2BZN

Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003920	molecular_function	GMP reductase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006144	biological_process	purine nucleobase metabolic process
A	0006163	biological_process	purine nucleotide metabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046037	biological_process	GMP metabolic process
A	0046872	molecular_function	metal ion binding
A	1902560	cellular_component	GMP reductase complex
B	0003824	molecular_function	catalytic activity
B	0003920	molecular_function	GMP reductase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006144	biological_process	purine nucleobase metabolic process
B	0006163	biological_process	purine nucleotide metabolic process
B	0009117	biological_process	nucleotide metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0046037	biological_process	GMP metabolic process
B	0046872	molecular_function	metal ion binding
B	1902560	cellular_component	GMP reductase complex
C	0003824	molecular_function	catalytic activity
C	0003920	molecular_function	GMP reductase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006144	biological_process	purine nucleobase metabolic process
C	0006163	biological_process	purine nucleotide metabolic process
C	0009117	biological_process	nucleotide metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0046037	biological_process	GMP metabolic process
C	0046872	molecular_function	metal ion binding
C	1902560	cellular_component	GMP reductase complex
D	0003824	molecular_function	catalytic activity
D	0003920	molecular_function	GMP reductase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006144	biological_process	purine nucleobase metabolic process
D	0006163	biological_process	purine nucleotide metabolic process
D	0009117	biological_process	nucleotide metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0046037	biological_process	GMP metabolic process
D	0046872	molecular_function	metal ion binding
D	1902560	cellular_component	GMP reductase complex
E	0003824	molecular_function	catalytic activity
E	0003920	molecular_function	GMP reductase activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006144	biological_process	purine nucleobase metabolic process
E	0006163	biological_process	purine nucleotide metabolic process
E	0009117	biological_process	nucleotide metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0046037	biological_process	GMP metabolic process
E	0046872	molecular_function	metal ion binding
E	1902560	cellular_component	GMP reductase complex
F	0003824	molecular_function	catalytic activity
F	0003920	molecular_function	GMP reductase activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006144	biological_process	purine nucleobase metabolic process
F	0006163	biological_process	purine nucleotide metabolic process
F	0009117	biological_process	nucleotide metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0046037	biological_process	GMP metabolic process
F	0046872	molecular_function	metal ion binding
F	1902560	cellular_component	GMP reductase complex
G	0003824	molecular_function	catalytic activity
G	0003920	molecular_function	GMP reductase activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006144	biological_process	purine nucleobase metabolic process
G	0006163	biological_process	purine nucleotide metabolic process
G	0009117	biological_process	nucleotide metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0046037	biological_process	GMP metabolic process
G	0046872	molecular_function	metal ion binding
G	1902560	cellular_component	GMP reductase complex
H	0003824	molecular_function	catalytic activity
H	0003920	molecular_function	GMP reductase activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0006144	biological_process	purine nucleobase metabolic process
H	0006163	biological_process	purine nucleotide metabolic process
H	0009117	biological_process	nucleotide metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0046037	biological_process	GMP metabolic process
H	0046872	molecular_function	metal ion binding
H	1902560	cellular_component	GMP reductase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE IMP A 1338

Chain	Residue
A	ALA53
A	GLY242
A	GLY243
A	GLY268
A	MET269
A	SER270
A	GLU289
A	GLY290
A	HOH2142
A	HOH2216
A	HOH2217
A	MET55
A	HOH2218
A	HOH2219
A	GLY183
A	SER184
A	CYS186
A	ASP219
A	GLY220
A	GLY221
A	MET240

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE IMP B 1338

Chain	Residue
B	ALA53
B	MET55
B	GLY183
B	SER184
B	CYS186
B	ASP219
B	GLY220
B	GLY221
B	MET240
B	GLY242
B	GLY243
B	GLY268
B	MET269
B	SER270
B	GLU289
B	GLY290
B	HOH2036
B	HOH2204
B	HOH2207
B	HOH2209
B	HOH2210
B	HOH2211

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE IMP C 1338

Chain	Residue
C	ALA53
C	MET55
C	GLY183
C	SER184
C	CYS186
C	ASP219
C	GLY220
C	GLY221
C	MET240
C	GLY242
C	GLY243
C	GLY268
C	MET269
C	SER270
C	GLU289
C	GLY290
C	HOH2047
C	HOH2160
C	HOH2173
C	HOH2263
C	HOH2264
C	HOH2265
C	HOH2266
C	HOH2267

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE IMP D 1338

Chain	Residue
D	ALA53
D	MET55
D	GLY183
D	SER184
D	CYS186
D	ASP219
D	GLY220
D	GLY221
D	MET240
D	GLY242
D	GLY243
D	GLY268
D	MET269
D	SER270
D	GLU289
D	GLY290
D	HOH2153
D	HOH2221
D	HOH2222
D	HOH2224
D	HOH2225
D	HOH2226

---

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE IMP E 1338

Chain	Residue
E	GLY243
E	GLY268
E	MET269
E	SER270
E	GLU289
E	GLY290
E	HOH2053
E	HOH2169
E	HOH2279
E	HOH2280
E	HOH2281
E	HOH2282
E	HOH2283
E	ALA53
E	MET55
E	GLY183
E	SER184
E	CYS186
E	ASP219
E	GLY220
E	GLY221
E	MET240
E	GLY242

---

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE IMP F 1338

Chain	Residue
F	ALA53
F	ASN158
F	GLY183
F	SER184
F	CYS186
F	ASP219
F	GLY220
F	GLY221
F	MET240
F	GLY242
F	GLY243
F	GLY268
F	MET269
F	SER270
F	GLU289
F	GLY290
F	HOH2052
F	HOH2171
F	HOH2254
F	HOH2255
F	HOH2256
F	HOH2257

---

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE IMP G 1338

Chain	Residue
G	ALA53
G	MET55
G	GLY183
G	SER184
G	CYS186
G	ASP219
G	GLY220
G	GLY221
G	MET240
G	GLY242
G	GLY243
G	GLY268
G	MET269
G	SER270
G	GLU289
G	GLY290
G	HOH2111
G	HOH2124
G	HOH2127
G	HOH2193
G	HOH2194
G	HOH2195
G	HOH2196
G	HOH2197
G	HOH2198

---

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE IMP H 1338

Chain	Residue
H	ALA53
H	MET55
H	GLY183
H	SER184
H	CYS186
H	ASP219
H	GLY220
H	GLY221
H	MET240
H	GLY242
H	GLY243
H	GLY268
H	MET269
H	SER270
H	GLU289
H	GLY290
H	HOH2047
H	HOH2145
H	HOH2244
H	HOH2247
H	HOH2248
H	HOH2249
H	HOH2250

---

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKVGIGpGSVCtT

Chain	Residue	Details
A	ILE176-THR188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Thioimidate intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22037469","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22037469","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03195","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---