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2BUJ

Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0000166molecular_functionnucleotide binding
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005798cellular_componentGolgi-associated vesicle
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006624biological_processvacuolar protein processing
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0032889biological_processregulation of vacuole fusion, non-autophagic
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046777biological_processprotein autophosphorylation
A0048471cellular_componentperinuclear region of cytoplasm
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0106310molecular_functionprotein serine kinase activity
B0000166molecular_functionnucleotide binding
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005798cellular_componentGolgi-associated vesicle
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0006624biological_processvacuolar protein processing
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0032889biological_processregulation of vacuole fusion, non-autophagic
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046777biological_processprotein autophosphorylation
B0048471cellular_componentperinuclear region of cytoplasm
B0071560biological_processcellular response to transforming growth factor beta stimulus
B0106310molecular_functionprotein serine kinase activity
PDBデータベースに由来する情報
site_idAC1
残基数2
詳細BINDING SITE FOR RESIDUE CL A1300
鎖名残基
AARG59
ASTU1302

site_idAC2
残基数2
詳細BINDING SITE FOR RESIDUE CL B1298
鎖名残基
BGLY30
BSER32

site_idAC3
残基数8
詳細BINDING SITE FOR RESIDUE STU A1301
鎖名残基
APHE100
APHE101
AMET165
ALEU26
AGLU28
AVAL34
AALA47
APRO99

site_idAC4
残基数5
詳細BINDING SITE FOR RESIDUE STU A1302
鎖名残基
AGLU87
AHIS92
ACL1300
BGLN24
BSTU1300

site_idAC5
残基数9
詳細BINDING SITE FOR RESIDUE STU B1299
鎖名残基
BLEU26
BGLY27
BGLU28
BALA47
BPRO99
BPHE100
BPHE101
BMET165
BSTU1300

site_idAC6
残基数11
詳細BINDING SITE FOR RESIDUE STU B1300
鎖名残基
AHIS54
AGLU55
ASTU1302
BGLN24
BLEU26
BPHE45
BPHE100
BLYS102
BARG103
BGLY104
BSTU1299

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00108
残基数13
詳細PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YaHrDLKptNILL
鎖名残基詳細
ATYR144-LEU156

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数2
詳細ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
鎖名残基詳細
ALEU149
BLEU149

site_idSWS_FT_FI2
残基数4
詳細BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
鎖名残基詳細
AGLY27
AARG50
BGLY27
BARG50

site_idSWS_FT_FI3
残基数2
詳細MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:18184589
鎖名残基詳細
ALEU186
BLEU186

site_idSWS_FT_FI4
残基数2
詳細MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:18184589
鎖名残基詳細
ATYR198
BTYR198

site_idSWS_FT_FI5
残基数2
詳細MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:18184589
鎖名残基詳細
AARG199
BARG199

218853

件を2024-04-24に公開中

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