2BID

HUMAN PRO-APOPTOTIC PROTEIN BID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0005123	molecular_function	death receptor binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0006626	biological_process	protein targeting to mitochondrion
A	0006915	biological_process	apoptotic process
A	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
A	0008637	biological_process	apoptotic mitochondrial changes
A	0010918	biological_process	positive regulation of mitochondrial membrane potential
A	0016020	cellular_component	membrane
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031966	cellular_component	mitochondrial membrane
A	0033554	biological_process	cellular response to stress
A	0035556	biological_process	intracellular signal transduction
A	0042129	biological_process	regulation of T cell proliferation
A	0042770	biological_process	signal transduction in response to DNA damage
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0050678	biological_process	regulation of epithelial cell proliferation
A	0051402	biological_process	neuron apoptotic process
A	0065003	biological_process	protein-containing complex assembly
A	0090150	biological_process	establishment of protein localization to membrane
A	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0097284	biological_process	hepatocyte apoptotic process
A	0097345	biological_process	mitochondrial outer membrane permeabilization
A	0097435	biological_process	supramolecular fiber organization
A	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
A	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A	1902531	biological_process	regulation of intracellular signal transduction
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
A	2000271	biological_process	positive regulation of fibroblast apoptotic process
A	2001233	biological_process	regulation of apoptotic signaling pathway
A	2001235	biological_process	positive regulation of apoptotic signaling pathway
A	2001238	biological_process	positive regulation of extrinsic apoptotic signaling pathway
A	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. IarhLAqVGDSMDRS

Chain	Residue	Details
A	ILE88-SER102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Motif: {"description":"BH3","evidences":[{"source":"UniProtKB","id":"P70444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Cleavage; by CASP6","evidences":[{"source":"PubMed","id":"32029622","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage;by CASP6","evidences":[{"source":"PubMed","id":"32029622","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage","evidences":[{"source":"UniProtKB","id":"P70444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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