2BTY
Acetylglutamate kinase from Thermotoga maritima complexed with its inhibitor arginine
Replaces: 1UVVFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003991 | molecular_function | acetylglutamate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003991 | molecular_function | acetylglutamate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003991 | molecular_function | acetylglutamate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006526 | biological_process | L-arginine biosynthetic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE K A1285 |
| Chain | Residue |
| A | ASP160 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ARG A1283 |
| Chain | Residue |
| A | LYS271 |
| A | GLY274 |
| A | MET276 |
| A | HOH2015 |
| A | TYR15 |
| A | PHE19 |
| A | LYS196 |
| A | SER214 |
| A | GLU266 |
| A | ILE267 |
| A | SER269 |
| A | ARG270 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ARG B1283 |
| Chain | Residue |
| B | TYR15 |
| B | PHE19 |
| B | LYS196 |
| B | SER214 |
| B | THR215 |
| B | GLU266 |
| B | ILE267 |
| B | SER269 |
| B | ARG270 |
| B | LYS271 |
| B | GLY274 |
| B | MET276 |
| B | HOH2015 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ARG C1283 |
| Chain | Residue |
| C | PHE19 |
| C | LYS196 |
| C | SER214 |
| C | THR215 |
| C | GLU266 |
| C | ILE267 |
| C | SER269 |
| C | ARG270 |
| C | LYS271 |
| C | GLY272 |
| C | GLY274 |
| C | MET276 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NLG A1284 |
| Chain | Residue |
| A | LYS27 |
| A | GLY29 |
| A | GLY30 |
| A | GLY61 |
| A | GLY62 |
| A | ASN180 |
| A | ASP182 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NLG B1284 |
| Chain | Residue |
| B | LYS27 |
| B | GLY29 |
| B | GLY30 |
| B | GLY61 |
| B | ASN180 |
| B | ASP182 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NLG C1284 |
| Chain | Residue |
| C | LYS27 |
| C | GLY30 |
| C | GLY61 |
| C | GLY62 |
| C | GLY63 |
| C | ILE179 |
| C | ASN180 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00082","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00082","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16376937","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16376937","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BTY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00082","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1oh9 |
| Chain | Residue | Details |
| A | LYS237 | |
| A | GLY30 | |
| A | GLY63 | |
| A | LYS27 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1oh9 |
| Chain | Residue | Details |
| B | LYS237 | |
| B | GLY30 | |
| B | GLY63 | |
| B | LYS27 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1oh9 |
| Chain | Residue | Details |
| C | LYS237 | |
| C | GLY30 | |
| C | GLY63 | |
| C | LYS27 |
