2BID
HUMAN PRO-APOPTOTIC PROTEIN BID
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001836 | biological_process | release of cytochrome c from mitochondria |
| A | 0005123 | molecular_function | death receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008625 | biological_process | extrinsic apoptotic signaling pathway via death domain receptors |
| A | 0008637 | biological_process | apoptotic mitochondrial changes |
| A | 0016020 | cellular_component | membrane |
| A | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042770 | biological_process | signal transduction in response to DNA damage |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0051402 | biological_process | neuron apoptotic process |
| A | 0065003 | biological_process | protein-containing complex assembly |
| A | 0090150 | biological_process | establishment of protein localization to membrane |
| A | 0090200 | biological_process | positive regulation of release of cytochrome c from mitochondria |
| A | 0097284 | biological_process | hepatocyte apoptotic process |
| A | 0097435 | biological_process | supramolecular fiber organization |
| A | 1902531 | biological_process | regulation of intracellular signal transduction |
| A | 2001233 | biological_process | regulation of apoptotic signaling pathway |
| A | 2001238 | biological_process | positive regulation of extrinsic apoptotic signaling pathway |
| A | 2001244 | biological_process | positive regulation of intrinsic apoptotic signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS01259 |
| Number of Residues | 15 |
| Details | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. IarhLAqVGDSMDRS |
| Chain | Residue | Details |
| A | ILE88-SER102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Motif: {"description":"BH3","evidences":[{"source":"UniProtKB","id":"P70444","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by CASP6","evidences":[{"source":"PubMed","id":"32029622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage;by CASP6","evidences":[{"source":"PubMed","id":"32029622","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage","evidences":[{"source":"UniProtKB","id":"P70444","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
