Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BR2

RNase PH core of the archaeal exosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000177	cellular_component	cytoplasmic exosome (RNase complex)
A	0000178	cellular_component	exosome (RNase complex)
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006401	biological_process	RNA catabolic process
A	0016075	biological_process	rRNA catabolic process
A	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0000177	cellular_component	cytoplasmic exosome (RNase complex)
B	0000178	cellular_component	exosome (RNase complex)
B	0003723	molecular_function	RNA binding
B	0004527	molecular_function	exonuclease activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006401	biological_process	RNA catabolic process
B	0016075	biological_process	rRNA catabolic process
B	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
C	0000177	cellular_component	cytoplasmic exosome (RNase complex)
C	0000178	cellular_component	exosome (RNase complex)
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006401	biological_process	RNA catabolic process
C	0016075	biological_process	rRNA catabolic process
C	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0000177	cellular_component	cytoplasmic exosome (RNase complex)
D	0000178	cellular_component	exosome (RNase complex)
D	0003723	molecular_function	RNA binding
D	0004527	molecular_function	exonuclease activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006401	biological_process	RNA catabolic process
D	0016075	biological_process	rRNA catabolic process
D	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
E	0000177	cellular_component	cytoplasmic exosome (RNase complex)
E	0000178	cellular_component	exosome (RNase complex)
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006401	biological_process	RNA catabolic process
E	0016075	biological_process	rRNA catabolic process
E	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
F	0000175	molecular_function	3'-5'-RNA exonuclease activity
F	0000177	cellular_component	cytoplasmic exosome (RNase complex)
F	0000178	cellular_component	exosome (RNase complex)
F	0003723	molecular_function	RNA binding
F	0004527	molecular_function	exonuclease activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006401	biological_process	RNA catabolic process
F	0016075	biological_process	rRNA catabolic process
F	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
G	0000177	cellular_component	cytoplasmic exosome (RNase complex)
G	0000178	cellular_component	exosome (RNase complex)
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006401	biological_process	RNA catabolic process
G	0016075	biological_process	rRNA catabolic process
G	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
H	0000175	molecular_function	3'-5'-RNA exonuclease activity
H	0000177	cellular_component	cytoplasmic exosome (RNase complex)
H	0000178	cellular_component	exosome (RNase complex)
H	0003723	molecular_function	RNA binding
H	0004527	molecular_function	exonuclease activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006401	biological_process	RNA catabolic process
H	0016075	biological_process	rRNA catabolic process
H	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
I	0000177	cellular_component	cytoplasmic exosome (RNase complex)
I	0000178	cellular_component	exosome (RNase complex)
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0006401	biological_process	RNA catabolic process
I	0016075	biological_process	rRNA catabolic process
I	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
J	0000175	molecular_function	3'-5'-RNA exonuclease activity
J	0000177	cellular_component	cytoplasmic exosome (RNase complex)
J	0000178	cellular_component	exosome (RNase complex)
J	0003723	molecular_function	RNA binding
J	0004527	molecular_function	exonuclease activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0006401	biological_process	RNA catabolic process
J	0016075	biological_process	rRNA catabolic process
J	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
K	0000177	cellular_component	cytoplasmic exosome (RNase complex)
K	0000178	cellular_component	exosome (RNase complex)
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0006401	biological_process	RNA catabolic process
K	0016075	biological_process	rRNA catabolic process
K	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
L	0000175	molecular_function	3'-5'-RNA exonuclease activity
L	0000177	cellular_component	cytoplasmic exosome (RNase complex)
L	0000178	cellular_component	exosome (RNase complex)
L	0003723	molecular_function	RNA binding
L	0004527	molecular_function	exonuclease activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006401	biological_process	RNA catabolic process
L	0016075	biological_process	rRNA catabolic process
L	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
M	0000177	cellular_component	cytoplasmic exosome (RNase complex)
M	0000178	cellular_component	exosome (RNase complex)
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0006401	biological_process	RNA catabolic process
M	0016075	biological_process	rRNA catabolic process
M	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
N	0000175	molecular_function	3'-5'-RNA exonuclease activity
N	0000177	cellular_component	cytoplasmic exosome (RNase complex)
N	0000178	cellular_component	exosome (RNase complex)
N	0003723	molecular_function	RNA binding
N	0004527	molecular_function	exonuclease activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0006401	biological_process	RNA catabolic process
N	0016075	biological_process	rRNA catabolic process
