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2C2L

Crystal structure of the CHIP U-box E3 ubiquitin ligase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000151cellular_componentubiquitin ligase complex
A0000165biological_processMAPK cascade
A0000209biological_processprotein polyubiquitination
A0001664molecular_functionG protein-coupled receptor binding
A0002931biological_processresponse to ischemia
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006457biological_processprotein folding
A0006511biological_processubiquitin-dependent protein catabolic process
A0006513biological_processprotein monoubiquitination
A0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0030018cellular_componentZ disc
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030544molecular_functionHsp70 protein binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030911molecular_functionTPR domain binding
A0030968biological_processendoplasmic reticulum unfolded protein response
A0031072molecular_functionheat shock protein binding
A0031371cellular_componentubiquitin conjugating enzyme complex
A0031398biological_processpositive regulation of protein ubiquitination
A0031625molecular_functionubiquitin protein ligase binding
A0031647biological_processregulation of protein stability
A0031943biological_processregulation of glucocorticoid metabolic process
A0032091biological_processnegative regulation of protein binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0034392biological_processnegative regulation of smooth muscle cell apoptotic process
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0034450molecular_functionubiquitin-ubiquitin ligase activity
A0034605biological_processcellular response to heat
A0035359biological_processnegative regulation of peroxisome proliferator activated receptor signaling pathway
A0036503biological_processERAD pathway
A0042405cellular_componentnuclear inclusion body
A0042803molecular_functionprotein homodimerization activity
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045862biological_processpositive regulation of proteolysis
A0046332molecular_functionSMAD binding
A0050821biological_processprotein stabilization
A0051087molecular_functionprotein-folding chaperone binding
A0051443biological_processpositive regulation of ubiquitin-protein transferase activity
A0051604biological_processprotein maturation
A0051787molecular_functionmisfolded protein binding
A0051865biological_processprotein autoubiquitination
A0051879molecular_functionHsp90 protein binding
A0061630molecular_functionubiquitin protein ligase activity
A0061684biological_processchaperone-mediated autophagy
A0070412molecular_functionR-SMAD binding
A0070534biological_processprotein K63-linked ubiquitination
A0071218biological_processcellular response to misfolded protein
A0071456biological_processcellular response to hypoxia
A0090035biological_processpositive regulation of chaperone-mediated protein complex assembly
A0101031cellular_componentprotein folding chaperone complex
A1901526biological_processpositive regulation of mitophagy
A1904294biological_processpositive regulation of ERAD pathway
B0000151cellular_componentubiquitin ligase complex
B0000165biological_processMAPK cascade
B0000209biological_processprotein polyubiquitination
B0001664molecular_functionG protein-coupled receptor binding
B0002931biological_processresponse to ischemia
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006457biological_processprotein folding
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019899molecular_functionenzyme binding
B0019900molecular_functionkinase binding
B0030018cellular_componentZ disc
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0030544molecular_functionHsp70 protein binding
B0030674molecular_functionprotein-macromolecule adaptor activity
B0030911molecular_functionTPR domain binding
B0030968biological_processendoplasmic reticulum unfolded protein response
B0031072molecular_functionheat shock protein binding
B0031371cellular_componentubiquitin conjugating enzyme complex
B0031398biological_processpositive regulation of protein ubiquitination
B0031625molecular_functionubiquitin protein ligase binding
B0031647biological_processregulation of protein stability
B0031943biological_processregulation of glucocorticoid metabolic process
B0032091biological_processnegative regulation of protein binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0034392biological_processnegative regulation of smooth muscle cell apoptotic process
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0034605biological_processcellular response to heat
B0035359biological_processnegative regulation of peroxisome proliferator activated receptor signaling pathway
B0036503biological_processERAD pathway
B0042405cellular_componentnuclear inclusion body
B0042803molecular_functionprotein homodimerization activity
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045862biological_processpositive regulation of proteolysis
B0046332molecular_functionSMAD binding
B0050821biological_processprotein stabilization
B0051087molecular_functionprotein-folding chaperone binding
B0051443biological_processpositive regulation of ubiquitin-protein transferase activity
B0051604biological_processprotein maturation
B0051787molecular_functionmisfolded protein binding
B0051865biological_processprotein autoubiquitination
B0051879molecular_functionHsp90 protein binding
B0061630molecular_functionubiquitin protein ligase activity
B0061684biological_processchaperone-mediated autophagy
B0070412molecular_functionR-SMAD binding
B0070534biological_processprotein K63-linked ubiquitination
B0071218biological_processcellular response to misfolded protein
B0071456biological_processcellular response to hypoxia
B0090035biological_processpositive regulation of chaperone-mediated protein complex assembly
B0101031cellular_componentprotein folding chaperone complex
B1901526biological_processpositive regulation of mitophagy
B1904294biological_processpositive regulation of ERAD pathway
C0000151cellular_componentubiquitin ligase complex
C0000165biological_processMAPK cascade
C0000209biological_processprotein polyubiquitination
C0001664molecular_functionG protein-coupled receptor binding
C0002931biological_processresponse to ischemia
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006457biological_processprotein folding
C0006511biological_processubiquitin-dependent protein catabolic process
C0006513biological_processprotein monoubiquitination
C0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
C0016567biological_processprotein ubiquitination
C0016740molecular_functiontransferase activity
C0019899molecular_functionenzyme binding
C0019900molecular_functionkinase binding
C0030018cellular_componentZ disc
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0030544molecular_functionHsp70 protein binding
