2BZL

CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A2185

Chain	Residue
A	ARG1021
A	LYS1025
A	ARG1045
A	HOH2125

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A2186

Chain	Residue
A	HIS1030
A	SER1031
A	SER1032
A	HOH2244

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A2187

Chain	Residue
A	SER1122
A	GLY1126
A	ARG1127
A	GLN1169
A	HOH2225
A	CYS1121

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A2188

Chain	Residue
A	PRO917
A	LYS918
A	LYS919

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG

Chain	Residue	Details
A	VAL1119-GLY1129

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044

Chain	Residue	Details
A	CYS1121

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP1079
A	CYS1121
A	GLN1165

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