Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BL2

The membrane rotor of the V-type ATPase from Enterococcus hirae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0015078	molecular_function	proton transmembrane transporter activity
A	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
A	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
A	0042802	molecular_function	identical protein binding
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0015078	molecular_function	proton transmembrane transporter activity
B	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
B	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
B	0042802	molecular_function	identical protein binding
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0015078	molecular_function	proton transmembrane transporter activity
C	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
C	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
C	0042802	molecular_function	identical protein binding
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0015078	molecular_function	proton transmembrane transporter activity
D	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
D	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
D	0042802	molecular_function	identical protein binding
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0015078	molecular_function	proton transmembrane transporter activity
E	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
E	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
E	0042802	molecular_function	identical protein binding
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006814	biological_process	sodium ion transport
F	0015078	molecular_function	proton transmembrane transporter activity
F	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
F	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
F	0042802	molecular_function	identical protein binding
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006814	biological_process	sodium ion transport
G	0015078	molecular_function	proton transmembrane transporter activity
G	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
G	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
G	0042802	molecular_function	identical protein binding
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006814	biological_process	sodium ion transport
H	0015078	molecular_function	proton transmembrane transporter activity
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
H	0042802	molecular_function	identical protein binding
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006814	biological_process	sodium ion transport
I	0015078	molecular_function	proton transmembrane transporter activity
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
I	0042802	molecular_function	identical protein binding
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0006811	biological_process	monoatomic ion transport
J	0006814	biological_process	sodium ion transport
J	0015078	molecular_function	proton transmembrane transporter activity
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
J	0042802	molecular_function	identical protein binding
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A1157

Chain	Residue
A	LEU61
A	PRO62
A	THR64
A	GLN65
A	GLN110
A	GLU139

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B1157

Chain	Residue
B	GLN65
B	GLN110
B	GLU139
B	LEU61
B	PRO62
B	THR64

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C1157

Chain	Residue
C	LEU61
C	PRO62
C	THR64
C	GLN65
C	GLN110
C	GLU139

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D1157

Chain	Residue
D	LEU61
D	PRO62
D	THR64
D	GLN65
D	GLN110
D	GLU139

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E1157

Chain	Residue
E	LEU61
E	PRO62
E	THR64
E	GLN65
E	GLN110
E	GLU139

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA F1157

Chain	Residue
F	LEU61
F	PRO62
F	THR64
F	GLN65
F	GLN110
F	GLU139

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA G1157

Chain	Residue
G	LEU61
G	PRO62
G	THR64
G	GLN65
G	GLN110
G	GLU139

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H1157

Chain	Residue
H	LEU61
H	PRO62
H	THR64
H	GLN65
H	GLN110
H	GLU139

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA I1157

Chain	Residue
I	LEU61
I	PRO62
I	THR64
I	GLN65
I	GLN110
I	GLU139

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA J1157

Chain	Residue
J	LEU61
J	PRO62
J	THR64
J	GLN65
J	GLN110
J	GLU139

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LHG A1158

Chain	Residue
A	LEU17
A	THR21
A	PHE105
A	HOH2032
B	LYS32
B	LHG1159
J	PHE101
J	PHE105
J	LHG1158

