Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2C9O

3D Structure of the human RuvB-like helicase RuvBL1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000492biological_processbox C/D snoRNP assembly
A0000723biological_processtelomere maintenance
A0000786cellular_componentnucleosome
A0000812cellular_componentSwr1 complex
A0001094molecular_functionTFIID-class transcription factor complex binding
A0003678molecular_functionDNA helicase activity
A0003713molecular_functiontranscription coactivator activity
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006275biological_processregulation of DNA replication
A0006281biological_processDNA repair
A0006282biological_processregulation of DNA repair
A0006310biological_processDNA recombination
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006974biological_processDNA damage response
A0007283biological_processspermatogenesis
A0008094molecular_functionATP-dependent activity, acting on DNA
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017025molecular_functionTBP-class protein binding
A0031011cellular_componentIno80 complex
A0033044biological_processregulation of chromosome organization
A0035267cellular_componentNuA4 histone acetyltransferase complex
A0036064cellular_componentciliary basal body
A0042981biological_processregulation of apoptotic process
A0043531molecular_functionADP binding
A0045296molecular_functioncadherin binding
A0045739biological_processpositive regulation of DNA repair
A0045893biological_processpositive regulation of DNA-templated transcription
A0045995biological_processregulation of embryonic development
A0050821biological_processprotein stabilization
A0051117molecular_functionATPase binding
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060382biological_processregulation of DNA strand elongation
A0070062cellular_componentextracellular exosome
A0071339cellular_componentMLL1 complex
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0090671biological_processtelomerase RNA localization to Cajal body
A0097255cellular_componentR2TP complex
A0101031cellular_componentprotein folding chaperone complex
A0120293cellular_componentdynein axonemal particle
A1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
A1905168biological_processpositive regulation of double-strand break repair via homologous recombination
A1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
A1990904cellular_componentribonucleoprotein complex
A2000779biological_processregulation of double-strand break repair
B0000166molecular_functionnucleotide binding
B0000492biological_processbox C/D snoRNP assembly
B0000723biological_processtelomere maintenance
B0000786cellular_componentnucleosome
B0000812cellular_componentSwr1 complex
B0001094molecular_functionTFIID-class transcription factor complex binding
B0003678molecular_functionDNA helicase activity
B0003713molecular_functiontranscription coactivator activity
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006275biological_processregulation of DNA replication
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006310biological_processDNA recombination
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006974biological_processDNA damage response
B0007283biological_processspermatogenesis
B0008094molecular_functionATP-dependent activity, acting on DNA
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017025molecular_functionTBP-class protein binding
B0031011cellular_componentIno80 complex
B0033044biological_processregulation of chromosome organization
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0036064cellular_componentciliary basal body
B0042981biological_processregulation of apoptotic process
B0043531molecular_functionADP binding
B0045296molecular_functioncadherin binding
B0045739biological_processpositive regulation of DNA repair
B0045893biological_processpositive regulation of DNA-templated transcription
B0045995biological_processregulation of embryonic development
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0060382biological_processregulation of DNA strand elongation
B0070062cellular_componentextracellular exosome
B0071339cellular_componentMLL1 complex
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0090671biological_processtelomerase RNA localization to Cajal body
B0097255cellular_componentR2TP complex
B0101031cellular_componentprotein folding chaperone complex
B0120293cellular_componentdynein axonemal particle
B1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
B1990904cellular_componentribonucleoprotein complex
B2000779biological_processregulation of double-strand break repair
C0000166molecular_functionnucleotide binding
C0000492biological_processbox C/D snoRNP assembly
C0000723biological_processtelomere maintenance
C0000786cellular_componentnucleosome
C0000812cellular_componentSwr1 complex
C0001094molecular_functionTFIID-class transcription factor complex binding
C0003678molecular_functionDNA helicase activity
C0003713molecular_functiontranscription coactivator activity
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006275biological_processregulation of DNA replication
C0006281biological_processDNA repair
C0006282biological_processregulation of DNA repair
C0006310biological_processDNA recombination
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006974biological_processDNA damage response
C0007283biological_processspermatogenesis
C0008094molecular_functionATP-dependent activity, acting on DNA
C0016020cellular_componentmembrane
C0016363cellular_componentnuclear matrix
C0016607cellular_componentnuclear speck
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017025molecular_functionTBP-class protein binding
C0031011cellular_componentIno80 complex
C0033044biological_processregulation of chromosome organization
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0036064cellular_componentciliary basal body
C0042981biological_processregulation of apoptotic process
C0043531molecular_functionADP binding
C0045296molecular_functioncadherin binding
C0045739biological_processpositive regulation of DNA repair
C0045893biological_processpositive regulation of DNA-templated transcription
C0045995biological_processregulation of embryonic development
C0050821biological_processprotein stabilization
C0051117molecular_functionATPase binding
C0051301biological_processcell division
C0051726biological_processregulation of cell cycle
C0060382biological_processregulation of DNA strand elongation
C0070062cellular_componentextracellular exosome
C0071339cellular_componentMLL1 complex
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0090671biological_processtelomerase RNA localization to Cajal body
C0097255cellular_componentR2TP complex
C0101031cellular_componentprotein folding chaperone complex
C0120293cellular_componentdynein axonemal particle
C1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990062cellular_componentRPAP3/R2TP/prefoldin-like complex
C1990904cellular_componentribonucleoprotein complex
C2000779biological_processregulation of double-strand break repair
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE ADP A1450
ChainResidue
ASER17
AGLY75
ALYS76
ATHR77
AALA78
ATYR366
AILE374
ALEU403
AARG404
AHOH2051
AHOH2089
AHIS18
AHOH2090
AHOH2091
AHIS20
AGLY38
ALEU39
AVAL40
APRO72
AGLY73
ATHR74

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ADP B1449
ChainResidue
BSER17
BHIS18
BHIS20
BGLY38
BLEU39
BVAL40
BPRO71
BGLY73
BTHR74
BGLY75
BLYS76
BTHR77
BALA78
BTYR366
BILE374
BLEU403
BARG404
BHOH2045

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ADP C1450
ChainResidue
CSER17
CHIS18
CHIS20
CGLY38
CLEU39
CVAL40
CGLY73
CTHR74
CGLY75
CLYS76
CTHR77
CALA78
CTYR366
CILE374
CLEU403
CARG404
CHOH2020
CHOH2021
CHOH2022

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY70
BGLY70
CGLY70

site_idSWS_FT_FI2
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS453
BLYS453
CLYS453

site_idSWS_FT_FI3
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS2
BLYS2
CLYS2

site_idSWS_FT_FI4
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS445
BLYS445
CLYS445

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS225
BLYS225
CLYS225

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hqc
ChainResidueDetails
ATHR345
AARG404

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hqc
ChainResidueDetails
BTHR345
BARG404

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hqc
ChainResidueDetails
CTHR345
CARG404

237735

PDB entries from 2025-06-18

PDB statisticsPDBj update infoContact PDBjnumon