2C2H
CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007163 | biological_process | establishment or maintenance of cell polarity |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0008045 | biological_process | motor neuron axon guidance |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0014041 | biological_process | regulation of neuron maturation |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016601 | biological_process | Rac protein signal transduction |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0021894 | biological_process | cerebral cortex GABAergic interneuron development |
| A | 0022604 | biological_process | regulation of cell morphogenesis |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030031 | biological_process | cell projection assembly |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030426 | cellular_component | growth cone |
| A | 0030865 | biological_process | cortical cytoskeleton organization |
| A | 0031175 | biological_process | neuron projection development |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031941 | cellular_component | filamentous actin |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0033630 | biological_process | positive regulation of cell adhesion mediated by integrin |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043020 | cellular_component | NADPH oxidase complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043652 | biological_process | engulfment of apoptotic cell |
| A | 0045730 | biological_process | respiratory burst |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0048873 | biological_process | homeostasis of number of cells within a tissue |
| A | 0050885 | biological_process | neuromuscular process controlling balance |
| A | 0050905 | biological_process | neuromuscular process |
| A | 0051932 | biological_process | synaptic transmission, GABAergic |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071944 | cellular_component | cell periphery |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098974 | biological_process | postsynaptic actin cytoskeleton organization |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0150052 | biological_process | regulation of postsynapse assembly |
| A | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| A | 1902622 | biological_process | regulation of neutrophil migration |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007015 | biological_process | actin filament organization |
| B | 0007163 | biological_process | establishment or maintenance of cell polarity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0008045 | biological_process | motor neuron axon guidance |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0012505 | cellular_component | endomembrane system |
| B | 0014041 | biological_process | regulation of neuron maturation |
| B | 0016055 | biological_process | Wnt signaling pathway |
| B | 0016601 | biological_process | Rac protein signal transduction |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0021894 | biological_process | cerebral cortex GABAergic interneuron development |
| B | 0022604 | biological_process | regulation of cell morphogenesis |
| B | 0030027 | cellular_component | lamellipodium |
| B | 0030031 | biological_process | cell projection assembly |
| B | 0030036 | biological_process | actin cytoskeleton organization |
| B | 0030426 | cellular_component | growth cone |
| B | 0030865 | biological_process | cortical cytoskeleton organization |
| B | 0031175 | biological_process | neuron projection development |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031941 | cellular_component | filamentous actin |
| B | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| B | 0033630 | biological_process | positive regulation of cell adhesion mediated by integrin |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043020 | cellular_component | NADPH oxidase complex |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043652 | biological_process | engulfment of apoptotic cell |
| B | 0045730 | biological_process | respiratory burst |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0048873 | biological_process | homeostasis of number of cells within a tissue |
| B | 0050885 | biological_process | neuromuscular process controlling balance |
| B | 0050905 | biological_process | neuromuscular process |
| B | 0051932 | biological_process | synaptic transmission, GABAergic |
| B | 0060326 | biological_process | cell chemotaxis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071944 | cellular_component | cell periphery |
| B | 0098794 | cellular_component | postsynapse |
| B | 0098974 | biological_process | postsynaptic actin cytoskeleton organization |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0150052 | biological_process | regulation of postsynapse assembly |
| B | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| B | 1902622 | biological_process | regulation of neutrophil migration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A1183 |
| Chain | Residue |
| A | HIS104 |
| A | GDP1179 |
| A | GDP1180 |
| A | HOH2050 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A1184 |
| Chain | Residue |
| A | HIS103 |
| A | GDP1179 |
| A | GDP1180 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A1185 |
| Chain | Residue |
| A | SO41189 |
| A | HOH2099 |
| A | GDP1180 |
| A | GDP1181 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A1186 |
| Chain | Residue |
| A | HIS107 |
| A | GDP1181 |
| A | SO41188 |
| A | SO41189 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A1187 |
| Chain | Residue |
| A | GDP1181 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A1188 |
| Chain | Residue |
| A | PRO106 |
| A | HIS107 |
| A | GDP1180 |
| A | GDP1181 |
| A | CA1186 |
| A | SO41189 |
| A | CA1193 |
| A | HOH2048 |
| A | HOH2099 |
| A | HOH2102 |
| A | HOH2103 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A1189 |
| Chain | Residue |
| A | HIS107 |
| A | GDP1181 |
| A | CA1185 |
| A | CA1186 |
| A | SO41188 |
| A | CA1193 |
| A | HOH2099 |
