2BJK
Crystal Analysis of 1-Pyrroline-5-Carboxylate Dehydrogenase from Thermus with bound NAD and citrate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003842 | molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0010133 | biological_process | proline catabolic process to glutamate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003842 | molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0010133 | biological_process | proline catabolic process to glutamate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FLC A1518 |
| Chain | Residue |
| A | GLU137 |
| A | NAD1517 |
| A | HOH2310 |
| A | HOH2312 |
| A | HOH2642 |
| A | HOH2652 |
| A | HOH2693 |
| A | HOH2695 |
| A | ASN184 |
| A | PHE185 |
| A | LYS321 |
| A | CYS322 |
| A | SER323 |
| A | GLY477 |
| A | ALA478 |
| A | PHE485 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A1523 |
| Chain | Residue |
| A | HIS465 |
| B | LYS510 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FLC B1518 |
| Chain | Residue |
| B | GLU137 |
| B | ASN184 |
| B | PHE185 |
| B | LYS321 |
| B | CYS322 |
| B | SER323 |
| B | GLY477 |
| B | ALA478 |
| B | PHE485 |
| B | NAD1517 |
| B | HOH2286 |
| B | HOH2602 |
| B | HOH2613 |
| B | HOH2650 |
| B | HOH2651 |
| B | HOH2652 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B1524 |
| Chain | Residue |
| A | LYS510 |
| B | HIS465 |
| site_id | AC5 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE NAD A1517 |
| Chain | Residue |
| A | ILE180 |
| A | ALA181 |
| A | PRO182 |
| A | TRP183 |
| A | ASN184 |
| A | ILE189 |
| A | LYS207 |
| A | ALA209 |
| A | GLU210 |
| A | GLY240 |
| A | GLU241 |
| A | GLY244 |
| A | ALA245 |
| A | PHE258 |
| A | THR259 |
| A | GLY260 |
| A | SER261 |
| A | VAL264 |
| A | GLU288 |
| A | THR289 |
| A | GLY290 |
| A | CYS322 |
| A | GLU417 |
| A | PHE419 |
| A | PHE485 |
| A | FLC1518 |
| A | HOH2373 |
| A | HOH2681 |
| A | HOH2682 |
| A | HOH2683 |
| A | HOH2684 |
| A | HOH2685 |
| A | HOH2686 |
| A | HOH2687 |
| A | HOH2688 |
| A | HOH2689 |
| A | HOH2690 |
| A | HOH2691 |
| A | HOH2692 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MRD A1519 |
| Chain | Residue |
| A | GLN279 |
| A | HOH2696 |
| A | HOH2697 |
| site_id | AC7 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAD B1517 |
| Chain | Residue |
| B | GLU417 |
| B | PHE419 |
| B | PHE485 |
| B | FLC1518 |
| B | HOH2353 |
| B | HOH2641 |
| B | HOH2642 |
| B | HOH2643 |
| B | HOH2644 |
| B | HOH2645 |
| B | HOH2646 |
| B | HOH2647 |
| B | HOH2648 |
| B | HOH2649 |
| B | ILE180 |
| B | ALA181 |
| B | PRO182 |
| B | TRP183 |
| B | ASN184 |
| B | ILE189 |
| B | LYS207 |
| B | ALA209 |
| B | GLU210 |
| B | GLY240 |
| B | GLY244 |
| B | ALA245 |
| B | PHE258 |
| B | THR259 |
| B | GLY260 |
| B | SER261 |
| B | VAL264 |
| B | GLU288 |
| B | THR289 |
| B | GLY290 |
| B | CYS322 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MRD B1519 |
| Chain | Residue |
| B | TYR171 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD B1521 |
| Chain | Residue |
| B | LEU275 |
| B | GLN279 |
| B | HOH2658 |
| B | HOH2659 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MRD B1523 |
| Chain | Residue |
| A | LEU27 |
| A | ARG28 |
| A | TYR122 |
| A | GLU355 |
| A | GLU356 |
| B | GLU355 |
| B | GLU356 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MPD A1520 |
| Chain | Residue |
| A | PHE6 |
| A | TYR144 |
| A | ARG147 |
| A | ALA148 |
| A | HOH2323 |
| A | HOH2698 |
| A | HOH2699 |
| A | HOH2700 |
| B | GLU158 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD A1521 |
| Chain | Residue |
| A | VAL312 |
| A | HOH2297 |
| A | HOH2468 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD A1522 |
| Chain | Residue |
| A | ARG36 |
| A | TYR38 |
| A | GLU221 |
| A | HOH2132 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MPD B1520 |
| Chain | Residue |
| A | GLU158 |
| B | PHE6 |
| B | TYR144 |
| B | ARG147 |
| B | ALA148 |
| B | HOH2298 |
| B | HOH2655 |
| B | HOH2656 |
| B | HOH2657 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B1522 |
| Chain | Residue |
| B | ARG36 |
| B | TRP46 |
| B | GLU221 |
| B | HOH2127 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YgFQGQKCSAAS |
| Chain | Residue | Details |
| A | TYR315-SER326 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. VETGGKDA |
| Chain | Residue | Details |
| A | VAL287-ALA294 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS322 | |
| A | ASN184 | |
| A | GLU288 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS322 | |
| B | ASN184 | |
| B | GLU288 |
