2C1G

Structure of Streptococcus pneumoniae peptidoglycan deacetylase (SpPgdA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0042545	biological_process	cell wall modification
A	0046872	molecular_function	metal ion binding
A	0050119	molecular_function	N-acetylglucosamine deacetylase activity
A	0060241	molecular_function	lysozyme inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ACT A1464

Chain	Residue
A	ASP275
A	PEG1468
A	HOH2176
A	ASP276
A	HIS326
A	HIS330
A	PRO366
A	TYR367
A	TRP385
A	HIS417
A	ZN1465

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A1465

Chain	Residue
A	ASP276
A	HIS326
A	HIS330
A	ACT1464
A	HOH2176

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1466

Chain	Residue
A	GLU144
A	GLU146
A	GLU340
A	HOH2177

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A1467

Chain	Residue
A	ASP379
A	HIS455

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A1468

Chain	Residue
A	TYR367
A	TRP392
A	ACT1464

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	174
Details	Domain: {"description":"NodB homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU01014","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16221761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"16221761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16221761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Raises pKa of active site His","evidences":[{"source":"PubMed","id":"16221761","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---