Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2C45

NATIVE PRECURSOR OF PYRUVOYL DEPENDENT ASPARTATE DECARBOXYLASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004068	molecular_function	aspartate 1-decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006523	biological_process	alanine biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0015940	biological_process	pantothenate biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
B	0004068	molecular_function	aspartate 1-decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006523	biological_process	alanine biosynthetic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0015940	biological_process	pantothenate biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
C	0004068	molecular_function	aspartate 1-decarboxylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006523	biological_process	alanine biosynthetic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0015940	biological_process	pantothenate biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
D	0004068	molecular_function	aspartate 1-decarboxylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006523	biological_process	alanine biosynthetic process
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0015940	biological_process	pantothenate biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
E	0004068	molecular_function	aspartate 1-decarboxylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006523	biological_process	alanine biosynthetic process
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0015940	biological_process	pantothenate biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
F	0004068	molecular_function	aspartate 1-decarboxylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006523	biological_process	alanine biosynthetic process
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0015940	biological_process	pantothenate biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
G	0004068	molecular_function	aspartate 1-decarboxylase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006523	biological_process	alanine biosynthetic process
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0015940	biological_process	pantothenate biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016831	molecular_function	carboxy-lyase activity
H	0004068	molecular_function	aspartate 1-decarboxylase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006523	biological_process	alanine biosynthetic process
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0015940	biological_process	pantothenate biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016831	molecular_function	carboxy-lyase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Schiff-base intermediate with substrate; via pyruvic acid","evidences":[{"source":"HAMAP-Rule","id":"MF_00446","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00446","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00446","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Pyruvic acid (Ser)","evidences":[{"source":"HAMAP-Rule","id":"MF_00446","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
F	TYR58

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
A	TYR58

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
E	TYR58

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
B	TYR58

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
H	TYR58

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
C	TYR58

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
D	TYR58

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1aw8

Chain	Residue	Details
G	TYR58

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)