2BLE

Structure of human guanosine monophosphate reductase GMPR1 in complex with GMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003920	molecular_function	GMP reductase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006144	biological_process	purine nucleobase metabolic process
A	0006163	biological_process	purine nucleotide metabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0009409	biological_process	response to cold
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	1902560	cellular_component	GMP reductase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A1345

Chain	Residue
A	THR57
A	SER246
A	GLY247
A	HOH2102

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A1346

Chain	Residue
A	SER105
A	GLU140

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site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE 5GP A1344

Chain	Residue
A	SER184
A	CYS186
A	ASP219
A	GLY220
A	GLY221
A	MET240
A	LEU241
A	GLY242
A	GLY243
A	GLY268
A	MET269
A	SER270
A	SER271
A	ARG286
A	ALA287
A	SER288
A	GLY290
A	HOH2077
A	HOH2078
A	HOH2082
A	HOH2100
A	HOH2124
A	HOH2125
A	HOH2126
A	ALA53
A	MET55
A	GLY183

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Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKVGVGpGSVCtT

Chain	Residue	Details
A	ILE176-THR188

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	CYS186

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	THR188

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	SER26
A	SER314

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site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03195

Chain	Residue	Details
A	LYS78
A	ASP129
A	VAL180
A	MET269
A	TYR285

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site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|Ref.8

Chain	Residue	Details
A	GLY181
A	GLY183
A	CYS186
A	ARG189
A	ASP219
A	GLY242
A	GLY268
A	ARG286

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 982

Chain	Residue	Details
A	CYS186	nucleofuge, nucleophile
A	THR188	proton acceptor, proton donor, proton relay
A	GLU289	proton donor

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