2BZZ

Crystal Structures of Eosinophil-derived Neurotoxin in Complex with the Inhibitors 5'-ATP, Ap3A, Ap4A and Ap5A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE AP5 A2135

Chain	Residue
A	GLN1014
A	ALA1110
A	ASP1112
A	VAL1128
A	HIS1129
A	LEU1130
A	HOH2058
A	HOH2065
A	HOH2066
A	HOH2165
A	HOH2172
A	HIS1015
A	HOH2173
A	HOH2174
A	HOH2175
A	HOH2176
A	HOH2177
A	HOH2178
A	ARG1036
A	LYS1038
A	GLN1040
A	CYS1062
A	ARG1068
A	ASN1070
A	HIS1082

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACY A2136

Chain	Residue
A	THR1046
A	ASN1050
A	SER1074
A	SER1076
A	VAL1078
A	TYR1107
A	HOH2180
A	HOH2181

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Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF

Chain	Residue	Details
A	CYS1037-PHE1043

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	HIS1015

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	HIS1129

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS1038

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:18694936

Chain	Residue	Details
A	TYR1033

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:7947762, ECO:0000269|PubMed:9450956

Chain	Residue	Details
A	TRP1007

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site_id	SWS_FT_FI6
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
A	ASN1017
A	ASN1059
A	ASN1065
A	ASN1084
A	ASN1092

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4y

Chain	Residue	Details
A	LYS1038
A	HIS1129
A	HIS1015

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