2C3Q
Human glutathione-S-transferase T1-1 W234R mutant, complex with S- hexylglutathione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0004602 | molecular_function | glutathione peroxidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0004602 | molecular_function | glutathione peroxidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 402 |
| Chain | Residue |
| A | TRP115 |
| A | HIS176 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 408 |
| Chain | Residue |
| A | TRP101 |
| B | LYS53 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 401 |
| Chain | Residue |
| B | GLN12 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD B 402 |
| Chain | Residue |
| B | TRP115 |
| B | HIS176 |
| B | GTX301 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 404 |
| Chain | Residue |
| B | HIS103 |
| A | HIS103 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 405 |
| Chain | Residue |
| B | GLN183 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 406 |
| Chain | Residue |
| B | ALA156 |
| B | PRO161 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 407 |
| Chain | Residue |
| A | HOH2023 |
| B | TRP101 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 401 |
| Chain | Residue |
| C | ARG107 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 402 |
| Chain | Residue |
| C | TRP115 |
| C | HIS176 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 406 |
| Chain | Residue |
| C | ALA156 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 407 |
| Chain | Residue |
| C | TRP101 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 401 |
| Chain | Residue |
| D | ARG107 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 402 |
| Chain | Residue |
| D | TRP115 |
| D | HIS176 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 404 |
| Chain | Residue |
| D | GLN183 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD D 405 |
| Chain | Residue |
| C | HIS103 |
| C | HOH2047 |
| D | HIS103 |
| D | HOH2053 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 406 |
| Chain | Residue |
| D | ALA156 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 407 |
| Chain | Residue |
| D | TRP101 |
| site_id | CC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GTX A 301 |
| Chain | Residue |
| A | SER11 |
| A | LEU35 |
| A | HIS40 |
| A | LYS53 |
| A | VAL54 |
| A | PRO55 |
| A | GLU66 |
| A | SER67 |
| A | TRP115 |
| A | ARG234 |
| A | MET238 |
| A | HOH2026 |
| A | HOH2054 |
| A | HOH2109 |
| A | HOH2110 |
| B | HOH2048 |
| site_id | CC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTX B 301 |
| Chain | Residue |
| B | LEU35 |
| B | HIS40 |
| B | LYS53 |
| B | VAL54 |
| B | PRO55 |
| B | GLU66 |
| B | SER67 |
| B | ARG234 |
| B | MET238 |
| B | IOD402 |
| B | HOH2025 |
| B | HOH2092 |
| B | HOH2095 |
| B | HOH2096 |
| B | HOH2097 |
| site_id | CC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GTX C 301 |
| Chain | Residue |
| C | PRO13 |
| C | HIS40 |
| C | LYS53 |
| C | VAL54 |
| C | PRO55 |
| C | GLU66 |
| C | SER67 |
| C | ARG234 |
| C | MET238 |
| C | HOH2051 |
| C | HOH2090 |
| C | HOH2093 |
| C | HOH2094 |
| site_id | CC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTX D 301 |
| Chain | Residue |
| C | HOH2052 |
| D | SER11 |
| D | HIS40 |
| D | LYS53 |
| D | VAL54 |
| D | PRO55 |
| D | GLU66 |
| D | SER67 |
| D | ARG234 |
| D | MET238 |
| D | HOH2027 |
| D | HOH2032 |
| D | HOH2106 |
| D | HOH2107 |
| D | HOH2108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:16298388 |
| Chain | Residue | Details |
| A | LEU41 | |
| D | LEU41 | |
| D | VAL54 | |
| D | SER67 | |
| A | VAL54 | |
| A | SER67 | |
| B | LEU41 | |
| B | VAL54 | |
| B | SER67 | |
| C | LEU41 | |
| C | VAL54 | |
| C | SER67 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | LEU7 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | LEU7 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| C | LEU7 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| D | LEU7 |
