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2BRW

Crystal structure of Streptococcus Pneumoniae Hyaluronate Lyase from 30percent PEGMME.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0005576cellular_componentextracellular region
A0005975biological_processcarbohydrate metabolic process
A0016829molecular_functionlyase activity
A0030246molecular_functioncarbohydrate binding
B0003824molecular_functioncatalytic activity
B0005576cellular_componentextracellular region
B0005975biological_processcarbohydrate metabolic process
B0016829molecular_functionlyase activity
B0030246molecular_functioncarbohydrate binding
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A1891
ChainResidue
AHIS578
ALYS581
ALYS584

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B1891
ChainResidue
BHIS578
BLYS581
BLYS584

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:10716923
ChainResidueDetails
AASN349
AHIS399
ATYR408
BASN349
BHIS399
BTYR408

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c82
ChainResidueDetails
ATYR408
AASN349
AHIS399

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c82
ChainResidueDetails
BTYR408
BASN349
BHIS399

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c82
ChainResidueDetails
ATYR408
AARG462
AHIS399

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c82
ChainResidueDetails
BTYR408
BARG462
BHIS399

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c82
ChainResidueDetails
AARG480
ATYR408
AHIS399

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1c82
ChainResidueDetails
BARG480
BTYR408
BHIS399

site_idMCSA1
Number of Residues4
DetailsM-CSA 439
ChainResidueDetails
AASN349modifies pKa
AHIS399modifies pKa
ATYR408proton shuttle (general acid/base)
AARG462modifies pKa

site_idMCSA2
Number of Residues4
DetailsM-CSA 439
ChainResidueDetails
BASN349modifies pKa
BHIS399modifies pKa
BTYR408proton shuttle (general acid/base)
BARG462modifies pKa

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PDB entries from 2024-10-30

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