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2BU2

crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004672molecular_functionprotein kinase activity
A0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006111biological_processregulation of gluconeogenesis
A0006885biological_processregulation of pH
A0008286biological_processinsulin receptor signaling pathway
A0010510biological_processregulation of pyruvate decarboxylation to acetyl-CoA
A0010565biological_processregulation of ketone metabolic process
A0010906biological_processregulation of glucose metabolic process
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0031670biological_processcellular response to nutrient
A0033554biological_processcellular response to stress
A0034614biological_processcellular response to reactive oxygen species
A0042593biological_processglucose homeostasis
A0042803molecular_functionprotein homodimerization activity
A0045254cellular_componentpyruvate dehydrogenase complex
A0050848biological_processregulation of calcium-mediated signaling
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A1388
ChainResidue
AASN247
AATP1386
AHOH2040
AHOH2087

site_idAC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE ATP A1386
ChainResidue
AVAL287
ALEU295
ALEU315
AALA316
AGLY317
APHE318
AGLY319
ATYR320
AGLY321
ALEU322
APRO323
ATHR346
AMG1388
AHOH2040
AHOH2057
AHOH2084
AHOH2085
AHOH2086
AHOH2087
AHOH2088
AHOH2090
AGLU243
AASN247
AARG250
AALA251
AASP282

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE TF1 A1387
ChainResidue
ALEU23
AGLN27
APHE28
APHE31
ASER41
APHE44
ALEU45
ALEU160
AGLN163
AHOH2091

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues13
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16401071","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q15118","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BFP9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1jm6
ChainResidueDetails
AGLU243
AHIS239

238582

PDB entries from 2025-07-09

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