2C91
mouse succinic semialdehyde reductase, AKR7A5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005790 | cellular_component | smooth endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005790 | cellular_component | smooth endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0005635 | cellular_component | nuclear envelope |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005790 | cellular_component | smooth endoplasmic reticulum |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005829 | cellular_component | cytosol |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005790 | cellular_component | smooth endoplasmic reticulum |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0005829 | cellular_component | cytosol |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| E | 0005635 | cellular_component | nuclear envelope |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005790 | cellular_component | smooth endoplasmic reticulum |
| E | 0005794 | cellular_component | Golgi apparatus |
| E | 0005829 | cellular_component | cytosol |
| E | 0006629 | biological_process | lipid metabolic process |
| E | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| F | 0005635 | cellular_component | nuclear envelope |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005790 | cellular_component | smooth endoplasmic reticulum |
| F | 0005794 | cellular_component | Golgi apparatus |
| F | 0005829 | cellular_component | cytosol |
| F | 0006629 | biological_process | lipid metabolic process |
| F | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| G | 0005635 | cellular_component | nuclear envelope |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005790 | cellular_component | smooth endoplasmic reticulum |
| G | 0005794 | cellular_component | Golgi apparatus |
| G | 0005829 | cellular_component | cytosol |
| G | 0006629 | biological_process | lipid metabolic process |
| G | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| H | 0005635 | cellular_component | nuclear envelope |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005790 | cellular_component | smooth endoplasmic reticulum |
| H | 0005794 | cellular_component | Golgi apparatus |
| H | 0005829 | cellular_component | cytosol |
| H | 0006629 | biological_process | lipid metabolic process |
| H | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| I | 0005635 | cellular_component | nuclear envelope |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005790 | cellular_component | smooth endoplasmic reticulum |
| I | 0005794 | cellular_component | Golgi apparatus |
| I | 0005829 | cellular_component | cytosol |
| I | 0006629 | biological_process | lipid metabolic process |
| I | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| I | 0016491 | molecular_function | oxidoreductase activity |
| J | 0005635 | cellular_component | nuclear envelope |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005790 | cellular_component | smooth endoplasmic reticulum |
| J | 0005794 | cellular_component | Golgi apparatus |
| J | 0005829 | cellular_component | cytosol |
| J | 0006629 | biological_process | lipid metabolic process |
| J | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| J | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 364 |
| Chain | Residue |
| A | PRO76 |
| A | TRP77 |
| A | GLU78 |
| A | GLY79 |
| A | HOH2222 |
| A | HOH2223 |
