Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2BP5

MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH NON-CANONICAL INTERNALIZATION PEPTIDE VEDYEQGLSG

Functional Information from GO Data
ChainGOidnamespacecontents
M0002092biological_processpositive regulation of receptor internalization
M0005048molecular_functionsignal sequence binding
M0005515molecular_functionprotein binding
M0005886cellular_componentplasma membrane
M0005905cellular_componentclathrin-coated pit
M0006886biological_processintracellular protein transport
M0006897biological_processendocytosis
M0006900biological_processvesicle budding from membrane
M0008021cellular_componentsynaptic vesicle
M0008289molecular_functionlipid binding
M0015031biological_processprotein transport
M0016020cellular_componentmembrane
M0016192biological_processvesicle-mediated transport
M0030122cellular_componentAP-2 adaptor complex
M0030131cellular_componentclathrin adaptor complex
M0031410cellular_componentcytoplasmic vesicle
M0031623biological_processreceptor internalization
M0035615molecular_functionclathrin adaptor activity
M0043195cellular_componentterminal bouton
M0044325molecular_functiontransmembrane transporter binding
M0045202cellular_componentsynapse
M0048488biological_processsynaptic vesicle endocytosis
M0050750molecular_functionlow-density lipoprotein particle receptor binding
M0065003biological_processprotein-containing complex assembly
M0072583biological_processclathrin-dependent endocytosis
M0097494biological_processregulation of vesicle size
M0097718molecular_functiondisordered domain specific binding
M0098794cellular_componentpostsynapse
M0098884biological_processpostsynaptic neurotransmitter receptor internalization
M0098894cellular_componentextrinsic component of presynaptic endocytic zone membrane
M0098978cellular_componentglutamatergic synapse
M1900244biological_processpositive regulation of synaptic vesicle endocytosis
M1903077biological_processnegative regulation of protein localization to plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00990
Number of Residues21
DetailsCLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE
ChainResidueDetails
MILE159-GLU179

site_idPS00991
Number of Residues15
DetailsCLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY
ChainResidueDetails
MILE263-TYR277

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12086608","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25061211","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UQI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

PDB statisticsPDBj update infoContact PDBjnumon