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG A1159

Chain	Residue
A	MET1
A	MET2
A	LEU17
A	LHG1164
I	LHG1165
J	LHG1158

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LHG A1160

Chain	Residue
J	LHG1158

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UMQ A1162

Chain	Residue
A	GLN54

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ A1163

Chain	Residue
A	GLU50
A	PHE52
A	GLY53

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG A1164

Chain	Residue
A	LHG1159
B	MET1
B	MET2
B	LEU17
C	LHG1159

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LHG B1158

Chain	Residue
A	PHE101
A	PHE105
B	LEU17
B	THR21
B	HOH2033
C	LYS32
C	LHG1160

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LHG B1159

Chain	Residue
A	LHG1158

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ B1163

Chain	Residue
B	GLU50
B	PHE52
B	GLY53

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG C1158

Chain	Residue
C	PHE105
C	HOH2021
D	LYS32
B	PHE101
C	LEU17
C	THR21

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG C1159

Chain	Residue
A	LHG1164
C	MET1
C	MET2
C	LEU17
C	LHG1163

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LHG C1160

Chain	Residue
B	LHG1158

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ C1162

Chain	Residue
C	GLU50
C	GLY53
C	GLN54

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG C1163

Chain	Residue
C	LHG1159
D	MET1
D	MET2
D	LEU17
D	LHG1162

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE UMQ C1164

Chain	Residue
C	GLN54
C	PRO125
C	THR129
F	LYS123
F	LYS124
F	GLU126

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LHG D1158

Chain	Residue
C	PHE101
C	PHE105
D	LEU17
D	THR21
D	HOH2026
E	LYS32

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UMQ D1161

Chain	Residue
D	GLU50
D	GLY53

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG D1162

Chain	Residue
C	LHG1163
E	MET1
E	MET2
E	LEU17
F	LHG1159

site_id	DC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LHG E1158

Chain	Residue
D	PHE101
D	PHE105
E	LEU17
E	THR21
E	HOH2028
F	LYS32
F	LHG1160

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ E1160

Chain	Residue
E	GLU50
E	GLY53
E	GLN54

site_id	DC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LHG F1158

Chain	Residue
E	PHE101
F	LEU17
F	THR21
F	PHE105
F	LHG1160
F	LHG1161
F	HOH2034
G	LYS32

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG F1159

Chain	Residue
D	LHG1162
F	MET1
F	MET2
F	LEU17
F	LHG1164

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LHG F1160

Chain	Residue
E	LHG1158
F	LHG1158

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LHG F1161

Chain	Residue
F	LHG1158

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ F1163

Chain	Residue
F	GLU50
F	GLY53
F	GLN54

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG F1164

Chain	Residue
F	LHG1159
F	LHG1166
G	MET1
G	MET2
G	LEU17

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG F1166

Chain	Residue
F	LHG1164
H	MET1
H	MET2
H	LEU17
I	LHG1159

site_id	EC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE UMQ F1167

Chain	Residue
C	LYS123
C	LYS124
C	GLU126
F	GLN54
F	PRO125
F	GLU126
F	THR129

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LHG G1158

Chain	Residue
F	PHE101
F	PHE105
G	LEU17
G	THR21
G	HOH2036
H	LYS32
H	LHG1159

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ G1160

Chain	Residue
G	GLU50
G	GLY53
G	HOH2018

site_id	EC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LHG H1158

Chain	Residue
G	PHE101
G	PHE105
H	LEU17
H	THR21
H	HOH2028
H	HOH2043
I	LYS32

site_id	EC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LHG H1159

Chain	Residue
G	LHG1158

site_id	EC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UMQ H1160

Chain	Residue
H	GLY53
H	GLN54

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UMQ H1161

Chain	Residue
H	GLU50
H	GLY53
H	HOH2044

site_id	EC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LHG I1158

Chain	Residue
H	PHE101
H	PHE105
I	LEU17
I	THR21
I	LEU104
I	PHE105
I	HOH2055
J	LYS32

site_id	FC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LHG I1159

Chain	Residue
F	LHG1166
I	MET1
I	MET2
I	LEU17
I	LHG1165

site_id	FC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE UMQ I1163

Chain	Residue
I	GLN54

site_id	FC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UMQ I1164

Chain	Residue
I	GLU50
I	PHE52
I	GLY53
I	HOH2056
I	HOH2057

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LHG I1165

Chain	Residue
A	LHG1159
I	LHG1159
J	MET2
J	LEU17

site_id	FC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LHG J1158

Chain	Residue
A	LYS32
A	LHG1158
A	LHG1159
A	LHG1160
I	PHE101
I	PHE105
J	LEU17
J	THR21
J	LEU104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	800
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)