| I | TRP77 |
| I | GLU78 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 J 367 |
| Chain | Residue |
| G | TRP77 |
| G | GLU78 |
| J | TRP77 |
| J | GLU78 |
| J | GLY79 |
| J | HOH2200 |
| J | HOH2201 |
| J | HOH2202 |
| G | PRO76 |
| site_id | AC3 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE NAP A 350 |
| Chain | Residue |
| A | GLY11 |
| A | THR12 |
| A | MET13 |
| A | ASP40 |
| A | TYR45 |
| A | HIS109 |
| A | SER139 |
| A | ASN140 |
| A | GLN165 |
| A | TYR193 |
| A | ASN194 |
| A | PRO195 |
| A | LEU196 |
| A | ALA197 |
| A | GLY198 |
| A | GLY199 |
| A | THR202 |
| A | LYS204 |
| A | TYR205 |
| A | GLY217 |
| A | ARG218 |
| A | TYR228 |
| A | ILE282 |
| A | LEU283 |
| A | GLY284 |
| A | MET285 |
| A | SER286 |
| A | GLN290 |
| A | GLN293 |
| A | ASN294 |
| A | ARG327 |
| A | TLA360 |
| A | HOH2007 |
| A | HOH2113 |
| A | HOH2213 |
| A | HOH2214 |
| A | HOH2215 |
| A | HOH2216 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TLA A 360 |
| Chain | Residue |
| A | MET13 |
| A | TYR45 |
| A | HIS109 |
| A | TRP224 |
| A | TYR228 |
| A | ARG231 |
| A | ARG327 |
| A | NAP350 |
| A | HOH2217 |
| site_id | AC5 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP B 350 |
| Chain | Residue |
| B | HOH2121 |
| B | HOH2122 |
| B | GLY11 |
| B | THR12 |
| B | MET13 |
| B | GLU14 |
| B | ARG18 |
| B | ASP40 |
| B | TYR45 |
| B | HIS109 |
| B | SER139 |
| B | ASN140 |
| B | GLN165 |
| B | TYR193 |
| B | ASN194 |
| B | PRO195 |
| B | LEU196 |
| B | ALA197 |
| B | GLY198 |
| B | GLY199 |
| B | LYS204 |
| B | TYR205 |
| B | ARG218 |
| B | TYR228 |
| B | THR260 |
| B | ILE282 |
| B | LEU283 |
| B | GLY284 |
| B | SER286 |
| B | GLN290 |
| B | GLN293 |
| B | ASN294 |
| B | ARG327 |
| B | TLA360 |
| B | HOH2070 |
| B | HOH2091 |
| B | HOH2120 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TLA B 360 |
| Chain | Residue |
| B | MET13 |
| B | MET44 |
| B | TYR45 |
| B | HIS109 |
| B | TRP224 |
| B | TYR228 |
| B | ARG231 |
| B | ARG327 |
| B | NAP350 |
| B | HOH2123 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MES B 364 |
| Chain | Residue |
| B | PRO76 |
| B | TRP77 |
| B | GLU78 |
| B | GLY79 |
| B | PRO111 |
| B | ASP112 |
| B | HIS113 |
| B | SER114 |
| F | PRO76 |
| F | TRP77 |
| F | GLU78 |
| F | HOH2054 |
| site_id | AC8 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP C 350 |
| Chain | Residue |
| C | GLY11 |
| C | THR12 |
| C | MET13 |
| C | ARG18 |
| C | ASP40 |
| C | TYR45 |
| C | HIS109 |
| C | SER139 |
| C | ASN140 |
| C | GLN165 |
| C | TYR193 |
| C | ASN194 |
| C | PRO195 |
| C | LEU196 |
| C | ALA197 |
| C | GLY198 |
| C | GLY199 |
| C | LYS204 |
| C | TYR205 |
| C | GLY217 |
| C | ARG218 |
| C | TYR228 |
| C | ILE282 |
| C | GLY284 |
| C | MET285 |
| C | SER286 |
| C | GLN290 |
| C | GLN293 |
| C | ASN294 |
| C | ARG327 |
| C | TLA360 |
| C | HOH2134 |
| C | HOH2214 |
| C | HOH2215 |
| C | HOH2216 |
| C | HOH2217 |
| C | HOH2218 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TLA C 360 |
| Chain | Residue |
| C | MET13 |
| C | MET44 |
| C | TYR45 |
| C | HIS109 |
| C | TRP224 |
| C | TYR228 |
| C | ARG231 |
| C | ARG327 |
| C | NAP350 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MES C 364 |
| Chain | Residue |
| C | TRP77 |
| C | GLU78 |
| C | GLY79 |
| H | TRP77 |
| H | GLU78 |
| H | GLY79 |
| H | PRO111 |
| H | ASP112 |
| H | HIS113 |
