2C0Y
THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001968 | molecular_function | fibronectin binding |
| A | 0002224 | biological_process | toll-like receptor signaling pathway |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002577 | biological_process | regulation of antigen processing and presentation |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005764 | cellular_component | lysosome |
| A | 0005770 | cellular_component | late endosome |
| A | 0006508 | biological_process | proteolysis |
| A | 0006955 | biological_process | immune response |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0010447 | biological_process | response to acidic pH |
| A | 0016485 | biological_process | protein processing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030574 | biological_process | collagen catabolic process |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0034769 | biological_process | basement membrane disassembly |
| A | 0036021 | cellular_component | endolysosome lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043236 | molecular_function | laminin binding |
| A | 0043394 | molecular_function | proteoglycan binding |
| A | 0045335 | cellular_component | phagocytic vesicle |
| A | 0048002 | biological_process | antigen processing and presentation of peptide antigen |
| A | 0051603 | biological_process | obsolete proteolysis involved in protein catabolic process |
| A | 0097067 | biological_process | cellular response to thyroid hormone stimulus |
| A | 1904724 | cellular_component | tertiary granule lumen |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| A | 2001259 | biological_process | positive regulation of cation channel activity |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHGVLVVGYG |
| Chain | Residue | Details |
| A | VAL261-GLY271 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWghnFGeeGYIrM |
| Chain | Residue | Details |
| A | TYR278-MET297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"9524075","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| A | GLN118 | |
| A | ASN283 | |
| A | HIS263 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| A | GLN118 | |
| A | HIS263 | |
| A | ASN283 | |
| A | ALA124 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 814 |
| Chain | Residue | Details |
| A | GLN118 | electrostatic stabiliser |
| A | ALA124 | nucleofuge, nucleophile, proton acceptor, proton donor |
| A | HIS263 | proton acceptor, proton donor |
| A | ASN283 | electrostatic stabiliser |
