2BMA

The crystal structure of Plasmodium falciparum glutamate dehydrogenase, a putative target for novel antimalarial drugs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
A	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
B	0000166	molecular_function	nucleotide binding
B	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
B	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C	0000166	molecular_function	nucleotide binding
C	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
C	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
D	0000166	molecular_function	nucleotide binding
D	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
D	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
D	0005829	cellular_component	cytosol
D	0006520	biological_process	amino acid metabolic process
D	0006537	biological_process	glutamate biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
E	0000166	molecular_function	nucleotide binding
E	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
E	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
E	0005829	cellular_component	cytosol
E	0006520	biological_process	amino acid metabolic process
E	0006537	biological_process	glutamate biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
F	0000166	molecular_function	nucleotide binding
F	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
F	0004354	molecular_function	glutamate dehydrogenase (NADP+) activity
F	0005829	cellular_component	cytosol
F	0006520	biological_process	amino acid metabolic process
F	0006537	biological_process	glutamate biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Functional Information from PROSITE/UniProt

site_id	PS00074
Number of Residues	14
Details	GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LsmGGGKgGsdfDP

Chain	Residue	Details
A	LEU119-PRO132

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1hrd

Chain	Residue	Details
A	LYS125
A	ASP165

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1hrd

Chain	Residue	Details
B	LYS125
B	ASP165

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1hrd

Chain	Residue	Details
C	LYS125
C	ASP165

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1hrd

Chain	Residue	Details
D	LYS125
D	ASP165

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site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1hrd

Chain	Residue	Details
E	LYS125
E	ASP165

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site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1hrd

Chain	Residue	Details
F	LYS125
F	ASP165

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