2C0Y

THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001968	molecular_function	fibronectin binding
A	0002224	biological_process	toll-like receptor signaling pathway
A	0002250	biological_process	adaptive immune response
A	0002577	biological_process	regulation of antigen processing and presentation
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005518	molecular_function	collagen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0005770	cellular_component	late endosome
A	0006508	biological_process	proteolysis
A	0006955	biological_process	immune response
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0010447	biological_process	response to acidic pH
A	0016485	biological_process	protein processing
A	0016787	molecular_function	hydrolase activity
A	0019882	biological_process	antigen processing and presentation
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0022617	biological_process	extracellular matrix disassembly
A	0030574	biological_process	collagen catabolic process
A	0031012	cellular_component	extracellular matrix
A	0031410	cellular_component	cytoplasmic vesicle
A	0034769	biological_process	basement membrane disassembly
A	0036021	cellular_component	endolysosome lumen
A	0043202	cellular_component	lysosomal lumen
A	0043236	molecular_function	laminin binding
A	0043394	molecular_function	proteoglycan binding
A	0045335	cellular_component	phagocytic vesicle
A	0048002	biological_process	antigen processing and presentation of peptide antigen
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0097067	biological_process	cellular response to thyroid hormone stimulus
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001259	biological_process	positive regulation of cation channel activity

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHGVLVVGYG

Chain	Residue	Details
A	VAL261-GLY271

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site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWghnFGeeGYIrM

Chain	Residue	Details
A	TYR278-MET297

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	ALA124
A	HIS263
A	ASN283

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9524075

Chain	Residue	Details
A	ASN89

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 9pap

Chain	Residue	Details
A	GLN118
A	ASN283
A	HIS263

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 9pap

Chain	Residue	Details
A	GLN118
A	HIS263
A	ASN283
A	ALA124

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 814

Chain	Residue	Details
A	GLN118	electrostatic stabiliser
A	ALA124	nucleofuge, nucleophile, proton acceptor, proton donor
A	HIS263	proton acceptor, proton donor
A	ASN283	electrostatic stabiliser

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