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Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide

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Functional Information from GO Data

ChainGOidnamespacecontents
B0044295cellular_componentaxonal growth cone
B0009986cellular_componentcell surface
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0044294cellular_componentdendritic growth cone
B0071682cellular_componentendocytic vesicle lumen
B0070062cellular_componentextracellular exosome
B0005576cellular_componentextracellular region
B1904813cellular_componentficolin-1-rich granule lumen
B0043202cellular_componentlysosomal lumen
B0042470cellular_componentmelanosome
B0016020cellular_componentmembrane
B0043209cellular_componentmyelin sheath
B0043025cellular_componentneuronal cell body
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0048471cellular_componentperinuclear region of cytoplasm
B0005886cellular_componentplasma membrane
B0032991cellular_componentprotein-containing complex
B0034774cellular_componentsecretory granule lumen
B0005524molecular_functionATP binding
B0016887molecular_functionATPase activity
B0042623molecular_functionATPase activity, coupled
B0097718molecular_functiondisordered domain specific binding
B0070182molecular_functionDNA polymerase binding
B0051020molecular_functionGTPase binding
B0042826molecular_functionhistone deacetylase binding
B0042802molecular_functionidentical protein binding
B0023026molecular_functionMHC class II protein complex binding
B0030235molecular_functionnitric-oxide synthase regulator activity
B0000166molecular_functionnucleotide binding
B0042803molecular_functionprotein homodimerization activity
B1990782molecular_functionprotein tyrosine kinase binding
B0003723molecular_functionRNA binding
B0097110molecular_functionscaffold protein binding
B0048156molecular_functiontau protein binding
B0030911molecular_functionTPR domain binding
B0031625molecular_functionubiquitin protein ligase binding
B0051082molecular_functionunfolded protein binding
B0048675biological_processaxon extension
B0034605biological_processcellular response to heat
B0021955biological_processcentral nervous system neuron axonogenesis
B0061684biological_processchaperone-mediated autophagy
B0051131biological_processchaperone-mediated protein complex assembly
B0097711biological_processciliary basal body-plasma membrane docking
B0051186biological_processcofactor metabolic process
B0019221biological_processcytokine-mediated signaling pathway
B0038128biological_processERBB2 signaling pathway
B0030010biological_processestablishment of cell polarity
B0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
B0000086biological_processG2/M transition of mitotic cell cycle
B0006839biological_processmitochondrial transport
B0043312biological_processneutrophil degranulation
B1903364biological_processpositive regulation of cellular protein catabolic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0051897biological_processpositive regulation of protein kinase B signaling
B0001934biological_processpositive regulation of protein phosphorylation
B0032273biological_processpositive regulation of protein polymerization
B1902949biological_processpositive regulation of tau-protein kinase activity
B0051973biological_processpositive regulation of telomerase activity
B0006457biological_processprotein folding
B0045040biological_processprotein import into mitochondrial outer membrane
B0042026biological_processprotein refolding
B0050821biological_processprotein stabilization
B0043335biological_processprotein unfolding
B0006898biological_processreceptor-mediated endocytosis
B1903827biological_processregulation of cellular protein localization
B1900034biological_processregulation of cellular response to heat
B0010389biological_processregulation of G2/M transition of mitotic cell cycle
B0050999biological_processregulation of nitric-oxide synthase activity
B0043254biological_processregulation of protein complex assembly
B0031396biological_processregulation of protein ubiquitination
B0046677biological_processresponse to antibiotic
B0009409biological_processresponse to cold
B0009408biological_processresponse to heat
B0006986biological_processresponse to unfolded protein
B0007165biological_processsignal transduction
B1905323biological_processtelomerase holoenzyme complex assembly
B0007004biological_processtelomere maintenance via telomerase
B0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0101031cellular_componentchaperone complex
A0005829cellular_componentcytosol
A0043231cellular_componentintracellular membrane-bounded organelle
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0043204cellular_componentperikaryon
A0005886cellular_componentplasma membrane
A0032991cellular_componentprotein-containing complex
A1990635cellular_componentproximal dendrite
A0043531molecular_functionADP binding
A0005524molecular_functionATP binding
A0001965molecular_functionG-protein alpha-subunit binding
A0051879molecular_functionHsp90 protein binding
A0042802molecular_functionidentical protein binding
A0008289molecular_functionlipid binding
A0046872molecular_functionmetal ion binding
A0008017molecular_functionmicrotubule binding
A0016791molecular_functionphosphatase activity
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0003723molecular_functionRNA binding
A0048156molecular_functiontau protein binding
A0071276biological_processcellular response to cadmium ion
A0070301biological_processcellular response to hydrogen peroxide
A0006281biological_processDNA repair
A0016576biological_processhistone dephosphorylation
A0000165biological_processMAPK cascade
A0000278biological_processmitotic cell cycle
A1901215biological_processnegative regulation of neuron death
A0001933biological_processnegative regulation of protein phosphorylation
A0070262biological_processpeptidyl-serine dephosphorylation
A0035970biological_processpeptidyl-threonine dephosphorylation
A2000324biological_processpositive regulation of glucocorticoid receptor signaling pathway
A0043123biological_processpositive regulation of I-kappaB kinase/NF-kappaB signaling
A0006470biological_processprotein dephosphorylation
A0051291biological_processprotein heterooligomerization
A1904550biological_processresponse to arachidonic acid
A0010288biological_processresponse to lead ion
A0043278biological_processresponse to morphine
A0006351biological_processtranscription, DNA-templated
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Proton donor (By similarity).
ChainResidueDetails
ANA*

SWS_FT_FI24Manganese (By similarity)
ChainResidueDetails
ANA*
ANA*
ANA*
ANA*

SWS_FT_FI33Iron (By similarity)
ChainResidueDetails
ANA*
ANA*
ANA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails