2C66
MAO inhibition by rasagiline analogues
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005740 | cellular_component | mitochondrial envelope |
A | 0005741 | cellular_component | mitochondrial outer membrane |
A | 0008131 | molecular_function | primary methylamine oxidase activity |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0021762 | biological_process | substantia nigra development |
A | 0042420 | biological_process | dopamine catabolic process |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
A | 0097621 | molecular_function | monoamine oxidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005740 | cellular_component | mitochondrial envelope |
B | 0005741 | cellular_component | mitochondrial outer membrane |
B | 0008131 | molecular_function | primary methylamine oxidase activity |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0021762 | biological_process | substantia nigra development |
B | 0042420 | biological_process | dopamine catabolic process |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0050665 | biological_process | hydrogen peroxide biosynthetic process |
B | 0097621 | molecular_function | monoamine oxidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD A1502 |
Chain | Residue |
A | VAL10 |
A | GLY40 |
A | GLY41 |
A | ARG42 |
A | THR43 |
A | GLY57 |
A | GLY58 |
A | SER59 |
A | TYR60 |
A | ARG233 |
A | PRO234 |
A | GLY11 |
A | VAL235 |
A | ALA263 |
A | TRP388 |
A | TYR393 |
A | CYS397 |
A | TYR398 |
A | GLY425 |
A | THR426 |
A | GLY434 |
A | TYR435 |
A | GLY13 |
A | MET436 |
A | ALA439 |
A | RM21503 |
A | HOH2001 |
A | HOH2003 |
A | HOH2050 |
A | HOH2083 |
A | HOH2084 |
A | HOH2085 |
A | ILE14 |
A | SER15 |
A | LEU33 |
A | GLU34 |
A | ALA35 |
A | ARG36 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE RM2 A1503 |
Chain | Residue |
A | LEU171 |
A | CYS172 |
A | ILE198 |
A | ILE199 |
A | GLN206 |
A | TYR326 |
A | TYR398 |
A | TYR435 |
A | FAD1502 |
A | HOH2086 |
site_id | AC3 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD B1497 |
Chain | Residue |
B | VAL10 |
B | GLY11 |
B | GLY13 |
B | ILE14 |
B | SER15 |
B | LEU33 |
B | GLU34 |
B | ALA35 |
B | ARG36 |
B | GLY41 |
B | ARG42 |
B | THR43 |
B | GLY57 |
B | GLY58 |
B | SER59 |
B | TYR60 |
B | ARG233 |
B | PRO234 |
B | VAL235 |
B | ALA263 |
B | TRP388 |
B | TYR393 |
B | CYS397 |
B | TYR398 |
B | GLY425 |
B | THR426 |
B | GLY434 |
B | TYR435 |
B | MET436 |
B | ALA439 |
B | RM21498 |
B | HOH2011 |
B | HOH2060 |
B | HOH2081 |
B | HOH2100 |
B | HOH2101 |
B | HOH2102 |
B | HOH2103 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE RM2 B1498 |
Chain | Residue |
B | LEU171 |
B | CYS172 |
B | ILE198 |
B | ILE199 |
B | GLN206 |
B | TYR326 |
B | TYR398 |
B | TYR435 |
B | FAD1497 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | Site: {"description":"Important for catalytic activity"} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BW75","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Modified residue: {"description":"S-8alpha-FAD cysteine","evidences":[{"source":"PubMed","id":"11753429","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12913124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15027868","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15710600","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16366596","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1OJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BYB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C64","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C70","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C75","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C76","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VZ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XFQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PO7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A7A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MRL","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1b5q |
Chain | Residue | Details |
A | GLY62 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1b5q |
Chain | Residue | Details |
B | GLY62 |