C0030674molecular_functionprotein-macromolecule adaptor activity
C0030911molecular_functionTPR domain binding
C0030968biological_processendoplasmic reticulum unfolded protein response
C0031072molecular_functionheat shock protein binding
C0031371cellular_componentubiquitin conjugating enzyme complex
C0031398biological_processpositive regulation of protein ubiquitination
C0031625molecular_functionubiquitin protein ligase binding
C0031647biological_processregulation of protein stability
C0031943biological_processregulation of glucocorticoid metabolic process
C0032091biological_processnegative regulation of protein binding
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0034392biological_processnegative regulation of smooth muscle cell apoptotic process
C0034393biological_processpositive regulation of smooth muscle cell apoptotic process
C0034450molecular_functionubiquitin-ubiquitin ligase activity
C0034605biological_processcellular response to heat
C0035359biological_processnegative regulation of peroxisome proliferator activated receptor signaling pathway
C0036503biological_processERAD pathway
C0042405cellular_componentnuclear inclusion body
C0042803molecular_functionprotein homodimerization activity
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0045862biological_processpositive regulation of proteolysis
C0046332molecular_functionSMAD binding
C0050821biological_processprotein stabilization
C0051087molecular_functionprotein-folding chaperone binding
C0051443biological_processpositive regulation of ubiquitin-protein transferase activity
C0051604biological_processprotein maturation
C0051787molecular_functionmisfolded protein binding
C0051865biological_processprotein autoubiquitination
C0051879molecular_functionHsp90 protein binding
C0061630molecular_functionubiquitin protein ligase activity
C0061684biological_processchaperone-mediated autophagy
C0070412molecular_functionR-SMAD binding
C0070534biological_processprotein K63-linked ubiquitination
C0071218biological_processcellular response to misfolded protein
C0071456biological_processcellular response to hypoxia
C0090035biological_processpositive regulation of chaperone-mediated protein complex assembly
C0101031cellular_componentprotein folding chaperone complex
C1901526biological_processpositive regulation of mitophagy
C1904294biological_processpositive regulation of ERAD pathway
D0000151cellular_componentubiquitin ligase complex
D0000165biological_processMAPK cascade
D0000209biological_processprotein polyubiquitination
D0001664molecular_functionG protein-coupled receptor binding
D0002931biological_processresponse to ischemia
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006457biological_processprotein folding
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0006515biological_processprotein quality control for misfolded or incompletely synthesized proteins
D0016567biological_processprotein ubiquitination
D0016740molecular_functiontransferase activity
D0019899molecular_functionenzyme binding
D0019900molecular_functionkinase binding
D0030018cellular_componentZ disc
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0030544molecular_functionHsp70 protein binding
D0030674molecular_functionprotein-macromolecule adaptor activity
D0030911molecular_functionTPR domain binding
D0030968biological_processendoplasmic reticulum unfolded protein response
D0031072molecular_functionheat shock protein binding
D0031371cellular_componentubiquitin conjugating enzyme complex
D0031398biological_processpositive regulation of protein ubiquitination
D0031625molecular_functionubiquitin protein ligase binding
D0031647biological_processregulation of protein stability
D0031943biological_processregulation of glucocorticoid metabolic process
D0032091biological_processnegative regulation of protein binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0034392biological_processnegative regulation of smooth muscle cell apoptotic process
D0034393biological_processpositive regulation of smooth muscle cell apoptotic process
D0034450molecular_functionubiquitin-ubiquitin ligase activity
D0034605biological_processcellular response to heat
D0035359biological_processnegative regulation of peroxisome proliferator activated receptor signaling pathway
D0036503biological_processERAD pathway
D0042405cellular_componentnuclear inclusion body
D0042803molecular_functionprotein homodimerization activity
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0045862biological_processpositive regulation of proteolysis
D0046332molecular_functionSMAD binding
D0050821biological_processprotein stabilization
D0051087molecular_functionprotein-folding chaperone binding
D0051443biological_processpositive regulation of ubiquitin-protein transferase activity
D0051604biological_processprotein maturation
D0051787molecular_functionmisfolded protein binding
D0051865biological_processprotein autoubiquitination
D0051879molecular_functionHsp90 protein binding
D0061630molecular_functionubiquitin protein ligase activity
D0061684biological_processchaperone-mediated autophagy
D0070412molecular_functionR-SMAD binding
D0070534biological_processprotein K63-linked ubiquitination
D0071218biological_processcellular response to misfolded protein
D0071456biological_processcellular response to hypoxia
D0090035biological_processpositive regulation of chaperone-mediated protein complex assembly
D0101031cellular_componentprotein folding chaperone complex
D1901526biological_processpositive regulation of mitophagy
D1904294biological_processpositive regulation of ERAD pathway
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1305
ChainResidue
ASER26
AALA27
AARG56
AASN57
DSER26
DALA27
DARG56
DASN57

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1306
ChainResidue
AGLN105
AASN117
AARG85

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1307
ChainResidue
AGLN33
AARG36
CLEU285
DLYS235

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 1305
ChainResidue
BSER26
BALA27
BARG56
BASN57
CALA27
CARG56
CASN57

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1306
ChainResidue
BARG85
BGLN105
BGLU113
BARG120

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 C 1305
ChainResidue
CARG85
CGLN105
CASN117

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 1305
ChainResidue
DARG85
DGLN105
DGLU113
DASN117

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER24
BSER24
CSER24
DSER24

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19131326
ChainResidueDetails
ASER26
BSER26
CSER26
DSER26

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UNE7
ChainResidueDetails
ASER150
ASER274
BSER150
BSER274
CSER150
CSER274
DSER150
DSER274

site_idSWS_FT_FI4
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9UNE7
ChainResidueDetails
ALYS222
DLYS222
DLYS256
ALYS256
BLYS222
BLYS256
CLYS222
CLYS256

226707

PDB entries from 2024-10-30

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