2BKQ
NEDD8 protease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000338 | biological_process | protein deneddylation |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0019784 | molecular_function | deNEDDylase activity |
| A | 0043687 | biological_process | post-translational protein modification |
| B | 0000338 | biological_process | protein deneddylation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0016579 | biological_process | protein deubiquitination |
| B | 0019784 | molecular_function | deNEDDylase activity |
| B | 0043687 | biological_process | post-translational protein modification |
| C | 0000338 | biological_process | protein deneddylation |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0016579 | biological_process | protein deubiquitination |
| C | 0019784 | molecular_function | deNEDDylase activity |
| C | 0043687 | biological_process | post-translational protein modification |
| D | 0000338 | biological_process | protein deneddylation |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0016579 | biological_process | protein deubiquitination |
| D | 0019784 | molecular_function | deNEDDylase activity |
| D | 0043687 | biological_process | post-translational protein modification |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | HIS102 | |
| A | ASP119 | |
| B | HIS102 | |
| B | ASP119 | |
| C | HIS102 | |
| C | ASP119 | |
| D | HIS102 | |
| D | ASP119 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | CYS163 | |
| B | CYS163 | |
| C | CYS163 | |
| D | CYS163 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
| C | MET1 | |
| D | MET1 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 2bkr |
| Chain | Residue | Details |
| A | TRP103 | |
| A | HIS102 | |
| A | ASP119 | |
| A | TRP26 | |
| A | CYS163 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 2bkr |
| Chain | Residue | Details |
| B | TRP103 | |
| B | HIS102 | |
| B | ASP119 | |
| B | TRP26 | |
| B | CYS163 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 2bkr |
| Chain | Residue | Details |
| C | TRP103 | |
| C | HIS102 | |
| C | ASP119 | |
| C | TRP26 | |
| C | CYS163 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 2bkr |
| Chain | Residue | Details |
| D | TRP103 | |
| D | HIS102 | |
| D | ASP119 | |
| D | TRP26 | |
| D | CYS163 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 820 |
| Chain | Residue | Details |
| A | TRP26 | electrostatic stabiliser |
| A | HIS102 | proton acceptor, proton donor |
| A | TRP103 | electrostatic stabiliser |
| A | ASP119 | electrostatic stabiliser |
| A | CYS163 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 820 |
| Chain | Residue | Details |
| B | TRP26 | electrostatic stabiliser |
| B | HIS102 | proton acceptor, proton donor |
| B | TRP103 | electrostatic stabiliser |
| B | ASP119 | electrostatic stabiliser |
| B | CYS163 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 820 |
| Chain | Residue | Details |
| C | TRP26 | electrostatic stabiliser |
| C | HIS102 | proton acceptor, proton donor |
| C | TRP103 | electrostatic stabiliser |
| C | ASP119 | electrostatic stabiliser |
| C | CYS163 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 820 |
| Chain | Residue | Details |
| D | TRP26 | electrostatic stabiliser |
| D | HIS102 | proton acceptor, proton donor |
| D | TRP103 | electrostatic stabiliser |
| D | ASP119 | electrostatic stabiliser |
| D | CYS163 | nucleofuge, nucleophile, proton acceptor, proton donor |
