 |
| A | GLY132 |
| A | VAL133 |
| A | HOH2029 |
| A | HOH2030 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1144 |
| Chain | Residue |
| A | ASN80 |
| A | MET83 |
| A | GLN87 |
| A | THR97 |
| A | GLU109 |
| A | ILE111 |
| A | HOH2031 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A1145 |
| Chain | Residue |
| A | VAL94 |
| A | LEU95 |
| B | ILE100 |
| B | HIS101 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B1148 |
| Chain | Residue |
| B | ASN80 |
| B | MET83 |
| B | GLU109 |
| B | HOH2033 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B1149 |
| Chain | Residue |
| A | GLN81 |
| A | ASP85 |
| A | HIS88 |
| B | HIS74 |
| B | HIS75 |
| B | ARG77 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00476","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