N	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
O	0000177	cellular_component	cytoplasmic exosome (RNase complex)
O	0000178	cellular_component	exosome (RNase complex)
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0006401	biological_process	RNA catabolic process
O	0016075	biological_process	rRNA catabolic process
O	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
P	0000175	molecular_function	3'-5'-RNA exonuclease activity
P	0000177	cellular_component	cytoplasmic exosome (RNase complex)
P	0000178	cellular_component	exosome (RNase complex)
P	0003723	molecular_function	RNA binding
P	0004527	molecular_function	exonuclease activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0006401	biological_process	RNA catabolic process
P	0016075	biological_process	rRNA catabolic process
P	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
Q	0000177	cellular_component	cytoplasmic exosome (RNase complex)
Q	0000178	cellular_component	exosome (RNase complex)
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0006401	biological_process	RNA catabolic process
Q	0016075	biological_process	rRNA catabolic process
Q	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
R	0000175	molecular_function	3'-5'-RNA exonuclease activity
R	0000177	cellular_component	cytoplasmic exosome (RNase complex)
R	0000178	cellular_component	exosome (RNase complex)
R	0003723	molecular_function	RNA binding
R	0004527	molecular_function	exonuclease activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0006401	biological_process	RNA catabolic process
R	0016075	biological_process	rRNA catabolic process
R	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
S	0000177	cellular_component	cytoplasmic exosome (RNase complex)
S	0000178	cellular_component	exosome (RNase complex)
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0006401	biological_process	RNA catabolic process
S	0016075	biological_process	rRNA catabolic process
S	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
T	0000175	molecular_function	3'-5'-RNA exonuclease activity
T	0000177	cellular_component	cytoplasmic exosome (RNase complex)
T	0000178	cellular_component	exosome (RNase complex)
T	0003723	molecular_function	RNA binding
T	0004527	molecular_function	exonuclease activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0006401	biological_process	RNA catabolic process
T	0016075	biological_process	rRNA catabolic process
T	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
U	0000177	cellular_component	cytoplasmic exosome (RNase complex)
U	0000178	cellular_component	exosome (RNase complex)
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0006401	biological_process	RNA catabolic process
U	0016075	biological_process	rRNA catabolic process
U	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
V	0000175	molecular_function	3'-5'-RNA exonuclease activity
V	0000177	cellular_component	cytoplasmic exosome (RNase complex)
V	0000178	cellular_component	exosome (RNase complex)
V	0003723	molecular_function	RNA binding
V	0004527	molecular_function	exonuclease activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0006401	biological_process	RNA catabolic process
V	0016075	biological_process	rRNA catabolic process
V	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters
W	0000177	cellular_component	cytoplasmic exosome (RNase complex)
W	0000178	cellular_component	exosome (RNase complex)
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0006401	biological_process	RNA catabolic process
W	0016075	biological_process	rRNA catabolic process
W	0035925	molecular_function	mRNA 3'-UTR AU-rich region binding
X	0000175	molecular_function	3'-5'-RNA exonuclease activity
X	0000177	cellular_component	cytoplasmic exosome (RNase complex)
X	0000178	cellular_component	exosome (RNase complex)
X	0003723	molecular_function	RNA binding
X	0004527	molecular_function	exonuclease activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0006401	biological_process	RNA catabolic process
X	0016075	biological_process	rRNA catabolic process
X	0016896	molecular_function	RNA exonuclease activity, producing 5'-phosphomonoesters

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B1249

Chain	Residue
B	ARG99
B	GLY137
B	SER138
B	ARG139

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D1249

Chain	Residue
D	ARG99
D	GLY137
D	SER138
D	ARG139

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F1249

Chain	Residue
F	SER138
F	ARG139
F	GLY137

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H1249

Chain	Residue
H	ARG99
H	GLY137
H	SER138
H	ARG139

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL J1249

Chain	Residue
J	ARG99
J	SER138
J	ARG139

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL L1249

Chain	Residue
L	ARG99
L	SER138
L	ARG139

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL M1276

Chain	Residue
M	ARG112

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL N1249

Chain	Residue
N	ARG99
N	GLY137
N	SER138
N	ARG139

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL P1249

Chain	Residue
P	ARG99
P	SER138
P	ARG139

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL R1249

Chain	Residue
R	ARG99
R	GLY137
R	SER138
R	ARG139

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL T1249

Chain	Residue
T	ARG99
T	GLY137
T	SER138
T	ARG139

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL V1249

Chain	Residue
V	ARG99
V	GLY137
V	SER138
V	ARG139

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL X1249

Chain	Residue
X	ARG99
X	GLY137
X	SER138
X	ARG139

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)