2BKA
CC3(TIP30)Crystal Structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006915 | biological_process | apoptotic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030154 | biological_process | cell differentiation |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043068 | biological_process | positive regulation of programmed cell death |
| A | 0045765 | biological_process | regulation of angiogenesis |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046777 | biological_process | protein autophosphorylation |
| A | 0051170 | biological_process | import into nucleus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 904 |
| Chain | Residue |
| A | ARG96 |
| A | GLY100 |
| A | ALA101 |
| A | HOH2170 |
| A | HOH2334 |
| A | HOH2335 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 905 |
| Chain | Residue |
| A | LYS186 |
| A | HOH2263 |
| A | HOH2336 |
| A | HOH2337 |
| A | ARG96 |
| A | TRP182 |
| A | ARG185 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP A 506 |
| Chain | Residue |
| A | GLY25 |
| A | SER27 |
| A | GLY28 |
| A | GLU29 |
| A | THR30 |
| A | ARG52 |
| A | ARG53 |
| A | CYS91 |
| A | LEU92 |
| A | GLY93 |
| A | VAL107 |
| A | LEU130 |
| A | SER131 |
| A | TYR143 |
| A | LYS147 |
| A | PRO167 |
| A | GLY168 |
| A | LEU170 |
| A | ARG178 |
| A | PRO179 |
| A | GLY180 |
| A | HOH2179 |
| A | HOH2312 |
| A | HOH2313 |
| A | HOH2314 |
| A | HOH2315 |
| A | HOH2316 |
| A | HOH2317 |
| A | HOH2318 |
| A | HOH2319 |
| A | HOH2320 |
| A | HOH2321 |
| A | HOH2322 |
| A | HOH2323 |
| A | HOH2324 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PE8 A 901 |
| Chain | Residue |
| A | GLN175 |
| A | GLU181 |
| A | LEU183 |
| A | PHE187 |
| A | PHE188 |
| A | TRP195 |
| A | ALA196 |
| A | SER200 |
| A | HOH2325 |
| A | HOH2326 |
| A | HOH2327 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 902 |
| Chain | Residue |
| A | PHE72 |
| A | GLU73 |
| A | ARG106 |
| A | TYR111 |
| A | LYS114 |
| A | HOH2141 |
| A | HOH2329 |
| A | HOH2331 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 903 |
| Chain | Residue |
| A | LYS220 |
| A | GLN221 |
| A | MET222 |
| A | HOH2332 |
| A | HOH2333 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000303|PubMed:15728189 |
| Chain | Residue | Details |
| A | TYR143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000303|PubMed:15728189 |
| Chain | Residue | Details |
| A | LYS147 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15728189 |
| Chain | Residue | Details |
| A | LYS19 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000303|PubMed:15728189 |
| Chain | Residue | Details |
| A | SER131 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | ALA2 |
