Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2C9T

Crystal Structure Of Acetylcholine Binding Protein (AChBP) From Aplysia Californica In Complex With alpha-Conotoxin ImI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005515	molecular_function	protein binding
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0005515	molecular_function	protein binding
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0005515	molecular_function	protein binding
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0005515	molecular_function	protein binding
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0005515	molecular_function	protein binding
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0005515	molecular_function	protein binding
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 K 13

Chain	Residue
K	TRP10
K	ARG11
K	CYS12

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NH2 M 13

Chain	Residue
M	ALA9
M	TRP10
M	ARG11
M	CYS12

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NH2 O 13

Chain	Residue
O	ARG11
O	CYS12
O	ALA9
O	TRP10

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NH2 P 13

Chain	Residue
P	ARG11
P	CYS12

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 Q 13

Chain	Residue
Q	ARG11
Q	CYS12
Q	HOH2003

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 R 13

Chain	Residue
R	TRP10
R	ARG11
R	CYS12

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 S 13

Chain	Residue
J	ARG57
S	ALA9
S	CYS12

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NH2 T 13

Chain	Residue
F	ARG57
T	ALA9
T	CYS12

Functional Information from PROSITE/UniProt

site_id	PS60014
Number of Residues	11
Details	ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCSdPRCA....WRC

Chain	Residue	Details
K	CYS2-CYS12

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI7
Number of Residues	88
Details	Peptide: {"description":"Alpha-conotoxin ImI","featureId":"PRO_0000034877","evidences":[{"source":"PubMed","id":"8206995","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Site: {"description":"Important for binding to human alpha-7 nAChR","evidences":[{"source":"PubMed","id":"15609996","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Cysteine amide","evidences":[{"source":"PubMed","id":"8206995","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)