| site_id | BC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP D 350 |
| Chain | Residue |
| D | GLY11 |
| D | THR12 |
| D | MET13 |
| D | ARG18 |
| D | ASP40 |
| D | TYR45 |
| D | SER139 |
| D | ASN140 |
| D | GLN165 |
| D | TYR193 |
| D | ASN194 |
| D | PRO195 |
| D | LEU196 |
| D | ALA197 |
| D | GLY198 |
| D | GLY199 |
| D | THR202 |
| D | LYS204 |
| D | TYR205 |
| D | GLY217 |
| D | ARG218 |
| D | ILE282 |
| D | GLY284 |
| D | MET285 |
| D | SER286 |
| D | GLN290 |
| D | GLN293 |
| D | ASN294 |
| D | ARG327 |
| D | TLA360 |
| D | HOH2145 |
| D | HOH2155 |
| D | HOH2257 |
| D | HOH2258 |
| D | HOH2259 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TLA D 360 |
| Chain | Residue |
| D | MET13 |
| D | TYR45 |
| D | HIS109 |
| D | TRP224 |
| D | TYR228 |
| D | ARG231 |
| D | ARG327 |
| D | NAP350 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MES D 364 |
| Chain | Residue |
| D | PRO76 |
| D | TRP77 |
| D | GLU78 |
| D | GLY79 |
| D | PRO111 |
| D | HIS113 |
| D | HOH2273 |
| E | TRP77 |
| E | GLU78 |
| site_id | BC5 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NAP E 350 |
| Chain | Residue |
| E | GLY11 |
| E | THR12 |
| E | MET13 |
| E | ARG18 |
| E | ASP40 |
| E | TYR45 |
| E | SER139 |
| E | ASN140 |
| E | GLN165 |
| E | TYR193 |
| E | ASN194 |
| E | PRO195 |
| E | LEU196 |
| E | ALA197 |
| E | GLY198 |
| E | GLY199 |
| E | LYS204 |
| E | TYR205 |
| E | GLY217 |
| E | ARG218 |
| E | TYR228 |
| E | ILE282 |
| E | GLY284 |
| E | MET285 |
| E | SER286 |
| E | GLN290 |
| E | GLN293 |
| E | ASN294 |
| E | ARG327 |
| E | TLA360 |
| E | HOH2148 |
| E | HOH2160 |
| E | HOH2249 |
| E | HOH2250 |
| E | HOH2251 |
| E | HOH2252 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TLA E 360 |
| Chain | Residue |
| E | MET13 |
| E | TYR45 |
| E | HIS109 |
| E | TRP224 |
| E | TYR228 |
| E | ARG231 |
| E | ARG327 |
| E | NAP350 |
| site_id | BC7 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NAP F 350 |
| Chain | Residue |
| F | GLY11 |
| F | THR12 |
| F | MET13 |
| F | ASP40 |
| F | TYR45 |
| F | SER139 |
| F | ASN140 |
| F | GLN165 |
| F | TYR193 |
| F | ASN194 |
| F | PRO195 |
| F | LEU196 |
| F | ALA197 |
| F | GLY198 |
| F | GLY199 |
| F | THR202 |
| F | LYS204 |
| F | TYR205 |
| F | GLY217 |
| F | ARG218 |
| F | TYR228 |
| F | ILE282 |
| F | GLY284 |
| F | MET285 |
| F | SER286 |
| F | GLN290 |
| F | GLN293 |
| F | ASN294 |
| F | ARG327 |
| F | TLA360 |
| F | HOH2008 |
| F | HOH2128 |
| F | HOH2208 |
| F | HOH2209 |
| F | HOH2210 |
| F | HOH2211 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TLA F 360 |
| Chain | Residue |
| F | MET13 |
| F | TYR45 |
| F | HIS109 |
| F | TRP224 |
| F | TYR228 |
| F | ARG231 |
| F | ARG327 |
| F | NAP350 |
| site_id | BC9 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE NAP G 350 |
| Chain | Residue |
| G | GLY11 |
| G | THR12 |
| G | MET13 |
| G | ARG18 |
| G | ASP40 |
| G | TYR45 |
| G | SER139 |
| G | ASN140 |
| G | GLN165 |
| G | TYR193 |
| G | ASN194 |
| G | PRO195 |
| G | LEU196 |
| G | ALA197 |
| G | GLY198 |
| G | GLY199 |
| G | THR202 |
| G | LYS204 |
| G | TYR205 |
| G | GLY217 |
| G | ARG218 |
| G | TYR228 |
| G | THR260 |
| G | ILE282 |
| G | GLY284 |
| G | MET285 |
| G | SER286 |
| G | GLN290 |
| G | GLN293 |
| G | ASN294 |
| G | ARG327 |
| G | TLA360 |
| G | HOH2010 |
| G | HOH2124 |
| G | HOH2247 |
| G | HOH2248 |
| G | HOH2249 |
| G | HOH2250 |
| site_id | CC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TLA G 360 |
| Chain | Residue |
| G | MET13 |
| G | TYR45 |
| G | HIS109 |
| G | TRP224 |
| G | TYR228 |
| G | ARG231 |
| G | ARG327 |
| G | NAP350 |
| G | HOH2251 |
| site_id | CC2 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP H 350 |
| Chain | Residue |
| H | GLY11 |
| H | THR12 |
| H | MET13 |
| H | ASP40 |
| H | TYR45 |
| H | HIS109 |
| H | SER139 |
| H | ASN140 |
| H | GLN165 |
| H | TYR193 |
| H | ASN194 |
| H | PRO195 |
| H | LEU196 |
| H | ALA197 |
| H | GLY198 |
| H | GLY199 |
| H | LYS204 |
| H | TYR205 |
| H | GLY217 |
| H | ARG218 |
| H | TYR228 |
| H | ILE282 |
| H | LEU283 |
| H | GLY284 |
| H | SER286 |
| H | GLN290 |
| H | GLN293 |
| H | ASN294 |
| H | ARG327 |
| H | TLA360 |
| H | HOH2086 |
| H | HOH2147 |
| H | HOH2148 |
| H | HOH2149 |
| H | HOH2150 |
| H | HOH2151 |
| H | HOH2152 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TLA H 360 |
| Chain | Residue |
| H | MET13 |
| H | TYR45 |
| H | HIS109 |
| H | TRP224 |
| H | TYR228 |
| H | ARG231 |
| H | ARG327 |
| H | NAP350 |
| site_id | CC4 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP I 350 |
| Chain | Residue |
| I | GLY11 |
| I | THR12 |
| I | MET13 |
| I | ARG18 |
| I | ASP40 |
| I | TYR45 |
| I | SER139 |
| I | ASN140 |
| I | GLN165 |
| I | TYR193 |
| I | ASN194 |
| I | PRO195 |
| I | LEU196 |
| I | ALA197 |
| I | GLY198 |
| I | GLY199 |
| I | THR202 |
| I | LYS204 |
| I | TYR205 |
| I | GLY217 |
| I | ARG218 |
| I | TYR228 |
| I | ILE282 |
| I | LEU283 |
| I | GLY284 |
| I | MET285 |
| I | SER286 |
| I | GLN290 |
| I | GLN293 |
| I | ASN294 |
| I | ARG327 |
| I | TLA360 |
| I | HOH2109 |
| I | HOH2154 |
| I | HOH2155 |
| I | HOH2156 |
| I | HOH2157 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TLA I 360 |
| Chain | Residue |
| I | MET13 |
| I | TYR45 |
| I | HIS109 |
| I | TRP224 |
| I | TYR228 |
| I | ARG231 |
| I | ARG327 |
| I | NAP350 |
| site_id | CC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MES I 363 |
| Chain | Residue |
| A | GLU92 |
| A | THR93 |
| A | LYS96 |
| A | HOH2053 |
| I | GLN214 |
| I | PHE220 |
| I | GLY221 |
| I | ARG229 |
| I | HOH2118 |
| I | HOH2164 |
| site_id | CC7 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NAP J 350 |
| Chain | Residue |
| J | GLY11 |
| J | THR12 |
| J | MET13 |
| J | ARG18 |
| J | ASP40 |
| J | TYR45 |
| J | SER139 |
| J | ASN140 |
| J | GLN165 |
| J | TYR193 |
| J | ASN194 |
| J | PRO195 |
| J | LEU196 |
| J | ALA197 |
| J | GLY198 |
| J | GLY199 |
| J | LYS204 |
| J | TYR205 |
| J | GLY217 |
| J | ARG218 |
| J | TYR228 |
| J | ILE282 |
| J | GLY284 |
| J | MET285 |
| J | SER286 |
| J | GLN290 |
| J | GLN293 |
| J | ASN294 |
| J | ARG327 |
| J | TLA360 |
| J | HOH2003 |
| J | HOH2009 |
| J | HOH2122 |
| J | HOH2190 |
| J | HOH2191 |
| J | HOH2192 |
| site_id | CC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TLA J 360 |
| Chain | Residue |
| J | MET13 |
| J | TYR45 |
| J | HIS109 |
| J | TRP224 |
| J | TYR228 |
| J | ARG231 |
| J | ARG327 |
| J | NAP350 |
| J | HOH2193 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES J 368 |
| Chain | Residue |
| G | GLU92 |
| G | LYS96 |
| G | HOH2070 |
| J | GLN214 |
| J | PHE220 |
| J | GLY221 |
| J | ARG229 |
| J | HOH2140 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 361 |
| Chain | Residue |
| A | ARG231 |
| A | ASN324 |
| A | HOH2132 |
