Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BZN

Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003920	molecular_function	GMP reductase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006144	biological_process	purine nucleobase metabolic process
A	0006163	biological_process	purine nucleotide metabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046037	biological_process	GMP metabolic process
A	0046872	molecular_function	metal ion binding
A	1902560	cellular_component	GMP reductase complex
B	0003824	molecular_function	catalytic activity
B	0003920	molecular_function	GMP reductase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006144	biological_process	purine nucleobase metabolic process
B	0006163	biological_process	purine nucleotide metabolic process
B	0009117	biological_process	nucleotide metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0046037	biological_process	GMP metabolic process
B	0046872	molecular_function	metal ion binding
B	1902560	cellular_component	GMP reductase complex
C	0003824	molecular_function	catalytic activity
C	0003920	molecular_function	GMP reductase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006144	biological_process	purine nucleobase metabolic process
C	0006163	biological_process	purine nucleotide metabolic process
C	0009117	biological_process	nucleotide metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0046037	biological_process	GMP metabolic process
C	0046872	molecular_function	metal ion binding
C	1902560	cellular_component	GMP reductase complex
D	0003824	molecular_function	catalytic activity
D	0003920	molecular_function	GMP reductase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006144	biological_process	purine nucleobase metabolic process
D	0006163	biological_process	purine nucleotide metabolic process
D	0009117	biological_process	nucleotide metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0046037	biological_process	GMP metabolic process
D	0046872	molecular_function	metal ion binding
D	1902560	cellular_component	GMP reductase complex
E	0003824	molecular_function	catalytic activity
E	0003920	molecular_function	GMP reductase activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006144	biological_process	purine nucleobase metabolic process
E	0006163	biological_process	purine nucleotide metabolic process
E	0009117	biological_process	nucleotide metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0046037	biological_process	GMP metabolic process
E	0046872	molecular_function	metal ion binding
E	1902560	cellular_component	GMP reductase complex
F	0003824	molecular_function	catalytic activity
F	0003920	molecular_function	GMP reductase activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006144	biological_process	purine nucleobase metabolic process
F	0006163	biological_process	purine nucleotide metabolic process
F	0009117	biological_process	nucleotide metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0046037	biological_process	GMP metabolic process
F	0046872	molecular_function	metal ion binding
F	1902560	cellular_component	GMP reductase complex
G	0003824	molecular_function	catalytic activity
G	0003920	molecular_function	GMP reductase activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006144	biological_process	purine nucleobase metabolic process
G	0006163	biological_process	purine nucleotide metabolic process
G	0009117	biological_process	nucleotide metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0046037	biological_process	GMP metabolic process
G	0046872	molecular_function	metal ion binding
G	1902560	cellular_component	GMP reductase complex
H	0003824	molecular_function	catalytic activity
H	0003920	molecular_function	GMP reductase activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0006144	biological_process	purine nucleobase metabolic process
H	0006163	biological_process	purine nucleotide metabolic process
H	0009117	biological_process	nucleotide metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0046037	biological_process	GMP metabolic process
H	0046872	molecular_function	metal ion binding
H	1902560	cellular_component	GMP reductase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE IMP A 1338

Chain	Residue
A	ALA53
A	GLY242
A	GLY243
A	GLY268
A	MET269
A	SER270
A	GLU289
A	GLY290
A	HOH2142
A	HOH2216
A	HOH2217
A	MET55
A	HOH2218
A	HOH2219
A	GLY183
A	SER184
A	CYS186
A	ASP219
A	GLY220
A	GLY221
A	MET240

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE IMP B 1338

Chain	Residue
B	ALA53
B	MET55
B	GLY183
B	SER184
B	CYS186
B	ASP219
B	GLY220
B	GLY221
B	MET240
B	GLY242
B	GLY243
B	GLY268
B	MET269
B	SER270
B	GLU289
B	GLY290
B	HOH2036
B	HOH2204
B	HOH2207
B	HOH2209
B	HOH2210
B	HOH2211

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE IMP C 1338

Chain	Residue
C	ALA53
C	MET55
C	GLY183
C	SER184
C	CYS186
C	ASP219
C	GLY220
C	GLY221
C	MET240
C	GLY242
C	GLY243
C	GLY268
C	MET269
C	SER270
C	GLU289
C	GLY290
C	HOH2047
C	HOH2160
C	HOH2173
C	HOH2263
C	HOH2264
C	HOH2265
C	HOH2266
C	HOH2267

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE IMP D 1338

Chain	Residue
D	ALA53
D	MET55
D	GLY183
D	SER184
D	CYS186
D	ASP219
D	GLY220
D	GLY221
D	MET240
D	GLY242
D	GLY243
D	GLY268
D	MET269
D	SER270
D	GLU289
D	GLY290
D	HOH2153
D	HOH2221
D	HOH2222
D	HOH2224
D	HOH2225
D	HOH2226

