2BP5

MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH NON-CANONICAL INTERNALIZATION PEPTIDE VEDYEQGLSG

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0002092	biological_process	positive regulation of receptor internalization
M	0005048	molecular_function	signal sequence binding
M	0005515	molecular_function	protein binding
M	0005886	cellular_component	plasma membrane
M	0005905	cellular_component	clathrin-coated pit
M	0006886	biological_process	intracellular protein transport
M	0006897	biological_process	endocytosis
M	0006900	biological_process	vesicle budding from membrane
M	0008021	cellular_component	synaptic vesicle
M	0008289	molecular_function	lipid binding
M	0015031	biological_process	protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030122	cellular_component	AP-2 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0031410	cellular_component	cytoplasmic vesicle
M	0031623	biological_process	receptor internalization
M	0035615	molecular_function	clathrin adaptor activity
M	0043195	cellular_component	terminal bouton
M	0044325	molecular_function	transmembrane transporter binding
M	0045202	cellular_component	synapse
M	0048488	biological_process	synaptic vesicle endocytosis
M	0050750	molecular_function	low-density lipoprotein particle receptor binding
M	0051649	biological_process	establishment of localization in cell
M	0065003	biological_process	protein-containing complex assembly
M	0072583	biological_process	clathrin-dependent endocytosis
M	0097494	biological_process	regulation of vesicle size
M	0097718	molecular_function	disordered domain specific binding
M	0098794	cellular_component	postsynapse
M	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
M	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
M	0098978	cellular_component	glutamatergic synapse
M	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
M	1903077	biological_process	negative regulation of protein localization to plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE

Chain	Residue	Details
M	ILE159-GLU179

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site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY

Chain	Residue	Details
M	ILE263-TYR277

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:12086608, ECO:0000305|PubMed:25061211, ECO:0007744|PDB:2VGL, ECO:0007744|PDB:4UQI

Chain	Residue	Details
M	LYS341
M	LYS345
M	LYS354

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96CW1

Chain	Residue	Details
M	SER45

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q96CW1

Chain	Residue	Details
M	THR156

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