2C2W
The fluorinase from Streptomyces cattleya is also a chlorinase. Structure of 5'-chloro-5'-deoxyadenosine crystallised in the fluorinase.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
| A | 0033846 | molecular_function | adenosyl-fluoride synthase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0033846 | molecular_function | adenosyl-fluoride synthase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0033846 | molecular_function | adenosyl-fluoride synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A1299 |
| Chain | Residue |
| A | HIS287 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A1300 |
| Chain | Residue |
| A | ASN268 |
| A | SER269 |
| A | HOH2156 |
| C | THR155 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A1301 |
| Chain | Residue |
| A | PHE110 |
| A | ARG112 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B1299 |
| Chain | Residue |
| B | TRP217 |
| B | TYR266 |
| B | HOH2144 |
| B | HOH2177 |
| B | ASP210 |
| B | ASN215 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B1300 |
| Chain | Residue |
| B | HIS287 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C1299 |
| Chain | Residue |
| C | THR82 |
| C | TYR157 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL C1300 |
| Chain | Residue |
| C | GLU133 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 5CD A 500 |
| Chain | Residue |
| A | ASP16 |
| A | LEU17 |
| A | TRP50 |
| A | TYR77 |
| A | PRO78 |
| A | THR80 |
| A | THR155 |
| A | PHE156 |
| A | SER158 |
| B | PHE213 |
| B | ASN215 |
| B | PHE254 |
| B | ARG277 |
| B | ALA279 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 5CD B 500 |
| Chain | Residue |
| B | ASP16 |
| B | LEU17 |
| B | TRP50 |
| B | TYR77 |
| B | PRO78 |
| B | THR80 |
| B | THR155 |
| B | PHE156 |
| B | SER158 |
| C | PHE213 |
| C | ASN215 |
| C | PHE254 |
| C | ARG277 |
| C | ALA279 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 5CD C 500 |
| Chain | Residue |
| A | PHE213 |
| A | ASN215 |
| A | PHE254 |
| A | ARG277 |
| A | ALA279 |
| C | ASP16 |
| C | LEU17 |
| C | TRP50 |
| C | THR76 |
| C | TYR77 |
| C | PRO78 |
| C | THR80 |
| C | THR155 |
| C | PHE156 |
| C | SER158 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14765200","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16370017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16604208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17985882","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2005","submissionDatabase":"PDB data bank","title":"Substrates and inhibitors of the fluorinase from Streptomyces cattleya.","authors":["Mcewan A.R.","Deng H.","Mcglinchey R.P.","Robinson D.R.","O'Hagan D.","Naismith J.H."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2014","submissionDatabase":"PDB data bank","title":"Structure of a bacterial fluorinating enzyme with.","authors":["Thomson S.","Mcmahon S.A.","Naismith J.H.","O'Hagan D."]}}]} |
| Chain | Residue | Details |
