2BKV
Structure and kinetics of a monomeric glucosamine-6-phosphate deaminase: missing link of the NagB superfamily
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004342 | molecular_function | glucosamine-6-phosphate deaminase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006043 | biological_process | glucosamine catabolic process |
| A | 0006044 | biological_process | N-acetylglucosamine metabolic process |
| A | 0006046 | biological_process | N-acetylglucosamine catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0004342 | molecular_function | glucosamine-6-phosphate deaminase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006043 | biological_process | glucosamine catabolic process |
| B | 0006044 | biological_process | N-acetylglucosamine metabolic process |
| B | 0006046 | biological_process | N-acetylglucosamine catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PGA A1242 |
| Chain | Residue |
| A | GLY37 |
| A | HOH2140 |
| A | HOH2177 |
| A | HOH2178 |
| A | GLY38 |
| A | THR39 |
| A | ILE133 |
| A | HIS138 |
| A | LYS202 |
| A | HOH2024 |
| A | HOH2110 |
| A | HOH2116 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PGA B1243 |
| Chain | Residue |
| B | GLY37 |
| B | GLY38 |
| B | THR39 |
| B | GLY132 |
| B | ILE133 |
| B | HIS138 |
| B | ARG167 |
| B | LYS202 |
| B | HOH2034 |
| B | HOH2140 |
| B | HOH2196 |
| B | HOH2197 |
| B | HOH2198 |
| B | HOH2199 |
Functional Information from PROSITE/UniProt
| site_id | PS01161 |
| Number of Residues | 19 |
| Details | GLC_GALNAC_ISOMERASE Glucosamine/galactosamine-6-phosphate isomerases signature. VdslGdTdIqLlGIGrNGH |
| Chain | Residue | Details |
| A | VAL120-HIS138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; for enolization step","evidences":[{"source":"HAMAP-Rule","id":"MF_01241","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For ring-opening step","evidences":[{"source":"HAMAP-Rule","id":"MF_01241","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; for ring-opening step","evidences":[{"source":"HAMAP-Rule","id":"MF_01241","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15755726","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BKX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cd5 |
| Chain | Residue | Details |
| A | ASN136 | |
| A | HIS138 | |
| A | GLU143 | |
| A | ASP67 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1cd5 |
| Chain | Residue | Details |
| B | ASN136 | |
| B | HIS138 | |
| B | GLU143 | |
| B | ASP67 |
