2BU2
crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0005829 | cellular_component | cytosol |
A | 0006006 | biological_process | glucose metabolic process |
A | 0006111 | biological_process | regulation of gluconeogenesis |
A | 0006885 | biological_process | regulation of pH |
A | 0008286 | biological_process | insulin receptor signaling pathway |
A | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
A | 0010565 | biological_process | regulation of ketone metabolic process |
A | 0010906 | biological_process | regulation of glucose metabolic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0031670 | biological_process | cellular response to nutrient |
A | 0033554 | biological_process | cellular response to stress |
A | 0034614 | biological_process | cellular response to reactive oxygen species |
A | 0042593 | biological_process | glucose homeostasis |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
A | 0050848 | biological_process | regulation of calcium-mediated signaling |
A | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A1388 |
Chain | Residue |
A | ASN247 |
A | ATP1386 |
A | HOH2040 |
A | HOH2087 |
site_id | AC2 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE ATP A1386 |
Chain | Residue |
A | VAL287 |
A | LEU295 |
A | LEU315 |
A | ALA316 |
A | GLY317 |
A | PHE318 |
A | GLY319 |
A | TYR320 |
A | GLY321 |
A | LEU322 |
A | PRO323 |
A | THR346 |
A | MG1388 |
A | HOH2040 |
A | HOH2057 |
A | HOH2084 |
A | HOH2085 |
A | HOH2086 |
A | HOH2087 |
A | HOH2088 |
A | HOH2090 |
A | GLU243 |
A | ASN247 |
A | ARG250 |
A | ALA251 |
A | ASP282 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TF1 A1387 |
Chain | Residue |
A | LEU23 |
A | GLN27 |
A | PHE28 |
A | PHE31 |
A | SER41 |
A | PHE44 |
A | LEU45 |
A | LEU160 |
A | GLN163 |
A | HOH2091 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 13 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"16401071","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q15118","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BFP9","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1jm6 |
Chain | Residue | Details |
A | GLU243 | |
A | HIS239 |