| A | HOH2218 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 363 |
| Chain | Residue |
| A | HIS113 |
| A | TRP144 |
| A | GLU145 |
| A | GLU148 |
| A | HOH2219 |
| A | HOH2220 |
| B | HIS185 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 361 |
| Chain | Residue |
| B | THR227 |
| B | ARG231 |
| B | ASN324 |
| B | PHE326 |
| B | ARG327 |
| B | HOH2124 |
| B | HOH2125 |
| B | HOH2126 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 362 |
| Chain | Residue |
| B | GLN214 |
| B | HOH2127 |
| F | LYS96 |
| site_id | DC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 363 |
| Chain | Residue |
| A | HIS185 |
| B | HIS113 |
| B | GLU145 |
| B | GLU148 |
| B | HOH2128 |
| B | HOH2129 |
| B | HOH2130 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 361 |
| Chain | Residue |
| C | THR227 |
| C | ARG231 |
| C | ASN324 |
| C | PHE326 |
| C | ARG327 |
| C | HOH2220 |
| site_id | DC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 362 |
| Chain | Residue |
| C | HIS113 |
| C | GLU145 |
| C | GLU148 |
| C | HOH2083 |
| C | HOH2221 |
| C | HOH2222 |
| C | HOH2223 |
| D | HIS185 |
| site_id | DC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 363 |
| Chain | Residue |
| C | GLN214 |
| C | PHE220 |
| C | GLY221 |
| C | ARG229 |
| C | HOH2224 |
| H | LYS96 |
| H | HOH2045 |
| site_id | DC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 361 |
| Chain | Residue |
| D | THR227 |
| D | ARG231 |
| D | ASN324 |
| D | PHE326 |
| D | ARG327 |
| D | HOH2261 |
| D | HOH2263 |
| D | HOH2264 |
| site_id | EC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL D 362 |
| Chain | Residue |
| C | HIS185 |
| D | HIS113 |
| D | TRP144 |
| D | GLU145 |
| D | GLU148 |
| D | HOH2100 |
| D | HOH2114 |
| D | HOH2265 |
| D | HOH2266 |
| D | HOH2267 |
| site_id | EC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 363 |
| Chain | Residue |
| D | GLN214 |
| D | HOH2268 |
| D | HOH2269 |
| D | HOH2270 |
| D | HOH2271 |
| E | GLU92 |
| E | LYS96 |
| site_id | EC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 361 |
| Chain | Residue |
| E | THR227 |
| E | ARG231 |
| E | ASN324 |
| E | PHE326 |
| E | ARG327 |
| E | HOH2254 |
| E | HOH2255 |
| site_id | EC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL E 362 |
| Chain | Residue |
| E | HIS113 |
| E | TRP144 |
| E | GLU145 |
| E | GLU148 |
| E | HOH2123 |
| E | HOH2256 |
| E | HOH2257 |
| E | HOH2258 |
| F | HIS185 |
| site_id | EC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL E 363 |
| Chain | Residue |
| E | HIS185 |
| E | HOH2259 |
| E | HOH2260 |
| E | HOH2261 |
| E | HOH2262 |
| F | HIS113 |
| F | GLU145 |
| F | GLU148 |
| site_id | EC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL F 361 |
| Chain | Residue |
| F | THR227 |
| F | ARG231 |
| F | ASN324 |
| F | PHE326 |
| F | ARG327 |
| F | HOH2213 |
| F | HOH2214 |
| site_id | EC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL G 362 |
| Chain | Residue |
| G | HIS113 |
| G | TRP144 |
| G | GLU145 |
| G | GLU148 |
| G | HOH2252 |
| G | HOH2253 |
| G | HOH2254 |
| H | HIS185 |
| site_id | EC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL G 363 |
| Chain | Residue |
| G | HIS185 |
| G | HOH2255 |
| G | HOH2256 |
| H | HIS113 |
| H | GLU145 |
| H | GLU148 |
| H | HOH2064 |
| site_id | EC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL G 364 |
| Chain | Residue |
| G | LYS80 |
| G | SER86 |
| G | GLN90 |
