2C95
Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001520 | cellular_component | outer dense fiber |
| A | 0004017 | molecular_function | AMP kinase activity |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006172 | biological_process | ADP biosynthetic process |
| A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| A | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| A | 0036126 | cellular_component | sperm flagellum |
| A | 0046033 | biological_process | AMP metabolic process |
| A | 0046034 | biological_process | ATP metabolic process |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| A | 0047506 | molecular_function | dAMP kinase activity |
| A | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001520 | cellular_component | outer dense fiber |
| B | 0004017 | molecular_function | AMP kinase activity |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006172 | biological_process | ADP biosynthetic process |
| B | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| B | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019205 | molecular_function | nucleobase-containing compound kinase activity |
| B | 0036126 | cellular_component | sperm flagellum |
| B | 0046033 | biological_process | AMP metabolic process |
| B | 0046034 | biological_process | ATP metabolic process |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0047506 | molecular_function | dAMP kinase activity |
| B | 0050145 | molecular_function | nucleoside monophosphate kinase activity |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE B4P A1195 |
| Chain | Residue |
| A | PRO17 |
| A | LEU43 |
| A | ARG44 |
| A | MET61 |
| A | GLN65 |
| A | VAL67 |
| A | GLY94 |
| A | TYR95 |
| A | ARG97 |
| A | GLN101 |
| A | ARG128 |
| A | GLY18 |
| A | ARG132 |
| A | ARG138 |
| A | ARG149 |
| A | ARG167 |
| A | GLY177 |
| A | SER178 |
| A | VAL179 |
| A | HOH2040 |
| A | HOH2065 |
| A | HOH2159 |
| A | SER19 |
| A | HOH2179 |
| A | HOH2180 |
| A | HOH2181 |
| A | HOH2182 |
| A | HOH2183 |
| A | HOH2184 |
| A | HOH2185 |
| A | HOH2186 |
| A | HOH2187 |
| A | HOH2189 |
| A | GLY20 |
| A | HOH2190 |
| A | LYS21 |
| A | GLY22 |
| A | THR23 |
| A | THR39 |
| A | GLY40 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MLI A1196 |
| Chain | Residue |
| A | GLU62 |
| A | GLY137 |
| A | ARG138 |
| A | VAL139 |
| A | ASP140 |
| A | HOH2191 |
| B | HOH2120 |
| site_id | AC3 |
| Number of Residues | 42 |
| Details | BINDING SITE FOR RESIDUE B4P B1196 |
| Chain | Residue |
| B | PRO17 |
| B | GLY18 |
| B | SER19 |
| B | GLY20 |
| B | LYS21 |
| B | GLY22 |
| B | THR23 |
| B | THR39 |
| B | GLY40 |
| B | LEU43 |
| B | ARG44 |
| B | MET61 |
| B | GLN65 |
| B | VAL67 |
| B | GLY94 |
| B | TYR95 |
| B | ARG97 |
| B | GLN101 |
| B | ARG128 |
| B | ARG132 |
| B | ARG138 |
| B | ARG149 |
| B | ARG167 |
| B | GLY177 |
| B | SER178 |
| B | VAL179 |
| B | HOH2067 |
| B | HOH2070 |
| B | HOH2095 |
| B | HOH2175 |
| B | HOH2176 |
| B | HOH2177 |
| B | HOH2178 |
| B | HOH2179 |
| B | HOH2180 |
| B | HOH2181 |
| B | HOH2182 |
| B | HOH2183 |
| B | HOH2184 |
| B | HOH2185 |
| B | HOH2186 |
| B | HOH2187 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MLI B1197 |
| Chain | Residue |
| B | SER58 |
| B | MET61 |
| B | ASP140 |
| B | HOH2189 |
Functional Information from PROSITE/UniProt
| site_id | PS00113 |
| Number of Residues | 12 |
| Details | ADENYLATE_KINASE Adenylate kinase signature. FLIDGYPRevqQ |
| Chain | Residue | Details |
| A | PHE90-GLN101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|Ref.12, ECO:0000269|Ref.13 |
| Chain | Residue | Details |
| A | GLY18 | |
| A | GLY177 | |
| B | GLY18 | |
| B | THR39 | |
| B | ARG44 | |
| B | GLN65 | |
| B | GLY94 | |
| B | GLN101 | |
| B | ARG132 | |
| B | ARG138 | |
| B | ARG149 | |
| A | THR39 | |
| B | GLY177 | |
| A | ARG44 | |
| A | GLN65 | |
| A | GLY94 | |
| A | GLN101 | |
| A | ARG132 | |
| A | ARG138 | |
| A | ARG149 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000255|HAMAP-Rule:MF_03171, ECO:0000269|PubMed:183954 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER38 | |
| B | SER38 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1zio |
| Chain | Residue | Details |
| A | ARG138 | |
| A | LYS21 | |
| A | ASP140 | |
| A | ARG149 | |
| A | ASP141 | |
| A | ARG132 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1zio |
| Chain | Residue | Details |
| B | ARG138 | |
| B | LYS21 | |
| B | ASP140 | |
| B | ARG149 | |
| B | ASP141 | |
| B | ARG132 |