| A | HOH2104 |
| A | HOH2105 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A1190 |
| Chain | Residue |
| A | THR17 |
| A | GDP1178 |
| A | HOH2008 |
| A | HOH2019 |
| A | HOH2081 |
| A | HOH2082 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A1191 |
| Chain | Residue |
| A | GDP1179 |
| A | GDP1180 |
| A | HOH2086 |
| A | HOH2089 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A1192 |
| Chain | Residue |
| A | GDP1180 |
| A | HOH2001 |
| A | HOH2085 |
| A | HOH2087 |
| A | HOH2094 |
| A | HOH2102 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA A1193 |
| Chain | Residue |
| A | SO41188 |
| A | SO41189 |
| A | HOH2103 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B1182 |
| Chain | Residue |
| B | HIS107 |
| B | GDP1181 |
| B | SO41187 |
| B | SO41188 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B1183 |
| Chain | Residue |
| B | GDP1181 |
| B | SO41187 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B1184 |
| Chain | Residue |
| B | HIS104 |
| B | GDP1179 |
| B | GDP1180 |
| B | HOH2049 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B1185 |
| Chain | Residue |
| B | HIS103 |
| B | GDP1179 |
| B | GDP1180 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA B1186 |
| Chain | Residue |
| B | GDP1181 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1187 |
| Chain | Residue |
| B | HIS107 |
| B | GDP1181 |
| B | CA1182 |
| B | CA1183 |
| B | SO41188 |
| B | CA1191 |
| B | HOH2059 |
| B | HOH2060 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B1188 |
| Chain | Residue |
| B | PRO106 |
| B | HIS107 |
| B | GDP1180 |
| B | GDP1181 |
| B | CA1182 |
| B | SO41187 |
| B | CA1191 |
| B | HOH2061 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B1189 |
| Chain | Residue |
| B | THR17 |
| B | GDP1178 |
| B | HOH2005 |
| B | HOH2013 |
| B | HOH2044 |
| B | HOH2045 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B1190 |
| Chain | Residue |
| B | GDP1179 |
| B | GDP1180 |
| B | HOH2046 |
| B | HOH2048 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B1191 |
| Chain | Residue |
| B | SO41187 |
| B | SO41188 |
| B | HOH2061 |
| site_id | CC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GDP A1178 |
| Chain | Residue |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | CYS18 |
| A | PHE28 |
| A | LYS116 |
| A | ASP118 |
| A | LEU119 |
| A | ARG147 |
| A | SER158 |
| A | ALA159 |
| A | LEU160 |
| A | MG1190 |
| A | HOH2007 |
| A | HOH2080 |
| A | HOH2081 |
| A | HOH2082 |
| A | HOH2083 |
| A | HOH2084 |
| A | ALA13 |
| site_id | CC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GDP A1179 |
| Chain | Residue |
| A | PRO99 |
| A | GLU100 |
| A | HIS103 |
| A | HIS104 |
| A | GDP1180 |
| A | GDP1181 |
| A | CA1183 |
| A | CA1184 |
| A | MG1191 |
| A | HOH2085 |
| A | HOH2086 |
| A | HOH2087 |
| A | HOH2089 |
| site_id | CC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GDP A1180 |
| Chain | Residue |
| A | HIS103 |
| A | HIS104 |
| A | PRO106 |
| A | GDP1179 |
| A | GDP1181 |
| A | CA1183 |
| A | CA1184 |
| A | CA1185 |
| A | SO41188 |
| A | MG1191 |
| A | MG1192 |
| A | HOH2085 |
| A | HOH2086 |
| A | HOH2087 |
| A | HOH2088 |
| A | HOH2089 |
| A | HOH2090 |
| A | HOH2091 |
| A | HOH2092 |
| site_id | CC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GDP A1181 |
| Chain | Residue |
| A | HIS107 |
| A | GDP1179 |
| A | GDP1180 |
| A | CA1185 |
| A | CA1186 |
| A | CA1187 |
| A | SO41188 |
| A | SO41189 |
| A | HOH2052 |
| A | HOH2085 |
| A | HOH2095 |
| A | HOH2096 |
| A | HOH2098 |
| A | HOH2099 |
| A | HOH2105 |
| site_id | CC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GDP A1182 |
| Chain | Residue |
| A | ALA27 |
| A | PHE28 |
| A | GLY30 |
| A | LEU117 |
| A | ARG120 |
| A | TYR139 |
| A | GLU156 |
| A | ARG163 |
| A | HOH2071 |
| A | HOH2100 |
| A | HOH2101 |
| B | ASP170 |
| site_id | CC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GDP B1178 |
| Chain | Residue |
| B | ALA13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| B | CYS18 |
| B | PHE28 |
| B | LYS116 |
| B | ASP118 |
| B | LEU119 |
| B | SER158 |
| B | ALA159 |
| B | LEU160 |
| B | MG1189 |
| B | HOH2003 |
| B | HOH2013 |
| B | HOH2044 |
| B | HOH2045 |
| site_id | DC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GDP B1179 |
| Chain | Residue |
| B | PRO99 |
| B | GLU100 |
| B | HIS103 |
| B | HIS104 |
| B | GDP1180 |
| B | GDP1181 |
| B | CA1184 |
| B | CA1185 |
| B | MG1190 |
| B | HOH2046 |
| B | HOH2047 |
| B | HOH2048 |
| site_id | DC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDP B1180 |
| Chain | Residue |
| B | HIS103 |
| B | HIS104 |
| B | PRO106 |
| B | GDP1179 |
| B | GDP1181 |
| B | CA1184 |
| B | CA1185 |
| B | SO41188 |
| B | MG1190 |
| B | HOH2046 |
| B | HOH2048 |
| B | HOH2049 |
| B | HOH2050 |
| B | HOH2051 |
| B | HOH2052 |
| B | HOH2054 |
| B | HOH2055 |
| site_id | DC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GDP B1181 |
| Chain | Residue |
| B | HIS107 |
| B | GDP1179 |
| B | GDP1180 |
| B | CA1182 |
| B | CA1183 |
| B | CA1186 |
| B | SO41187 |
| B | SO41188 |
| B | HOH2029 |
| B | HOH2051 |
| B | HOH2055 |
| B | HOH2056 |
| B | HOH2057 |
| B | HOH2058 |
| B | HOH2059 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY10 | |
| A | ASP57 | |
| A | THR115 | |
| B | GLY10 | |
| B | ASP57 | |
| B | THR115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Cysteine methyl ester => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS189 | |
| B | CYS189 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: S-geranylgeranyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS189 | |
| B | CYS189 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 |
| Chain | Residue | Details |
| A | TYR32 | |
| B | TYR32 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24684802 |
| Chain | Residue | Details |
| A | LYS166 | |
| B | LYS166 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN61 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN61 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | ALA13 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | ALA13 |
