2C82

X-Ray Structure Of 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase, DXR, Rv2870c, From Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0030145	molecular_function	manganese ion binding
A	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A	0046872	molecular_function	metal ion binding
A	0050897	molecular_function	cobalt ion binding
A	0051483	biological_process	terpenoid biosynthetic process, mevalonate-independent
A	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
A	0070402	molecular_function	NADPH binding
B	0000287	molecular_function	magnesium ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0030145	molecular_function	manganese ion binding
B	0030604	molecular_function	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B	0046872	molecular_function	metal ion binding
B	0050897	molecular_function	cobalt ion binding
B	0051483	biological_process	terpenoid biosynthetic process, mevalonate-independent
B	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
B	0070402	molecular_function	NADPH binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A1390

Chain	Residue
A	ALA176
A	SER177
A	SER213
A	ASN218
A	LYS219
A	HOH2167
A	HOH2168

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B1390

Chain	Residue
B	SER213
B	ASN218
B	LYS219
B	HOH2164
B	HOH2165
B	HOH2166
B	ALA176
B	SER177

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00183","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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