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE IMP E 1338

Chain	Residue
E	GLY243
E	GLY268
E	MET269
E	SER270
E	GLU289
E	GLY290
E	HOH2053
E	HOH2169
E	HOH2279
E	HOH2280
E	HOH2281
E	HOH2282
E	HOH2283
E	ALA53
E	MET55
E	GLY183
E	SER184
E	CYS186
E	ASP219
E	GLY220
E	GLY221
E	MET240
E	GLY242

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE IMP F 1338

Chain	Residue
F	ALA53
F	ASN158
F	GLY183
F	SER184
F	CYS186
F	ASP219
F	GLY220
F	GLY221
F	MET240
F	GLY242
F	GLY243
F	GLY268
F	MET269
F	SER270
F	GLU289
F	GLY290
F	HOH2052
F	HOH2171
F	HOH2254
F	HOH2255
F	HOH2256
F	HOH2257

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE IMP G 1338

Chain	Residue
G	ALA53
G	MET55
G	GLY183
G	SER184
G	CYS186
G	ASP219
G	GLY220
G	GLY221
G	MET240
G	GLY242
G	GLY243
G	GLY268
G	MET269
G	SER270
G	GLU289
G	GLY290
G	HOH2111
G	HOH2124
G	HOH2127
G	HOH2193
G	HOH2194
G	HOH2195
G	HOH2196
G	HOH2197
G	HOH2198

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE IMP H 1338

Chain	Residue
H	ALA53
H	MET55
H	GLY183
H	SER184
H	CYS186
H	ASP219
H	GLY220
H	GLY221
H	MET240
H	GLY242
H	GLY243
H	GLY268
H	MET269
H	SER270
H	GLU289
H	GLY290
H	HOH2047
H	HOH2145
H	HOH2244
H	HOH2247
H	HOH2248
H	HOH2249
H	HOH2250

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKVGIGpGSVCtT

Chain	Residue	Details
A	ILE176-THR188

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255\|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	CYS186
B	CYS186
C	CYS186
D	CYS186
E	CYS186
F	CYS186
G	CYS186
H	CYS186

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	THR188
B	THR188
C	THR188
D	THR188
E	THR188
F	THR188
G	THR188
H	THR188

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03195, ECO:0000269\|PubMed:22037469

Chain	Residue	Details
A	SER26
E	SER314
F	SER26
F	SER314
G	SER26
G	SER314
H	SER26
H	SER314
A	SER314
B	SER26
B	SER314
C	SER26
C	SER314
D	SER26
D	SER314
E	SER26

site_id	SWS_FT_FI4
Number of Residues	40
Details	BINDING: in other chain => ECO:0000255\|HAMAP-Rule:MF_03195, ECO:0000269\|PubMed:22037469

Chain	Residue	Details
A	LYS78
B	TYR285
C	LYS78
C	ASP129
C	ILE180
C	MET269
C	TYR285
D	LYS78
D	ASP129
D	ILE180
D	MET269
A	ASP129
D	TYR285
E	LYS78
E	ASP129
E	ILE180
E	MET269
E	TYR285
F	LYS78
F	ASP129
F	ILE180
F	MET269
A	ILE180
F	TYR285
G	LYS78
G	ASP129
G	ILE180
G	MET269
G	TYR285
H	LYS78
H	ASP129
H	ILE180
H	MET269
A	MET269
H	TYR285
A	TYR285
B	LYS78
B	ASP129
B	ILE180
B	MET269

site_id	SWS_FT_FI5
Number of Residues	64
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	GLY181
B	GLY183
B	CYS186
B	ARG189
B	ASP219
B	GLY242
B	GLY268
B	ARG286
C	GLY181
C	GLY183
C	CYS186
A	GLY183
C	ARG189
C	ASP219
C	GLY242
C	GLY268
C	ARG286
D	GLY181
D	GLY183
D	CYS186
D	ARG189
D	ASP219
A	CYS186
D	GLY242
D	GLY268
D	ARG286
E	GLY181
E	GLY183
E	CYS186
E	ARG189
E	ASP219
E	GLY242
E	GLY268
A	ARG189
E	ARG286
F	GLY181
F	GLY183
F	CYS186
F	ARG189
F	ASP219
F	GLY242
F	GLY268
F	ARG286
G	GLY181
A	ASP219
G	GLY183
G	CYS186
G	ARG189
G	ASP219
G	GLY242
G	GLY268
G	ARG286
H	GLY181
H	GLY183
H	CYS186
A	GLY242
H	ARG189
H	ASP219
H	GLY242
H	GLY268
H	ARG286
A	GLY268
A	ARG286
B	GLY181

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS291
B	LYS291
C	LYS291
D	LYS291
E	LYS291
F	LYS291
G	LYS291
H	LYS291

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)