| G | HOH2065 |
| J | GLU226 |
| J | THR227 |
| J | ASN230 |
| J | HOH2142 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL H 361 |
| Chain | Residue |
| H | THR227 |
| H | ARG231 |
| H | ASN324 |
| H | PHE326 |
| H | ARG327 |
| H | HOH2154 |
| H | HOH2155 |
| site_id | FC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL H 362 |
| Chain | Residue |
| H | HOH2156 |
| H | HOH2157 |
| H | HOH2158 |
| H | HOH2159 |
| I | HIS113 |
| I | TRP144 |
| I | GLU145 |
| I | GLU148 |
| J | HIS185 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL I 361 |
| Chain | Residue |
| I | THR227 |
| I | ARG231 |
| I | ASN324 |
| I | ARG327 |
| I | HOH2159 |
| site_id | FC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL I 362 |
| Chain | Residue |
| I | HIS185 |
| I | HOH2160 |
| I | HOH2161 |
| I | HOH2162 |
| I | HOH2163 |
| J | HIS113 |
| J | GLU145 |
| J | GLU148 |
| J | HOH2097 |
| site_id | FC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL J 363 |
| Chain | Residue |
| G | THR227 |
| G | ARG231 |
| G | ASN324 |
| G | ARG327 |
| G | HOH2149 |
| J | HOH2195 |
| site_id | FC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL J 364 |
| Chain | Residue |
| J | THR227 |
| J | ARG231 |
| J | ASN324 |
| J | ARG327 |
| J | HOH2196 |
| J | HOH2197 |
| site_id | FC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL J 366 |
| Chain | Residue |
| G | GLU226 |
| G | ARG229 |
| J | SER89 |
| J | GLU92 |
| J | THR93 |
| J | HOH2198 |
| J | HOH2199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"16460003","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 260 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16460003","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"UniProtKB","id":"O43488","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| A | ASN75 | |
| A | TYR45 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| J | ASN75 | |
| J | TYR45 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| A | TYR45 | |
| A | LYS73 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| B | TYR45 | |
| B | LYS73 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| C | TYR45 | |
| C | LYS73 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| D | TYR45 | |
| D | LYS73 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| E | TYR45 | |
| E | LYS73 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| F | TYR45 | |
| F | LYS73 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| G | TYR45 | |
| G | LYS73 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| H | TYR45 | |
| H | LYS73 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| I | TYR45 | |
| I | LYS73 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| B | ASN75 | |
| B | TYR45 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| J | TYR45 | |
| J | LYS73 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| C | ASN75 | |
| C | TYR45 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| D | ASN75 | |
| D | TYR45 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| E | ASN75 | |
| E | TYR45 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| F | ASN75 | |
| F | TYR45 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| G | ASN75 | |
| G | TYR45 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| H | ASN75 | |
| H | TYR45 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2alr |
| Chain | Residue | Details |
| I | ASN75 | |
| I | TYR45 |
